Alterations in the Reactive Oxygen Species in Peripheral Blood of Chronic Myeloid Leukaemia Patients from Northern India

Abstract

Introduction: There is a significant difference in the Reactive Oxygen Species (ROS) levels of Chronic Myeloid Leukaemia (CML) patients before and during treatment with Tyrosine Kinase Inhibitors (TKIs). This is because high ROS levels support oncogenic phenotype of CML by inducing proliferation pathway and accumulation of further genetic mutations. Often the measurement is done on WBC or serum for ascertaining one type of ROS species, but measurement of global ROS in fresh whole blood will give more accurate estimation of ROS. Aim:To measure global ROS in peripheral blood of CML patients.

The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia

“…In recent years, it has become increasingly apparent that ROS are elevated in cancer cells [10] (Figure 3). In myeloid neoplasms there is evidence for increased ROS in myelodysplastic syndrome [65], chronic myelomonocytic leukaemia [66], chronic myeloid leukaemia [67] , and myeloproliferative neoplasms [68]. This is no different in AML, where the roles for ROS in driving leukaemogenesis are ever expanding.…”