Alterations in the Expression of p53, KLF4, and p21 in Neuroendocrine Lung Tumors

Gómez, José Manuel Naranjo; Bernal, José Fernando Val; Arranz, Pilar; Fernández, Servando Lazuén; Román, José Javier Gómez

doi:10.5858/arpa.2013-0119-oa

Cited by 15 publications

(14 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, we found KLF4 upregulated CRYAB expression and bound the promoter of CRYAB. CRYAB, a human small heat-shock protein, has been found involved in a variety of processes including cytoskeletal assembly, remodeling and apoptosis inhibition [ 14 ]. CRYAB has been reported as a prognostic marker in several cancers, such as breast, renal, thyroid, nasopharyngeal, hepatocellular and lung cancers [ 7 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression

Zhang

Xia

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, is an essential regulator in many cellular processes, including differentiation, proliferation, inflammation, pluripotency, and apoptosis. Along with these roles in normal cells and tissues, KLF4 has been reported as a tumor suppressor or an oncogene in many cancers. However, the role of KLF4 in osteosarcoma is largely unknown. Here we found the expression of KLF4 was significantly increased in human osteosarcoma tissues compared with the normal tissues. Elevated KLF4 promoted human osteosarcoma cell proliferation and metastasis. Subsequently, mechanistic studies revealed KLF4 specifically bound the promoter of CRYAB and upregulated CRYAB expression in human osteosarcoma cells. Moreover, we found that KLF4 enhanced osteosarcoma cell proliferation and migration via upregulating CRYAB. Therefore, our studies suggested KLF4 may be a potential target for human osteosarcoma therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression

Zhang

Xia

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Finally, KLF4 plays a key role in cancer progression and development. Mounting evidence shows that KLF4 expression and activity is altered in a large number of human cancers, including gastric [ 10 ], colorectal [ 11 ], esophageal [ 12 ], prostate [ 13 ], lung [ 14 ], bladder [ 15 ], and B-lymphocyte cancers [ 16 ]. KLF4 expression is significantly reduced in all of these tumors, consistent with its roles in cell cycle checkpoints and growth arrest.…”

Section: Introductionmentioning

confidence: 99%

The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells

Liu

et al. 2015

Oncotarget

View full text Add to dashboard Cite

Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor that regulates many essential processes, including development and cell differentiation, proliferation, and apoptosis. Along with these roles in normal cells and tissues, KLF4 has important tumor suppressive and oncogenic functions in some malignancies. However, the roles of KLF4 in oral squamous cell carcinoma remain unclear. This study investigated the epigenetic alterations and possible roles of KLF4 in oral cancer carcinogenesis. Notably, KLF4 expression was significantly decreased in human oral cancer tissues compared with healthy controls, and KLF4 promoter hypermethylation contributed to the suppression of KLF4 expression. KLF4 expression was associated with tumor grade. Its expression was much lower in poorly differentiated oral cancers than in well-differentiated cancer cells. KLF4 exerted its antitumor activity in vitro and/or in vivo by inhibiting cell proliferation, cell cycle progression, cell colony formation and by inducing apoptosis. In addition, KLF4 over-expression promoted oral cancer cell migration and invasion in vitro. Knockdown of KLF4 promoted oral cancer cells growth and colony formation, and simultaneously inhibited cell migration and invasion. Mechanistic studies revealed that MMP-9 might contribute to KLF4-mediated cell migration and invasion. These results provide evidence that KLF4 might play Janus-faced roles in oral cancer carcinogenesis, acting both as a tumor suppressor and as an oncogene.

show abstract

“…It is involved in epidermal barrier function (68), cell proliferation, differentiation and apoptosis (69) and stem cell renewal (70). The activity and expression of KLF4 are often associated with mutation in various cancers (71)(72)(73)(74). Li et al (75), identified that KLF4 was downregulated in OSCC, and its downregulation correlated with cancer differentiation i.e., the poorer the cancer differentiation, the lower the expression of KLF.…”

Section: Saliva-detectable Hypermethylationmentioning

confidence: 99%

Epigenetics of oral and oropharyngeal cancers (Review)

et al. 2018

View full text Add to dashboard Cite

Oral and oropharyngeal cancers represent the two most common malignancies of the head and neck region. The major risk factors for these cancers include alcohol consumption, tobacco use (via smoking or chewing) and high-risk human papillomavirus infection. The transition from normal epithelium to premalignant tissue and finally carcinoma is in part caused by a summation of genetic and epigenetic modifications. Epigenetic refers to modifications in the way the genome is expressed in cells. The most common examples of epigenetic control of gene expression are DNA methylation, histone modification and regulation by small non-coding RNAs. The aim of the current paper was to review the recent studies on the main epigenetic changes that have been suggested to serve a role in the carcinogenesis process and progression of oral and oropharyngeal cancers. Furthermore, it is discussed how the epigenetic changes may be used as potential predictive biomarkers and how recent findings in the field may impact the personalized cancer therapy approach for these tumors.

show abstract

Alterations in the Expression of p53, KLF4, and p21 in Neuroendocrine Lung Tumors

Cited by 15 publications

References 35 publications

Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression

Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression

The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells

Epigenetics of oral and oropharyngeal cancers (Review)

Contact Info

Product

Resources

About