Alterations in sweet taste function in adults with diabetes mellitus: a systematic review and potential implications

Tan, Sze‐Yen; Hack, Caitlyn; Yu, Cindy H. J.; Rennick, Isabella; Ohanian, James; Dezan, Marina; Mott, Nicole M.; Manibo, Rebecca; Tucker, Robin M.

doi:10.1080/10408398.2021.2015282

Cited by 10 publications

(5 citation statements)

References 46 publications

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“…Recent research has highlighted the increasing association of DM with taste impairments [4]. Specifically, DM has been shown to negatively influence the perception of sweet, salty, and bitter tastes [5,6]. Electrogustometric thresholds, for instance, tend to increase notably in patients with diabetes [3,7].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the supportive cells surrounding TRCs may also be compromised, further impairing taste perception. The resultant taste disorders could potentially exacerbate the dietary challenges faced by individuals with DM, underscoring the necessity of understanding and addressing the histopathological alterations in taste buds that are induced by DM [6,13].…”

Section: Introductionmentioning

confidence: 99%

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4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm2, contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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“…49,50 Changes in dietary composition and diabetes status, have also been associated with alteration in sweet taste. 51 It should be highlighted that most studies investigating changes in sweet taste function post-RYGB recruited participants without diabetes, whereas we studied a unique cohort with prediabetes/diabetes.…”

Section: Discussionmentioning

confidence: 99%

Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single‐blind placebo‐controlled study

Behary

Alessmii

Miras

et al. 2023

Diabetes Obesity Metabolism

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Aims To investigate whether the elevation in postprandial concentrations of the gut hormones glucagon‐like peptide‐1 (GLP‐1), oxyntomodulin (OXM) and peptide YY (PYY) accounts for the beneficial changes in food preferences, sweet taste function and eating behaviour after Roux‐en‐Y gastric bypass (RYGB). Materials and methods This was a secondary analysis of a randomized single‐blind study in which we infused GLP‐1, OXM, PYY (GOP) or 0.9% saline subcutaneously for 4 weeks in 24 subjects with obesity and prediabetes/diabetes, to replicate their peak postprandial concentrations, as measured at 1 month in a matched RYGB cohort (http://clinicaltrials.gov NCT01945840). A 4‐day food diary and validated eating behaviour questionnaires were completed. Sweet taste detection was measured using the method of constant stimuli. Correct sucrose identification (corrected hit rates) was recorded, and sweet taste detection thresholds (EC50s: half maximum effective concencration values) were derived from concentration curves. The intensity and consummatory reward value of sweet taste were assessed using the generalized Labelled Magnitude Scale. Results Mean daily energy intake was reduced by 27% with GOP but no significant changes in food preferences were observed, whereas a reduction in fat and increase in protein intake were seen post‐RYGB. There was no change in corrected hit rates or detection thresholds for sucrose detection following GOP infusion. Additionally, GOP did not alter the intensity or consummatory reward value of sweet taste. A significant reduction in restraint eating, comparable to the RYGB group was observed with GOP. Conclusion The elevation in plasma GOP concentrations after RYGB is unlikely to mediate changes in food preferences and sweet taste function after surgery but may promote restraint eating.

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“…This was not too surprising as poorly controlled diabetes not only affects kidney function but also induces neuropathy. Our previous review demonstrated that individuals with diabetes, especially those for whom the condition is poorly controlled, also experienced taste impairment, potentially due to damage to the chorda tympani, greater petrosal, glossopharyngeal, and vagal nerves, which play important roles in human taste function [49]. The duration of CKD, but not the stage or the severity of CKD, was shown to influence taste function [28,41].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Salt Taste Function and Perception Impairments in Adults with Chronic Kidney Disease

Tan

Tuli

Thio

et al. 2022

IJERPH

Self Cite

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Individuals with chronic kidney disease (CKD) experience physiological changes that likely impair salt taste function and perception. Sodium restriction is a cornerstone of CKD management but dietary sodium plays an important role in food enjoyment and may interfere with compliance to this intervention. Therefore, confirming that taste deficits are present in CKD will improve our understanding of how taste deficits can affect intake, and inform dietary counselling in the future. A systematic review was conducted. Studies that included adults with CKD and healthy controls, and assessed salt taste sensitivity, perceived intensity, and/or hedonic ratings were included. Study quality was assessed using the Academy of Nutrition and Dietetics Evidence Analysis Library Quality Criteria Checklist: Primary Research. Of the 16 studies, the majority reported decreased salt taste sensitivity, but no consistent differences in intensity or hedonic ratings were observed. Higher recognition thresholds in CKD patients were associated with higher sodium intake, but results should be interpreted with caution as the measures used were subject to error in this population. In conclusion, salt taste sensitivity is decreased in CKD, but intensity and hedonic evaluations appear to be more robust. Given that hedonic assessments are better predictors of intake, and that salt taste preferences can be changed over time, dietary counselling for low-sodium intake is likely to be effective for this population.

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Alterations in sweet taste function in adults with diabetes mellitus: a systematic review and potential implications

Cited by 10 publications

References 46 publications

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single‐blind placebo‐controlled study

A Systematic Review of Salt Taste Function and Perception Impairments in Adults with Chronic Kidney Disease

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