Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status

Presti, Rachel; Handley, Scott A.; Droit, Lindsay; Ghannoum, Mahmoud A.; Jacobson, Mark A.; Shiboski, Caroline H.; Webster‐Cyriaque, Jennifer; Brown, Todd J.; Yin, Michael T.; Overton, Edgar Turner

doi:10.1097/qad.0000000000001811

Cited by 47 publications

(72 citation statements)

References 42 publications

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“…As with previous studies that analyzed the bacteriome of other specimens from HIV-infected individuals, such as saliva, bronchoalveolar lavage (BAL) and stool [ 6 , 7 , 13 , 27 ], the HIV-infected individuals had altered palatine tonsil bacteriome. Changes of alpha diversity in HIV infection are variable, increased in some studies, decreased or not changed in others [ 20 , 27 – 31 ].…”

Section: Discussionmentioning

confidence: 52%

“…The microbiome (the collective genomes of microbial flora) of HIV-infected individuals is gradually being elucidated [ 6 , 7 ], as human microbiome research progresses [ 8 ]. The role of microbial flora in pathogenesis of HIV infection has been the subject of much research in recent years [ 7 , 9 – 13 ]. Dysbiosis during HIV infection such as increased abundance of pathogenic Prevotella in the oral cavity and decreased abundance of Lactobacillus in the gut has been reported, and the loss of a normal microbial flora may influence HIV transmission, prevention, progression and prognosis [ 12 , 14 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

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The palatine tonsil bacteriome, but not the mycobiome, is altered in HIV infection

et al. 2018

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BackgroundMicrobial flora in several organs of HIV-infected individuals have been characterized; however, the palatine tonsil bacteriome and mycobiome and their relationship with each other remain unclear. Determining the palatine tonsil microbiome may provide a better understanding of the pathogenesis of oral and systemic complications in HIV-infected individuals. We conducted a cross-sectional study to characterize the palatine tonsil microbiome in HIV-infected individuals.ResultsPalatine tonsillar swabs were collected from 46 HIV-infected and 20 HIV-uninfected individuals. The bacteriome and mycobiome were analyzed by amplicon sequencing using Illumina MiSeq. The palatine tonsil bacteriome of the HIV-infected individuals differed from that of HIV-uninfected individuals in terms of the decreased relative abundances of the commensal genera Neisseria and Haemophilus. At the species level, the relative abundances and presence of Capnocytophaga ochracea, Neisseria cinerea, and Selenomonas noxia were higher in the HIV-infected group than those in the HIV-uninfected group. In contrast, fungal diversity and composition did not differ significantly between the two groups. Microbial intercorrelation analysis revealed that Candida and Neisseria were negatively correlated with each other in the HIV-infected group. HIV immune status did not influence the palatine tonsil microbiome in the HIV-infected individuals.ConclusionsHIV-infected individuals exhibit dysbiotic changes in their palatine tonsil bacteriome, independent of immunological status.Electronic supplementary materialThe online version of this article (10.1186/s12866-018-1274-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

The palatine tonsil bacteriome, but not the mycobiome, is altered in HIV infection

et al. 2018

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“…In addition, Starr et al () speculated that in adolescents whose HIV‐1 infection is controlled by HAART or other therapies, the oral microbiota would be similar to that of non‐HIV‐1‐infected, and the microorganisms that cause oral disease would also be similar. Even though, Presti et al (), in a cohort study with HIV‐1‐infected adults, did not find changes in the salivary microbiome after 24 weeks of HAART, with Bacteroidetes, Firmicutes and Proteobacteria remaining the more abundant phyla.…”

Section: Discussionmentioning

confidence: 95%

“…A number of authors have studied the oral microbiota of HIV-1infected individuals using gene amplicon sequencing (Beck et al, 2015;Dang et al, 2012;Goldberg et al, 2015;Kistler, Arirachakaran, Poovorawan, Dahlen, & Wade, 2015;Li et al, 2014;Noguera-Julian et al, 2017;Presti et al, 2018;Starr et al, 2018); however, only two papers have been published regarding the oral microbiome of HIV-1-infected children (Goldberg et al, 2015;Starr et al, 2018).…”

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confidence: 99%

Oral bacteriome of HIV‐1‐infected children from Rio de Janeiro, Brazil: Next‐generation DNA sequencing analysis

Gonçalves

Ferreira

Heng

et al. 2019

J Clinic Periodontology

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Background and Aim This study compared the oral bacteriome between HIV‐1‐infected and non‐HIV‐1‐infected Brazilian children/teenagers. Methods Whole saliva, biofilm from the dorsal surface of the tongue and biofilm from supragingival and subgingival sites were collected from 27 HIV‐1‐infected and 30 non‐HIV‐1‐infected individuals. Bacterial genomic DNA was extracted and 16S rRNA genes were sequenced using next‐generation sequencing technology (Ion Torrent). Results In the supragingival biofilm, the phylum Firmicutes and genus Streptococcus sp. were more frequent in HIV‐1‐infected (95% and 78%, respectively) than in non‐HIV‐1‐infected individuals (40% and 24%, respectively). In the subgingival biofilm of HIV‐infected participants, the relative abundance of the Veillonella sp. and Prevotella sp. genera were higher than in non‐HIV‐1‐infected participants. On the tongue, the genera with greater relative abundance in HIV‐1‐infected individuals were Neisseria sp. (21%). In saliva, the difference of the genus Prevotella sp. between non‐HIV‐1‐infected and HIV‐1‐infected individuals was 15% and 7%, respectively. The Chao index revealed an increase in the richness of both sub‐ and supragingival biofilms in the HIV‐1‐infected samples compared with non‐HIV‐1‐infected samples. Conclusion HIV‐1‐infected children/teenagers have a higher frequency of the phyla Firmicutes and genus Streptococcus, and their oral microbiome shows more complexity than that of non‐HIV‐1‐infected children/teenagers.

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“…For examples, there were increases of Porphyromonas sp. and Corynebacterium order in HIV-infected individuals compared to HIV-negative individuals [41,42].…”

Section: Discussionmentioning

confidence: 99%

Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA

et al. 2020

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Infection by Kaposi's sarcoma-associated herpesvirus (KSHV) is necessary for the development of Kaposi's sarcoma (KS), which most often develops in HIV-infected individuals. KS frequently has oral manifestations and KSHV DNA can be detected in oral cells. Numerous types of cancer are associated with the alteration of microbiome including bacteria and virus. We hypothesize that oral bacterial microbiota affects or is affected by oral KS and the presence of oral cell-associated KSHV DNA. In this study, oral and blood specimens were collected from a cohort of HIV/KSHV-coinfected individuals all previously diagnosed with KS, and were classified as having oral KS with any oral cell-associated KSHV DNA status (O-KS, n = 9), no oral KS but with oral cell-associated KSHV DNA (O-KSHV, n = 10), or with neither oral KS nor oral cell-associated KSHV DNA (No KSHV, n = 10). We sequenced the hypervariable V1-V2 region of the 16S rRNA gene present in oral cell-associated DNA by next generation sequencing. The diversity, richness, relative abundance of operational taxonomic units (OTUs) and taxonomic composition of oral microbiota were analyzed and compared across the 3 studied groups. We found impoverishment of oral microbial diversity and enrichment of specific microbiota in O-KS individuals compared to O-KSHV or No KSHV individuals. These results suggest that HIV/KSHV coinfection and oral microbiota might impact one another and influence the development of oral KS.

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Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status

Abstract: Shifts in the oral microbiome after ART initiation are complex, and may play an important role in immune function and inflammatory disease.

Cited by 47 publications

References 42 publications

The palatine tonsil bacteriome, but not the mycobiome, is altered in HIV infection

The palatine tonsil bacteriome, but not the mycobiome, is altered in HIV infection

Oral bacteriome of HIV‐1‐infected children from Rio de Janeiro, Brazil: Next‐generation DNA sequencing analysis

Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA

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