Alterations in the Mitochondrial Physiology of Biomphalaria glabrata (Mollusca: Gastropoda) After Experimental Infection by Angiostrongylus cantonensis (Nematoda: Metastrongylidae)

Tunholi-Alves, Vinícius Menezes; Tunholi, Victor Menezes; Amaral, Ludimila Santos; Garcia, Juberlan Silva; Lima, Mariana Gomes; DaMatta, Renato Augusto; Pinheiro, Jairo

doi:10.2478/s11686-019-00039-7

Cited by 7 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mitochondrial toxicity of Cd has been shown in clams (Ji et al, 2019), mitochondrial dysfunctions in mussel hemocytes are induced after an exposure to titanium particles (Wang et al, 2019) and infection of B. glabrata with nematodes induces suppression of mitochondrial oxidative metabolism (Tunholi-Alves et al, 2019). In this sense, we believe that investigating the consequences of environmental information on cellular metabolism is of great interest to first investigate the link between the environment and DNA methylation.…”

Section: 3-dna Methylation Is Responsive To the Environment In Mollmentioning

confidence: 99%

Epigenetic inheritance and intergenerational effects in mollusks

Fallet

Luquet

David

et al. 2020

Gene

View full text Add to dashboard Cite

List of abbreviations 5mC5-methylcytosine, a cytosine that has been modified by the addition of a methyl group on its 5th carbon ADP Adenosine diphosphate AFLP Amplified fragment length polymorphism BLAST Basic Local Alignment Search Tool BS-Seq Bisulfite sequencing BS-PCR-Seq PCr amplification after bisulfite sequencing followed by sequencing Cd Cadium meDIP-seq Methylated DNA Immunoprecipitation sequencing MiRNAs Micro RNAs MSAP Methylation-sensitive amplified polymorphism MS-PCR Methylation-specific PCR pCO2 partial pressure of C02 PCR Polymerase chain reaction PTMs Post-Translational Modifications pH potential of Hydrogen qPCR quantitative Polymerase chain reaction RT-qPCR quantitative reverse transcription PCR RNA Ribonucleic acid RRBS Reduced representation bisulfite sequencing SAM S-adenosyl methionine SDS-PAGE Sodium Dodecil Sulfate PolyAcrylamide Gel Electrophoresis UV-HPLC Ultraviolet High performance liquid chromatography Abstract Recent insights in evolutionary biology have shed light on epigenetic variation that interacts with genetic variation to convey heritable information. An important characteristic of epigenetic changes is that they can be produced in response to environmental cues and passed on to later generations, potentially facilitating later genetic adaptation. While our understanding of epigenetic mechanisms in vertebrates is rapidly growing, our knowledge about invertebrates remains lower, or is restricted to model organisms. Mollusks in particular, are a large group of invertebrates, with several species important for ecosystem function, human economy and health. In this review, we attempt to summarize the literature on epigenetic and 4 intergenerational studies in mollusk species, with potential importance for adaptive evolution. Our review highlights that two molecular bearers of epigenetic information, DNA methylation and histone modifications, are key features for development in mollusk species, and both are sensitive to environmental conditions to which developing individuals are exposed. Further, although studies are still scarce, various environmental factors (e.g. predator cues, chemicals, parasites) can induce intergenerational effects on the phenotype (life-history traits, morphology, behaviour) of several mollusk taxa. More work is needed to better understand whether environmentally-induced changes in DNA methylation and histone modifications have phenotypic impacts, whether they can be inherited through generations and their role in intergenerational effects on phenotype. Such work may bring insight into the potential role of epigenetic in adaptation and evolution in mollusks.

show abstract

Section: 3-dna Methylation Is Responsive To the Environment In Mollmentioning

confidence: 99%