Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women

Vesentini, Giovana; Barbosa, Angélica Mércia Pascon; Damasceno, Débora Cristina; Marini, Gabriela; Pículo, Fernanda; Matheus, Selma Maria Michelin; Hallur, Raghavendra Lakshmana Shetty; Nunes, Sthefanie K.; Catinelli, B. B.; Magalhães, Cláudia Garcia; Costa, Roberto; Abbade, Joélcio Francisco; Corrente, José Eduardo; Calderon, Iracema de Mattos Paranhos; Rudge, Marilza Vieira Cunha

doi:10.1371/journal.pone.0231096

Cited by 15 publications

(17 citation statements)

References 63 publications

(82 reference statements)

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“…Overall, PFM functions measured by 3D‐TPUS are impaired in GDM women compared to non‐GDM women. The volume and distribution of different forms of collagen, or even the elevated collagen type I/III ratio found not only in diabetic pregnant rats, 13 but also in GDM women, 7 may have an impact on the regular biomechanical characteristics of PFM and RAM 8 …”

Section: Discussionmentioning

confidence: 99%

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Pelvic floor muscle dysfunction at 3D transperineal ultrasound in maternal exposure to gestational diabetes mellitus: A prospective cohort study during pregnancy

Pinheiro

Filho

Prudêncio

et al. 2022

Neurourology and Urodynamics

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Aim: This study aimed to assess, for the first time, the dynamic morphometry of pelvic floor muscles (PFM) using three-dimensional transperineal ultrasound (3D-TPUS) and its progression at two-time points of gestation between women with and without gestational diabetes mellitus (GDM), and whether the PFM dysfunction is connected to GDM. Methods:The study comprised 83 consecutive pregnant women with (n = 38) and without (n = 45) GDM screened at 24-30 and 38-40 weeks of gestation. 3D-TPUS and a mobility test were used to quantify PFM dynamic morphometry during maximum contraction and the Valsalva maneuver. Results: When compared to the control group, GDM women had no significant variations in all levator hiatal dimensions at 24-30 weeks of gestation. Meanwhile, women with GDM experienced an increase in levator hiatal area (LHa) (p < 0.000) during PFM contraction and enlargement in LHa (p < 0.001) during Valsalva maneuver (p = 0.010) at 38-40 weeks of gestation.

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Section: Discussionmentioning

confidence: 99%

“…Women with GDM have an increased risk of urinary incontinence (UI) within the first decade after delivery when compared to non‐GDM women 2–4 . Furthermore, GDM is linked to a muscle injury that weakens the pelvic floor muscle (PFM) and rectus abdominis muscles (RAM) during pregnancy 5–8 …”

Section: Introductionmentioning

confidence: 99%

Pelvic floor muscle dysfunction at 3D transperineal ultrasound in maternal exposure to gestational diabetes mellitus: A prospective cohort study during pregnancy

Pinheiro

Filho

Prudêncio

et al. 2022

Neurourology and Urodynamics

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“…В різніх роботах досліджували вплив вагітності та ГЦД на здатність інсуліну стимулювати транспорт глюкози у скелетні м'язові волокна людини in vitro. Свіжоізольовані скелетні м'язові волокна прямого м'язу живота були отримані у жінок із ожирінням та ГЦД підчас кесаревого розтину та порівняні з м'язовими волокнами вагітних із ожирінням із нормальною толерантністю до глюкози і відповідним ІМТ, віком та етнічною приналежностю [36]. В якості групи контролю отримали зразки прямого м'язу живота від невагітних пацієнток з ожирінням.…”

Section: механізми зменшення транспорту глюкози у скелетні м'язи у здорових вагітних та при гцдunclassified

“…В якості групи контролю отримали зразки прямого м'язу живота від невагітних пацієнток з ожирінням. Було безпосередньо продемонстровано на волокнах скелетних м'язів, що вагітність була пов'язана зі 40% зменшенням стимульованого інсуліном транспорту глюкози, і це порушення дії інсуліну було більш вираженим у пацієнток із ГЦД порівняно з вагітними із ожирінням без порушень вуглеводного обміну [36]. Зменшення транспорту глюкози відбувається за відсутності будь-яких помітних змін загальної кількості GLUT4 у скелетних м'язах у вагітних або у пацієнток з ГЦД [37].…”

Section: механізми зменшення транспорту глюкози у скелетні м'язи у здорових вагітних та при гцдunclassified

Molecular mechanisms of insulin resistance in normal pregnancy and gestational diabetes

Zhuravlyova¹,

Sokolnikova²,

Rogachova³

2021

Shidnoevr. z. vnutr. simejnoi med.

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The purpose of this review article is to analyze current information on the molecular mechanisms of gestational diabetes and the prospects for their use in the further development of new effective treatments for this common pathology. Decreased ability of insulin to bind to its receptor, decreased IRS-1 expression and GLUT-4 translocation, and increased levels of p85α-PI-3 kinase subunits are involved in the development of insulin resistance during pregnancy. In gestational diabetes, there are not only more significant changes of the above mentioned indicators, but also increased levels of pro-inflammatory factors: TNF-α, IL-6, leptin and decreased insulin-sensitizing factors: adiponectin and PPAR-γ. Therapeutic measures aimed at normalizing the secretion of cytokines and adipokines reduce the risk of gestational diabetes mellitus and its complications and require further development

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“…IBM's "Smart Hotel" project pursues humanized brilliant experience service. It proposes four robust solutions, including systematic monitoring and management, electronic keys, network unsubscription, and desktop cloud [10].…”

Section: Introductionmentioning

confidence: 99%

Design and Management of Control System for Rural Tourism Network Information Based on MVC Model

Dong

2021

Mobile Information Systems

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Tourism has developed into an industry with a powerful momentum of development in the world today. With the development of information technology, information has become a powerful driving force to promote the prosperity and development of the tourism industry and the entire society. The introduction of the tourism information system can significantly improve the service level, operation level, and management level of the tourism industry, thereby accelerating tourism development. The research of this article is to help villages establish a set of MVC-based rural tourism information service systems that can promote the development of rural tourism. First of all, this article conducts demand research on tourists, rural scenic spots, and ancient villages to discover the problems in rural tourism development. Secondly, this paper combines the problems existing in constructing the various subsystems of the rural tourism information system, combined with the fuzzy comprehensive evaluation method. In this paper, we propose the rural tourism system architecture based on MVC. The system architecture consists of the user layer, service layer, business layer, and data layer. It describes the system’s implementation process from two aspects: the system’s interface design and its deployment model. Finally, the network topology structure of the rural tourism information service system based on MVC is drawn. Finally, the system’s deployment is implemented according to the network topology structure.

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Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women

Abstract: ¶ Membership of the Termite Genome Working Group is listed in the Acknowledgments.

Cited by 15 publications

References 63 publications

Pelvic floor muscle dysfunction at 3D transperineal ultrasound in maternal exposure to gestational diabetes mellitus: A prospective cohort study during pregnancy

Pelvic floor muscle dysfunction at 3D transperineal ultrasound in maternal exposure to gestational diabetes mellitus: A prospective cohort study during pregnancy

Molecular mechanisms of insulin resistance in normal pregnancy and gestational diabetes

Design and Management of Control System for Rural Tourism Network Information Based on MVC Model

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