Alterations in the choroid in hypercholesterolemic rabbits: Reversibility after normalization of cholesterol levels

Salazar, Juan J.; Ramírez, Ana I.; Hoz, Rosa de; Rojas, Blanca; Ruiz, Emilio Muñoz; Tejerina, Teresa; Triviño, Alberto; Ramı́rez, José M.

doi:10.1016/j.exer.2006.10.012

Cited by 43 publications

(69 citation statements)

References 40 publications

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“…Outro estudo experimental observou que gotículas de colesterol na supracoróide comprimem as camadas vasculares e provocam hipertrofia das células endoteliais e musculares lisas vasculares (8) . Neste estudo foi verificado que a espessura supracoroidea está aumentada em coelhos hipercolesterolêmicos devido à abundância de fibras colágenas.…”

Section: Discussionunclassified

“…No presente relato foi possível evidenciar o significativo aumento da espessura da coróide e da esclera nos coelhos com a dieta hipercolesterolêmica, corroborando a teoria vascular. É importante frisar que os estudos destinados à avaliação das alterações coriorretinianas em olhos de coelhos realizados até a presente data, caracterizaram-se pela administração de dieta colesterol 0,5% durante o período mínimo de 6 meses (6)(7)(8) . No presente relato foi possível obter alterações em 6 semanas de dieta hipercolesterolêmica.…”

Section: Discussionunclassified

“…A região posterior também demonstrou aumento de espessura no G1, porém sem significância estatísti-ca. Estes resultados coincidem com outro relato (8) .…”

Section: Discussionunclassified

“…Recente estudo demonstrou que níveis altos de HDL preveniriam a DMRI tardia enquanto alto nível de colesterol total proporcionaria risco maior para DMRI tardia e atrofia geográfica (3) . Em modelo animal tem sido demonstrado que a dieta rica em colesterol ocasiona alterações coriorretinianas similares às ocorridas na DMRI humana (4)(5)(6)(7)(8) . O objetivo deste trabalho é mostrar experimentalmente, através de exames histológicos e histomorfomé-tricos, que as alterações degenerativas da esclera e coróide ocorrem precocemente ao administrar dieta hipercolesterolê-mica a coelhos.…”

Section: Resumo Introduçãounclassified

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Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Torres¹,

Maia²,

Noronha³

et al. 2009

Arq. Bras. Oftalmol.

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Section: Discussionunclassified

“…A região posterior também demonstrou aumento de espessura no G1, porém sem significância estatísti-ca. Estes resultados coincidem com outro relato (8) .…”

Section: Discussionunclassified

Section: Resumo Introduçãounclassified

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Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Torres¹,

Maia²,

Noronha³

et al. 2009

Arq. Bras. Oftalmol.

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“…It has been shown in animal models that arteriosclerotic changes occur in retina and choroid [22]. Recent studies related with microcirculation abnormality showed the thinning of SCFT in patients with retinitis pigmentosa [11][12][13] and chronic kidney disease [10] by using SD-OCT measurements.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Kanar¹,

Kanar²

2018

Eur J Exp Bio

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Objective: Although the pathophysiological mechanisms underlying coronary slow flow (CSF) phenomenon still remains uncertain, the microvascular dysfunction has been first implicated. The CSF phenomenon may not only affect the coronary arteries but it may also be a part of vascular problem that affect other arteries. The aim of the present study is to evaluate the relationship between CSF phenomenon and subfoveal choroidal thickness (SFCT) and to investigate the effect of short-term atorvastatin therapy on SFCT in patients with CSF. Methods:The study population consisted of 48 patients with CSF and 41 healthy control participants. Coronary flow patterns of the patients were determined by thrombolysis in myocardial infarction (TIMI) frame count method. Spectral-domain optical coherence tomography (SD-OCT) measurements of SFCT and lipid parameters were obtained before and after 2 weeks of daily single dose of 80 mg atorvastatin therapy. Results:We found that patients with CSF had thinner SFCT compared with control group. There was a significant negative correlation between mean TIMI frame count and baseline SFCT (r=-0.69, p=0.001). ROC curve analysis revealed that SFCT <259 m predicted CSF with a 85% sensitivity and 88% specificity. The SFCT significantly increased after the short-term atorvastatin therapy. Conclusion:There was a close negative correlation between CSF phenomenon and SFCT. Endothelial dysfunction (ED) and the resultant microvascular dysfunction might be operative on both coronary and ocular choriocapillary arteries in patients with CSF. Increase of SFCT after the short-term atorvastatin therapy might be an indicator of microvascular dysfunction improvement in patients with CSF.

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Cholesterol regulates polymodal sensory transduction in Müller glia

Lakk

Yarishkin

Baumann

et al. 2017

Glia

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Over- and underexposure to cholesterol activates glia in neurodegenerative brain and retinal diseases but the molecular targets of cholesterol in glial cells are not known. Here, we report that disruption of unesterified membrane cholesterol content modulates the transduction of chemical, mechanical and temperature stimuli in mouse Müller cells. Activation of TRPV4 (transient receptor potential vanilloid type 4), a nonselective polymodal cation channel was studied following the removal or supplementation of cholesterol using the methyl-beta cyclodextrin (MβCD) delivery vehicle. Cholesterol extraction disrupted lipid rafts and caveolae without affecting TRPV4 trafficking or membrane localization of the protein. However, MβCD suppressed agonist (GSK1016790A)- and temperature-evoked elevations in [Ca2+]i, and suppressed transcellular propagation of Ca2+ waves. Lowering the free membrane cholesterol content markedly prolonged the time-course of the glial swelling response, whereas MβCD:cholesterol supplementation enhanced agonist- and temperature-induced Ca2+ signals and shortened the swelling response. Taken together, these data show that membrane cholesterol modulates polymodal transduction of agonists, swelling and temperature stimuli in retinal radial glia and suggest that dyslipidemic retinas might be associated with abnormal glial transduction of ambient sensory inputs.

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Alterations in the choroid in hypercholesterolemic rabbits: Reversibility after normalization of cholesterol levels

Cited by 43 publications

References 40 publications

Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Cholesterol regulates polymodal sensory transduction in Müller glia

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