Alterations in symptoms and health‐related quality of life as kidney function deteriorates: A cross‐sectional study

Yapa, Harith Eranga; Purtell, Louise; Chambers, Shirley; Bonner, Ann

doi:10.1111/jocn.15738

Cited by 13 publications

(21 citation statements)

References 45 publications

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“…Indeed, chronic kidney disease has a high risk of comorbidity with several neuropsychiatric disorders, such as depression and anxiety disorders, since patients with chronic kidney disease suffer from distress due to continuous various restrictions and long-term medication [28]. Emotional disturbances, such as anxiety or depressive mood/perception can possibly impair and prolong the shared decision-making process, leading to blame being placed on the healthcare team [28,29]. It was previously established that the most important factors for patients when choosing a kidney replacement therapy is their own ability to express their personal values and beliefs based on independence and flexibility [22,30].…”

Section: Introductionmentioning

confidence: 99%

Impacts of Interaction of Mental Condition and Quality of Life between Donors and Recipients at Decision-Making of Preemptive and Post-Dialysis Living-Donor Kidney Transplantation

Hasegawa

Nishikawa

Tamura

et al. 2021

JPM

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Pre-emptive kidney transplantation (PEKT) is considered one of the most effective types of kidney replacement therapies to improve the quality of life (QOL) and physical prognosis of patients with end-stage renal disease (ESRD). In Japan, living-donor kidney transplantation is a common therapeutic option for patients undergoing dialyses (PDKT). Moreover, during shared decision-making in kidney replacement therapy, the medical staff of the multidisciplinary kidney team often provide educational consultation programmes according to the QOL and sociopsychological status of the ESRD patient. In Japan, the majority of kidney donations are provided by living family members. However, neither the psychosocial status of donors associated with the decision-making of kidney donations nor the interactions of the psychosocial status between donors and recipients have been clarified in the literature. In response to this gap, the present study determined the QOL, mood and anxiety status of donors and recipients at kidney transplantation decision-making between PEKT and PDKT. Deterioration of the recipient’s QOL associated with “role physical” shifted the decision-making to PEKT, whereas deterioration of QOL associated with “role emotional” and “social functioning” of the recipients shifted the decision-making to PDKT. Furthermore, increased tension/anxiety and depressive mood contributed to choosing PDKT, but increased confusion was dominantly observed in PEKT recipients. These direct impact factors for decision-making were secondarily regulated by the trait anxiety of the recipients. Unlike the recipients, the donors’ QOL associated with vitality contributed to choosing PDKT, whereas the physical and mental health of the donors shifted the decision-making to PEKT. Interestingly, we also detected the typical features of PEKT donors, who showed higher tolerability against the trait anxiety of reactive tension/anxiety than PDKT donors. These results suggest that choosing between either PEKT or PDKT is likely achieved through the proactive support of family members as candidate donors, rather than the recipients. Furthermore, PDKT is possibly facilitated by an enrichment of the life–work–family balance of the donors. Therefore, multidisciplinary kidney teams should be aware of the familial psychodynamics between patients with ESRD and their family members during the shared decision-making process by continuing the educational consultation programmes for the kidney-replacement-therapy decision-making process.

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Section: Introductionmentioning

confidence: 99%

Impacts of Interaction of Mental Condition and Quality of Life between Donors and Recipients at Decision-Making of Preemptive and Post-Dialysis Living-Donor Kidney Transplantation

Hasegawa

Nishikawa

Tamura

et al. 2021

JPM

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“…The vast majority of studies reported data collected in CKD G4–5 patients (30 studies), whereas far fewer studies reported data on GI symptomatology in the early stages of CKD (6 in G1–2 [ 9 , 32 , 33 , 34 , 35 , 36 ]; 10 in G3 [ 9 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]). Subgroup characteristics were described in Supplementary Materials, Results S1 .…”

Section: Resultsmentioning

confidence: 99%

“…They were conducted primarily in the WHO Western Pacific (9 studies [ 24 , 26 , 35 , 37 , 42 , 55 , 56 , 58 , 64 ]) and European (8 studies [ 23 , 28 , 30 , 31 , 38 , 44 , 53 , 62 , 65 ]) Regions. Data were collected using authors’ questionnaires/during anamnesis in the case of 8 studies, and using validated questionnaires: renal version of the Patient Outcome Scale—symptom module (POS-S Renal; 5 studies [ 24 , 27 , 31 , 35 , 64 ]); Integrated Palliative Care Outcome Scale (IPOS)-Renal (3 studies [ 26 , 37 , 39 ]); Dialysis Symptom Index (DSI) (3 studies [ 23 , 53 , 57 , 58 ]); Memorial Symptom Assessment Scale–Short Form (MSAS-SF; 2 studies [ 44 , 62 ]).…”

Section: Resultsmentioning

confidence: 99%

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Prevalence and Severity of Lower Gastrointestinal Symptoms amongst Non-Dialysis Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis

Ruszkowski

Majkutewicz

Heleniak

et al. 2022

JCM

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Chronic kidney disease (CKD) patients experience a wide range of symptoms that deteriorate their health-related quality of life (HRQoL). We aimed to estimate the prevalence and severity of lower gastrointestinal (GI) symptoms in non-dialysis CKD adult outpatients, and to summarize the relationships between these symptoms and HRQoL, laboratory test results, and clinical data. The protocol of the study was preregistered (PROSPERO CRD42021255122). We searched MEDLINE, Scopus, Web of Science, and grey literature sources from the databases’ inception up until 27 November 2021. Wide citation chasing was conducted. Single proportions (prevalence of functional constipation, self-reported constipation, diarrhea, abdominal bloating, fecal incontinence, and abdominal/rectal pain) were pooled using generalized linear mixed models. A total of 37 studies with 12,074 patients were included. We found that lower GI symptoms, especially self-reported abdominal bloating [CKD G1–2: 48.45% (95% CI: 43.5–53.4%; 2 studies); G3: 46.95% (95% CI: 45.0–48.9%; 2 studies), G4–5: 36.1% (95% CI: 25.4–48.5%; 8 studies)] and constipation [CKD G1–2: 31.8% (95% CI: 13.9–54.9%); G3: 29.8% (95% CI: 21.2–40.1%; 4 studies); G4–5: 38.8% (95% CI: 30.9–47.4%); 22 studies)], were common in non-dialysis CKD patients. The severity of the symptoms was limited. Self-reported constipation was most consistently associated with worse HRQoL, whereas hard stool consistency was associated with higher uremic toxins levels. To conclude, since lower GI symptoms are common in CKD, using symptom questionnaires that do not take them into account cannot provide full insight into the patient’s experience. Further studies are needed to cover identified knowledge gaps, including the exploration of the pathophysiology of GI symptoms in CKD with multi-omics data.

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“…HRQOL can predict disease-related factors and assess prognosis, thus guiding the treatment of specific populations. Poor HRQOL was a common problem in dialysis patients and contributed to low survival rates and high emotional stress ( Yapa et al, 2021 ). With this in mind, HRQOL is increasingly recognized as a key prognostic measure to evaluate the effectiveness of kidney disease treatment ( Lightfoot et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Exercise Self-Efficacy and Health-Related Quality of Life Among Dialysis Patients: A Cross-Sectional Study

et al. 2022

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BackgroundExercise self-efficacy is a vital determinant of an individual’s active participation in regular exercise, and exercise is a critical component of improving health-related quality of life (HRQOL) in dialysis patients. This study aimed to describe the relationship between exercise self-efficacy and HRQOL in dialysis patients.Materials and MethodsA cross-sectional study was conducted in Shanghai, China. Structured questionnaires distributed to the patients collected socio-demographic and disease-related information. Physical activity was assessed by a self-administered questionnaire, and the exercise self-efficacy scale (ESES) was used to measure exercise self-efficacy. HRQOL was evaluated by the kidney disease quality of life instrument-short form version 1.3 (KDQOL-SF™ v1.3). Data were analyzed using a univariate generalized linear model, Spearman correlation, and hierarchical multiple regression.ResultsA positive association was observed between exercise self-efficacy and HRQOL (r = 0.310, p < 0.001). Physical activity as a predictor variable explained 9.8% of the variance in overall HRQOL (p < 0.001). Exercise self-efficacy explained an additional 7.1% of the HRQOL variance. In total, 24.6% of the variation in the HRQOL was explained by the socio-demographic variables, disease-related factors, physical activity, and exercise self-efficacy.ConclusionOverall, only 16.9% of the change in HRQOL was explained by physical activity and exercise self-efficacy. Future research is still needed to further explore the factors influencing the HRQOL in dialysis patients. However, this finding suggests the need to consider the importance of HRQOL and physical activity as well as exercise self-efficacy when developing intervention programs.

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Alterations in symptoms and health‐related quality of life as kidney function deteriorates: A cross‐sectional study

Cited by 13 publications

References 45 publications

Impacts of Interaction of Mental Condition and Quality of Life between Donors and Recipients at Decision-Making of Preemptive and Post-Dialysis Living-Donor Kidney Transplantation

Impacts of Interaction of Mental Condition and Quality of Life between Donors and Recipients at Decision-Making of Preemptive and Post-Dialysis Living-Donor Kidney Transplantation

Prevalence and Severity of Lower Gastrointestinal Symptoms amongst Non-Dialysis Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis

Association Between Exercise Self-Efficacy and Health-Related Quality of Life Among Dialysis Patients: A Cross-Sectional Study

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