Alterations in the Function of Cerebral Dopaminergic and Serotonergic Systems Following Electroacupuncture and Moxibustion Applications: Possible Correlates with Their Antistress and Psychosomatic Actions

Yano, Tadashi; Kato, Baku; Fukuda, Fumihiko; Satoh, Hisashi; Yoshimoto, Kanji; Ozaki, Akihiro; Kuriyama, Kinya

doi:10.1023/b:nere.0000010457.00855.8c

Cited by 35 publications

(22 citation statements)

References 17 publications

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“…Recently, neurochemical studies on the relationship between the contents of dopamine (DA), serotonin (5-HT) and their metabolites in the central nervous system (CNS) and application of acupuncture were reported (Kato 2000;Yano et al 2004). However, the effects of acupuncture on the in vivo release of DA and 5-HT in the CNS are still unclear.…”

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confidence: 99%

Acupuncture Stimulates the Release of Serotonin, but Not Dopamine, in the Rat Nucleus Accumbens

Yoshimoto

Fukuda

Hori

et al. 2006

Tohoku J. Exp. Med.

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Acupuncture has been introduced as one of the available therapies widely used in alternative medicine, but it has not achieved widespread acceptance with scientific evidence. Furthermore there are still many unanswered questions about the basic mechanisms of acupuncture. To investigate the neuropharmacological mechanisms of oriental acupuncture, we studied the acupuncture-induced changes of in vivo monoamine release in the rat brain. A microdialysis guide cannula was implanted into the nucleus accumbens (ACC), which plays an important role in the brain reward system. Acupuncture treatment at the unilateral or bilateral Shenshu (bladder urinary channel 23) acupoints, located on the both sides of the spinous processes on the lower back, was carried out for 60 min in freely moving rats, and the dopamine (DA) and serotonin (5-HT) contents of the microdialysates in the ACC were measured simultaneously. In rats subjected to acupuncture at bilateral Shenshu acupoints, increases of 5-HT release in the ACC were observed at 20 min of acupuncture treatment and continued until 40 min after acupuncture was ended. Acupuncture at a unilateral Shenshu acupoint increased the release of 5-HT at 20 min compared with that in the sham-control group. Five-HT release returned to the baseline level at 120 min. The effects of acupuncture at bilateral Shenshu acupoints on the release of 5-HT in the ACC were greater than that of unilateral acupuncture treatment. In contrast, DA release in the ACC was not changed following acupuncture treatment. Effective acupuncture increased and prolonged the activity of serotonergic neurons in the reward system pathway of the brain. This suggests that oriental acupuncture therapy may be effective for the treatment of emotional disorders, drug abuse and alcoholism.

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confidence: 99%

Acupuncture Stimulates the Release of Serotonin, but Not Dopamine, in the Rat Nucleus Accumbens

Yoshimoto

Fukuda

Hori

et al. 2006

Tohoku J. Exp. Med.

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“…However, unfortunately, we can not fully understand how moxibustion worked. We can just speculate the mechanism might be related with its promoting effect on cortical cerebral blood flow (Uchida et al, 2003), and its stimulating effect on central nervous system (Yano et al, 2004). …”

Section: Discussionmentioning

confidence: 99%

The effectiveness of moxibustion on dysphagia after stroke; A Case Series

Cho¹,

Kim²,

Jung³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study was aimed to evaluate the effectiveness of moxibustion on dysphagia after stroke. We conducted his study in the Department of Cardiovascular and Neurologic Diseases (Stroke Center), Hospital of Oriental Medicine, Kyung Hee Medical Center, from May 1, 2005 to August 1, 2006. After recruiting dysphagia patients after stroke, we applied the Direct Moxibustion (1.2 × 1.4 cm) to the Chon-Jung acupoint 5 times, and assessed its effect on swallowing reflex by Swallowing Provocation Test (SPT) before and 30 min after treatment. Effectiveness of the swallowing reflex was assessed by the Latency Time of Swallowing Reflex (LTSR) which was checked from test starting to the onset of swallowing reflex. Thirty four subjects with dysphagia were treated with moxibustion. The mean of the latency time in swallowing reflex was shortened from 2.2 ± 0.9 to 1.5 ± 0.5 seconds after moxibustion, which had statistical significance (P < 0.001). We suggest that moxibustion at Chon-Jung could be useful for dysphagia after stroke. Further study with a randomized controlled trial compared to placebo is needed to confirm this suggestion.

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“…Acupuncture is useful in the treatment of anxiety and insomnia because of its effect on the dopaminergic and serotonergic neurons and the opiate system as well as for its pain relief feature. These effects tend to interact with each other (Spence et al, 2004;Yano et al, 2004;Nedstrand et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Acupuncture as a Complementary Treatment for Cancer Patients Receiving Chemotherapy

Taş

Uncu²,

Şendur³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Medical treatment for eliminating the side effects of cancer therapy may not always be efficacious. Acupuncture is one of the most widely accepted alternative and complementary therapies in use today. In this study, we investigated the efficacy of acupuncture in patients experiencing cancer treatment side effects, including nausea, vomiting, pain, poor sleep quality and anxiety. Materials and Methods: A total of 45 inpatients who underwent chemotherapy between February and April 2013 in the Oncology Department of Numune Hospital were included in our study. Acupuncture was administered to the patients one day prior to chemotherapy, on the day of chemotherapy and one day after chemotherapy. The patients were evaluated on nausea, vomiting, pain, sleep quality and anxiety before the chemotherapy and on the 4 th day of chemotherapy. Results: Of the 45 patients included in the study, 18 (40%) were female and 27 (60%) were male. A total of 25 (55.6%) had an elementary school education; 32 patients (71%) had stage 4 cancer and were treated with palliative chemotherapy (the patient characteristics are shown in Table 1). Statistically significant decreases (p<0.001) in pain, nausea, vomiting, insomnia and anxiety scores were observed after the acupuncture treatment compared to baseline. There were no differences in the age, gender, education level, stage or metastasis levels between the patient groups whose symptoms improved or were unchanged. Conclusions: Our study showed that acupuncture has positive effects in cancer treatment patients who experience nausea, vomiting, pain, poor sleep quality and anxiety as side effects of chemotherapy. Chemotherapy-related side effects in cancer patients could be decreased by the concurrent use of acupuncture.

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Alterations in the Function of Cerebral Dopaminergic and Serotonergic Systems Following Electroacupuncture and Moxibustion Applications: Possible Correlates with Their Antistress and Psychosomatic Actions

Cited by 35 publications

References 17 publications

Acupuncture Stimulates the Release of Serotonin, but Not Dopamine, in the Rat Nucleus Accumbens

Acupuncture Stimulates the Release of Serotonin, but Not Dopamine, in the Rat Nucleus Accumbens

The effectiveness of moxibustion on dysphagia after stroke; A Case Series

Acupuncture as a Complementary Treatment for Cancer Patients Receiving Chemotherapy

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