Alterations in Skeletal Calcium and Phosphorus in Dysfunction of the Parathyroids1

Cohn, S. H.; Roginsky, Martin S.; Aloia, John F.; Ellis, Kenneth J.; Shukla, K.K.

doi:10.1210/jcem-36-4-750

Cited by 19 publications

(10 citation statements)

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“…Since we were not employing our own normal prediction formula, normality in an individual patient in our group was not so easy to detect. However, to provide a measure of comparison, we have observed in 12 early (< 1 year) postmenopausal women with no evidence of bone disease (mean age 47) in another study, mean measured/predicted ratios of 0.95 [8], 0.87 [2] (height), and 0.92 [9] (span). These values are thus similar to those for the hyperparathyroid patients.…”

Section: Discussionmentioning

confidence: 94%

“…Unfortunately, it is not possible to compare our results of initial assessments with the first report by Hosking et al [1] because the expression of their measurements was not in units of mass. In the second one, by Cohn et al [2], the calcium mass in a group of 8 patients with mild PHPT, all without radiological bone disease, was described. They found a mean measured/predicted normal ratio for the untreated patients of 89 _+ 7 (SD) %.…”

Section: Discussionmentioning

confidence: 99%

“…The first two reports [1][2] on total calcium in PHPT using neutron activation analysis include 18 patients. Unfortunately, it is not possible to compare our results of initial assessments with the first report by Hosking et al [1] because the expression of their measurements was not in units of mass.…”

Section: Discussionmentioning

confidence: 99%

“…As 99% of the total calcium mass is in bone, we have utilized whole body neutron activation analysis to measure the total body calcium in a group of such patients. A few studies [1][2][3] have reported certain changes in bone mass, but the long-term effect of the disease has not been assessed quantitatively.Send offprint requests to Dr. G. E Joplin at the above address. …”

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confidence: 99%

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Total body calcium mass in primary hyperparathyroidism and long-term changes

et al. 1984

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The total body calcium mass of patients with primary hyperparathyroidism was measured by whole-body neutron activation analysis. Among 14 untreated patients, the calcium mass was significantly subnormal in 2. Long-term follow-up in 4 unoperated patients showed that the calcium mass remained unchanged in 3; in the 4th patient, parathyroidectomy was carried out after the 18th month of follow-up. Her total body calcium fell by 16% before operation, but was nearly regained in the following 3 years. In 1 patient followed for 32 months after parathyroidectomy, the calcium mass remained unchanged. After a follow-up in 4 additional patients for an average of 15 months, the calcium mass remained unchanged in 3, whereas the 4th showed a significant decrease 12 months after the first measurement.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Total body calcium mass in primary hyperparathyroidism and long-term changes

et al. 1984

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“…The skeletal mineral uptake following PTX has been first studied in the 70s using total body neutron activation [11, 12, 13]. Pooling the patients of these three different studies does not lead to any firm conclusion: in 16 patients followed up to 3 years, the total body calcium content increased in 8 patients and decreased or remained stable in the other 8.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nasal Calcitonin on Bone Mineral Density following Parathyroidectomy in Patients with Primary Hyperparathyroidism

Casez¹,

Tschopp²,

Tschopp³

et al. 2003

Horm Res Paediatr

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Aim: To investigate whether nasal salmon calcitonin (CT; 200 U/day) given in addition to calcium helps to restore the bone mass after parathyroidectomy (PTX) in patients with primary hyperparathyroidism (PHPT). Methods: Twenty patients with PHPT were enrolled after successful PTX and received 1 g calcium per os daily for 1 year. They were randomly assigned either to nasal CT (CT group) or to no treatment. The bone mass was measured using dual-energy X-ray absorptiometry at multiple sites. Results: Eight patients in each group completed the study. After 12 months, the bone mass increased significantly at whole-body level and at lumbar spine in both groups, increased at hip and epiphyses of tibia or radius in the CT group only, and did not change at diaphyses of tibia and radius in either group. Conclusions: Bone mass increases after PTX for PHPT in patients receiving oral calcium. CT may help to restore the bone mass at sites of the appendicular skeleton, where trabecular bone predominates.

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Primary Hyperparathyroidism

Lafferty

Hubay²

1989

Arch Intern Med

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Alterations in Skeletal Calcium and Phosphorus in Dysfunction of the Parathyroids1

Cited by 19 publications

References 0 publications

Total body calcium mass in primary hyperparathyroidism and long-term changes

Total body calcium mass in primary hyperparathyroidism and long-term changes

Effects of Nasal Calcitonin on Bone Mineral Density following Parathyroidectomy in Patients with Primary Hyperparathyroidism

Primary Hyperparathyroidism

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