Alterations in steroid hormone production by porcine ovarian granulosa cells caused by bisphenol A and bisphenol A dimethacrylate

Mlynarčíková, Alžbeta Bujňáková; Kolena, J; Ficková, M; Scsuková, Soňa

doi:10.1016/j.mce.2005.02.009

Cited by 92 publications

(59 citation statements)

References 28 publications

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“…For example, BPA (10 −8 -10 −5 M) stimulates basal and FSH-induced progesterone production while inhibiting FSH-stimulated E 2 secretion in pig granulosa cells in vitro [118]. The mechanism of action for BPA in granulosa cells has not, however, been reported.…”

Section: -Effects Of Estrogenic and Anti-androgenic Endocrine Disrupmentioning

confidence: 99%

Developmental exposure to environmental endocrine disruptors: Consequences within the ovary and on female reproductive function☆

Uzumcu

Zachow

2007

Reproductive Toxicology

114

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Female reproductive function depends upon the exquisite control of ovarian steroidogenesis that enables folliculogenesis, ovulation, and pregnancy. These mechanisms are set during fetal and/or neonatal development and undergo phases of differentiation throughout pre-and post-pubescent life. Ovarian development and function are collectively regulated by a host of endogenous growth factors, cytokines, gonadotropins, and steroid hormones as well as exogenous factors such as nutrients and environmental agents. Endocrine disruptors represent one class of environmental agent that can impact female fertility by altering ovarian development and function, purportedly through estrogenic, anti-estrogenic, and/or anti-androgenic effects. This review discusses ovarian development and function and how these processes are affected by some of the known estrogenic and anti-androgenic endocrine disruptors. Recent information suggests not only that exposure to endocrine disruptors during the developmental period causes reproductive abnormalities in adult life but also that these abnormalities are transgenerational. This latter finding adds another level of importance for identifying and understanding the mechanisms of action of these agents. 1-IntroductionThe primary function of an adult ovary is to produce the steroid and protein hormones needed to support (1) the development and maturation of ovarian follicles (i.e., folliculogenesis) including oocytes, (2) ovulation, and (3) the initiation and maintenance of pregnancy in mammals. In order for this to collectively occur, the secretion of ovarian hormones is tightly regulated by the neuroendocrine system and is locally controlled by many intraovarian feedback mechanisms (reviewed in [1]).Two major developmental events within the ovary are follicular assembly (i.e., the formation of primordial follicles) and the primordial-to-primary follicle transition (the "initial" recruitment) [1]. The initial phase of folliculogenesis is regulated by paracrine growth factors Correspondence: Dr. Mehmet Uzumcu, Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ Supported by NIH grant R21 ES013854-01A1 (MU) and funds from Robert Wood Johnson Medical School-UMDNJ (RZ).Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptReprod Toxicol. Author manuscript; available in PMC 2007 August 21. Published in final edited form as:Reprod Toxicol. 2007 ; 23(3): 337-352. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-...

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Section: -Effects Of Estrogenic and Anti-androgenic Endocrine Disrupmentioning

confidence: 99%

Developmental exposure to environmental endocrine disruptors: Consequences within the ovary and on female reproductive function☆

Uzumcu

Zachow

2007

Reproductive Toxicology

114

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“…In cultured porcine granulosa cells, all doses of BPA (0.1-10 mM) decreased progesterone production, while a low dose of 0.1 mM increased E 2 levels and high doses ranging from 1 to 100 mM BPA decreased E 2 production (Grasselli et al 2010). Another study with porcine granulosa cells showed that, depending on the dose given, BPA increased basal (1 mM) and FSHinduced (10 mM) progesterone production, while it inhibited (1-100 mM) FSH-induced E 2 production (Mlynarcíková et al 2005). Furthermore, BPA (100 mM) decreased progesterone production, decreased expansion of cumulus cells and inhibited oocyte maturation in porcine oocyte-cumulus complexes (Mlynarcíková et al 2009).…”

Section: Plasticizers: Bisphenol a And Phthalatesmentioning

confidence: 99%

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Craig¹,

Wang²,

Flaws³

2011

Reproduction

224

123

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Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere with processes regulated by endogenous hormones. One such process is female reproductive function. The major reproductive organ in the female is the ovary. Disruptions in ovarian processes by EDCs can lead to adverse outcomes such as anovulation, infertility, estrogen deficiency, and premature ovarian failure among others. This review summarizes the effects of EDCs on ovarian function by describing how they interfere with hormone signaling via two mechanisms: altering the availability of ovarian hormones, and altering binding and activity of the hormone at the receptor level. Among the chemicals covered are pesticides (e.g. dichlorodiphenyltrichloroethane and methoxychlor), plasticizers (e.g. bisphenol A and phthalates), dioxins, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons (e.g. benzo[a]pyrene).

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“…Further evidence of the effect of BPA on ovarian granulosa cells was provided by Mlynarcikova et al (2005), who demonstrated decreased FSH-induced oestradiol production by porcine ovarian granulosa cells after 72 h incubation with BPA in the range of 10 −8 -10 −4 M. More recently, in rat ovarian granulosa cells cultured in vitro with BPA, Zhou et al (2008) demonstrated a concentration-dependent inhibitory effect of BPA (10 −6 -10 −4 M) on oestradiol levels and the expression of P450arom mRNA. The decrease in oestradiol production was shown to be mediated, in part, by disruption of ovarian steroidogenic enzymes, specifically the mRNA expression of P450arom, a key enzyme in oestradiol synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro studies have confirmed the ability of BPA to disrupt meiotic spindle formation, centrosome dynamics and chromosome alignment and segregation (Can et al, 2005;Lenie et al, 2008). In addition to oocyte aneuploidy, in vitro studies using porcine and rat ovarian cells showed that exposure to low doses of BPA resulted in significant concentrationdependent inhibition of oestradiol production (Mlynarcikova et al, 2005;Zhou et al, 2008).…”

Section: Introductionmentioning

confidence: 89%

Urinary bisphenol a concentrations and ovarian response among women undergoing IVF

Mok-Lin

Ehrlich

Williams

et al. 2009

Fertility and Sterility

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Alterations in steroid hormone production by porcine ovarian granulosa cells caused by bisphenol A and bisphenol A dimethacrylate

Cited by 92 publications

References 28 publications

Developmental exposure to environmental endocrine disruptors: Consequences within the ovary and on female reproductive function☆

Developmental exposure to environmental endocrine disruptors: Consequences within the ovary and on female reproductive function☆

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Urinary bisphenol a concentrations and ovarian response among women undergoing IVF

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