Alterations in the Choroidal Sublayers in Relationship to Severity and Progression of Diabetic Retinopathy

Kung, Erica W.T.; Chan, Victor T.T.; Tang, Zhangjun; Yang, Dawei; Sun, Zihan; Wang, Yumeng; Chan, Chi-Chao; Kwan, Mei Po; Shi, Junnan; Cheung, Carol Y.

doi:10.1016/j.xops.2022.100130

Cited by 10 publications

(2 citation statements)

References 93 publications

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“…OCTA is commonly used in conjunction with DR biomarker identification because it can provide a layered view of the retinal and choroidal vasculature in living tissue (73, 74). In OCTA pictures, biomarkers of DR were observed as the expansion of the macula without perfusion, a reduction in vessel density, and vascular structural alterations in the fundus (75)(76)(77). The development of wide-angle OCTA has increased the sensitivity of spotting non-perfusion regions and neovascular arteries in the retina (78).…”

Section: Biomarkers and Octamentioning

confidence: 99%

Global trends and performances in diabetic retinopathy studies: A bibliometric analysis

Xiao

Tang

Zhang

et al. 2023

Front. Public Health

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ObjectiveThe objective of this study is to conduct a comprehensive bibliometric analysis to identify and evaluate global trends in diabetic retinopathy (DR) research and visualize the focus and frontiers of this field.MethodsDiabetic retinopathy-related publications from the establishment of the Web of Science (WOS) through 1 November 2022 were retrieved for qualitative and quantitative analyses. This study analyzed annual publication counts, prolific countries, institutions, journals, and the top 10 most cited literature. The findings were presented through descriptive statistics. VOSviewer 1.6.17 was used to exhibit keywords with high frequency and national cooperation networks, while CiteSpace 5.5.R2 displayed the timeline and burst keywords for each term.ResultsA total of 10,709 references were analyzed, and the number of publications continuously increased over the investigated period. America had the highest h-index and citation frequency, contributing to the most influence. China was the most prolific country, producing 3,168 articles. The University of London had the highest productivity. The top three productive journals were from America, and Investigative Ophthalmology Visual Science had the highest number of publications. The article from Gulshan et al. (2016; co-citation counts, 2,897) served as the representative and symbolic reference. The main research topics in this area were incidence, pathogenesis, treatment, and artificial intelligence (AI). Deep learning, models, biomarkers, and optical coherence tomography angiography (OCTA) of DR were frontier hotspots.ConclusionBibliometric analysis in this study provided valuable insights into global trends in DR research frontiers. Four key study directions and three research frontiers were extracted from the extensive DR-related literature. As the incidence of DR continues to increase, DR prevention and treatment have become a pressing public health concern and a significant area of research interest. In addition, the development of AI technologies and telemedicine has emerged as promising research frontiers for balancing the number of doctors and patients.

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Section: Biomarkers and Octamentioning

confidence: 99%

Global trends and performances in diabetic retinopathy studies: A bibliometric analysis

Xiao

Tang

Zhang

et al. 2023

Front. Public Health

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“…Among OCT parameters, a larger choroidal area and choroidal thickness in Haller’s layer at baseline were associated with a higher risk of DR progression over 2 years of follow-up. The predictive value of these choroidal metrics was not influenced by other factors, such as disease duration, HbA1c, body mass index, insulin use, and mean arterial blood pressure [ 102 ]. The involvement of the outer choroidal layer was also observed in diabetic patients before starting systemic hypoglycemic medication [ 103 ].…”

Section: Clinical and Prognostic Significance Of Diabetic Choroidopathymentioning

confidence: 99%

The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy

Scuderi

Fragiotta

Pippo

et al. 2023

IJMS

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Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller’s layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy.

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Diabetic retinopathy and choroidopathy: Pathophysiology, imaging findings, and treatment updates

Silpa-archa,

Tadarati,

Chotcomwongse

et al. 2024

Retinal and Choroidal Vascular Diseases of the Eye

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Alterations in the Choroidal Sublayers in Relationship to Severity and Progression of Diabetic Retinopathy

Cited by 10 publications

References 93 publications

Global trends and performances in diabetic retinopathy studies: A bibliometric analysis

Global trends and performances in diabetic retinopathy studies: A bibliometric analysis

The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy

Diabetic retinopathy and choroidopathy: Pathophysiology, imaging findings, and treatment updates

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