Alterations in the intestinal microbiota of patients with severe and active Graves’ orbitopathy: a cross-sectional study

Shi, Tingting; Zhong, Xin; Hua, Lin; Zhao, Ru-Xuan; Yang, Yilin; Wang, H.; Zhang, S.; Liu, W.; Xie, Ruming

doi:10.1007/s40618-019-1010-9

Cited by 47 publications

(45 citation statements)

References 32 publications

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“…A similar cross-sectional study compared 33 patients with severe active GO, who were mainly hyperthyroid and receiving ATDs, with 32 healthy controls. Their finding of significantly reduced diversity in patients agreed with that of Ishaq et al [34], but Shi et al [35] observed significantly increased Bacteroidetes and decreased Firmicutes in their GO patients' gut microbiota. Whether the relative abundance of Bacteroidetes and Firmicutes phyla reported reflects real differences between the gut microbiota composition of GD and GO patients or the impact of ATD therapy remains to be elucidated.…”

Section: Studies On the Role For The Microbiome In Gd And Gosupporting

confidence: 72%

Microbiome and Graves’ Orbitopathy

Masetti¹,

Ludgate²

2020

Eur Thyroid J

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Background: Studies from animal models of autoimmunity have highlighted the potential importance of microorganisms and their metabolic products in shaping the immune system. Summary: This review provides an introduction to the current state-of-the-art in microbiome research both from the perspective of “what is known” and of methodologies for its investigation. It then summarises the evidence for a role for the microbiome in the pathogenesis of Graves’ disease and Graves’ orbitopathy with reference to animal models and studies in human cohorts, from both published and ongoing sources. Key Message: Microbiome research is in its infancy but has already provided novel insights into disease pathogenesis across the spectrum from cancer to mental health and autoimmunity.

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Section: Studies On the Role For The Microbiome In Gd And Gosupporting

confidence: 72%

Microbiome and Graves’ Orbitopathy

Masetti¹,

Ludgate²

2020

Eur Thyroid J

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“…For instance, community diversity was significantly reduced in patients with GO. At the phylum level, the proportion of Bacteroidetes was notably increased, while at the genus and species levels, significant differences were observed [9]. e present study highlighted the role of microbiota in occurrence of GO.…”

Section: Introductionsupporting

confidence: 47%

“…In the present study, we applied a metabolic-network-driven analysis to explore the relationships between gut microbiota and GO-related traits and identified a number of novel associations between gut microbiota and serum TRAb. In our previous study, linear discriminant analysis effect size (LEfSe) analysis and random forest analysis showed that Prevotellaceae was one discriminative feature, which could distinguish GO patients from controls obviously [9]. In the present study, Prevotellaceae was identified as an important family of bacteria associated with TRAb.…”

Section: Discussionmentioning

confidence: 62%

“…e exclusion criteria for the GO patients were patients' age <18 or >65 years, history of chronic diarrhea or constipation, history of gastrointestinal surgery, therapy of probiotics or antibiotics over the previous 4 weeks, use of hormonal medication (<3 months), severe disease (acute infections, diabetes, stroke, renal or hepatic dysfunction, cancer, or autoimmune diseases), pure vegetarian, etc. [9]. e characteristics of the study subjects are summarized in Table 1. is study was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (Registration No.…”

Section: Study Subjectsmentioning

confidence: 99%

“…e abundance information on the OTUs was normalized using a standard sequence number, corresponding to each sample with the least number of sequences as previously described [9].…”

Section: Stool Sample Microbiota Sequencing Otu Cluster Andmentioning

confidence: 99%

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The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy

Shi

Hua

Wang

et al. 2019

International Journal of Endocrinology

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Background and Objective. A previous study reported alterations in the intestinal microbiota in patients with Graves’ orbitopathy (GO). Thyrotropin receptor autoantibody (TRAb) stimulates orbital and periorbital tissues and plays a pivotal role in the development of GO. However, the association between gut microbiota and TRAb in GO patients has still remained elusive. In this study, we explored the relationships between gut microbiota and GO-related traits, in which we applied a metabolic-network-driven analysis to identify GO trait-related modules and extracted significant operational taxonomic units (OTUs). Methods. In the present study, we profiled gut microbiota using 16S rRNA gene sequencing in 31 GO patients. We performed metabolic-network-driven analysis to investigate the association between gut microbiota and GO-related traits (e.g., TRAb, TGAb, and TPOAb) in the combination of microbial effects. Results. Applying microbiome network analysis of cooccurrence patterns and analysis of topological properties, we found that s_Prevotella_copri and f_Prevotellaceae showed a significant correlation with TRAb. In particular, we applied the latent class model to explore the association between gut microbiota and GO-related traits in the combination of microbial effects. It was revealed that the subjects involved in the latent class model with the higher abundance of s_Prevotella_copri and g_Bacteroides had a higher TRAb level. Conclusions. Our results revealed the potential relationships between gut microbiota and GO-related traits in the combination of microbial effects. This study may provide a new insight into the interaction between the intestinal microbiota and TRAb-associated immune responses in GO patients.

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