Alterations in the non-specific cortical afference during hyperventilation

Sherwin, Ira

doi:10.1016/0013-4694(67)90019-3

Cited by 17 publications

(16 citation statements)

References 12 publications

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“…Because cortical rhythmic activity arises from an interplay between thalamic relay cells with cells in the reticular nuclei and cortico-cortical reverberant loops [30, 31], the VEP changes we recorded after deep-breathing-induced HV could plausibly depend on thalamic neuronal hyperpolarization. This neural mechanism accords perfectly with early evidence that lesions involving the anterior pole of the thalamus (nucleus centralis lateralis) abolish the cortical response to HV [32, 33]. Another major brain nervous structure involved in HV-induced EEG changes is the reticular formation.…”

Section: Discussionsupporting

confidence: 87%

Changes in visual-evoked potential habituation induced by hyperventilation in migraine

et al. 2010

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Hyperventilation is often associated with stress, an established trigger factor for migraine. Between attacks, migraine is associated with a deficit in habituation to visual-evoked potentials (VEP) that worsens just before the attack. Hyperventilation slows electroencephalographic (EEG) activity and decreases the functional response in the occipital cortex during visual stimulation. The neural mechanisms underlying deficient-evoked potential habituation in migraineurs remain unclear. To find out whether hyperventilation alters VEP habituation, we recorded VEPs before and after experimentally induced hyperventilation lasting 3 min in 18 healthy subjects and 18 migraine patients between attacks. We measured VEP P100 amplitudes in six sequential blocks of 100 sweeps and habituation as the change in amplitude over the six blocks. In healthy subjects, hyperventilation decreased VEP amplitude in block 1 and abolished the normal VEP habituation. In migraine patients, hyperventilation further decreased the already low block 1 amplitude and worsened the interictal habituation deficit. Hyperventilation worsens the habituation deficit in migraineurs possibly by increasing dysrhythmia in the brainstem-thalamo-cortical network.

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Section: Discussionsupporting

confidence: 87%

Changes in visual-evoked potential habituation induced by hyperventilation in migraine

et al. 2010

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“…Experiments performed by Ira Sherwin in the 1960s represent some of the few attempts to do so. Sherwin posed two key questions in his experiments: (1) what brain structures are recruited by hyperventilation to increase the occurrence of SWDs (Sherwin, 1965, 1967), and (2) do these structures possess a specific, element that is responsive to respiratory-induced changes in pH?…”

Section: A Basic Modulation Of the Thalamusmentioning

confidence: 99%

“…In 1967, Sherwin presented a study that demonstrated a critical role for the NSTPS in modulating cortical excitability (Sherwin, 1967). Sherwin specifically examined the contribution of the central lateral (CL) nucleus, a member of the NSTPS, to hyperventilation-induced changes in cortical excitability and HIHARS.…”

Section: A Basic Modulation Of the Thalamusmentioning

confidence: 99%

Out of thin air: Hyperventilation-triggered seizures

Salvati

Beenhakker

2019

Brain Research

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“…The study of regional cerebral blood flow (rCBF) by the subtraction technique of brain images with single-photon emission computed tomography directly demonstrates a close correlation between the hyperventilation-induced EEG and rCBF changes [36]. Bonvallet and Dell [37] suggested that hypocapnia produces depression of the ascending reticular activating system and causes synchronous slowing, while clinical [38] and experimental [39] studies implicated increased activity in the non-specific thalamocortical projecting systems during hyperventilation as the cause of slowing.…”

Section: Discussionmentioning

confidence: 99%

EEG Alterations in Subjects at High Familial Risk for Alzheimer’s Disease

2003

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Twenty first-order relatives of patients with early-onset Alzheimer’s disease (AD; mean age 43.7 ± 1.3 years), 20 patients with early-onset AD (mean age 65.7 ± 0.9 years) and age-matched normal controls for the relatives and the patients underwent quantitative EEG (qEEG) examinations. In AD patients, delta and theta relative power values were increased and alpha relative power was decreased compared with normal controls. The AD patients’ relatives had normal resting EEG parameters. Under hyperventilation in the AD relatives, synchronous high-voltage delta and theta activity and sharp waves were revealed, theta and delta relative powers were increased and alpha relative power was decreased compared with the resting EEG in the same persons. Moreover, under hyperventilation, the theta and delta relative powers in the EEG of the relatives were higher, and the alpha relative power was lower compared with the EEG of normal controls under the same conditions. It is suggested that the excitotoxic processes and oxidative stress underlie the EEG alterations in the AD patients’ relatives and that these alterations may be related to the further AD development.

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Alterations in the non-specific cortical afference during hyperventilation

Cited by 17 publications

References 12 publications

Changes in visual-evoked potential habituation induced by hyperventilation in migraine

Changes in visual-evoked potential habituation induced by hyperventilation in migraine

Out of thin air: Hyperventilation-triggered seizures

EEG Alterations in Subjects at High Familial Risk for Alzheimer’s Disease

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