Alterations in serotonin metabolism in the irritable bowel syndrome

Thijssen, Ayla; Mujagic, Zlatan; Jonkers, Daisy; Ludidi, Samefko; Keszthelyi, Dániel; Hesselink, Martine; Clemens, Cees H.; Conchillo, José M.; Kruimel, Joanna W.; Masclee, Ad

doi:10.1111/apt.13459

Cited by 60 publications

(62 citation statements)

References 69 publications

(192 reference statements)

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“…[10][11][12][13][15][16][17][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] The baseline characteristics of included studies are shown in Table 1 22,29 Sphere score in 1 study, 24 and the Beck Anxiety Inventory (BAI) in 1 study. 30 …”

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

“…A total of six studies were included. 15,17,18,37,38,65 In those studies, healthy-control groups were used for multiple comparisons with the three IBS-subtypes; we divided the healthy-control group into three groups for meta-analysis of three IBS-subtypes alongside healthy controls. Depression levels were significantly higher in IBS-C (SMD = 0.83; 95% CI, 0.61-1.06; I 2 = 0%; P < 0.001), IBS-D (SMD = 0.73; 95% CI, 0.51-0.96; I 2 = 0%; P < 0.001), and IBS with mixed bowel habits (SMD = 0.62; 95% CI, 0.39-0.84; I 2 = 0%; P < 0.001) (Fig.…”

Section: Depression and Anxiety In Irritable Bowel Syndrome-subtypementioning

confidence: 99%

“…1,4,9 Animal studies have demonstrated the influence of stress on colonic permeability, and mucosal and systemic inflammation's mediation by the autonomic nervous system and the hypothalamo-pituitary-adrenal axis. 4 Several recently published studies have mapped IBS's relationship with psychological disorders [10][11][12][13][14][15][16] and compared depression and anxiety levels in IBS-subtypes. 15,17,18 However, the relationship between IBS and psychological disorders (depression or anxiety) was inconsistent, even in a recent meta-analysis entailing eight studies.…”

Section: Introductionmentioning

confidence: 99%

“…4 Several recently published studies have mapped IBS's relationship with psychological disorders [10][11][12][13][14][15][16] and compared depression and anxiety levels in IBS-subtypes. 15,17,18 However, the relationship between IBS and psychological disorders (depression or anxiety) was inconsistent, even in a recent meta-analysis entailing eight studies. 19 The heterogeneity of the results was too high, with no further analysis of its cause.…”

Section: Introductionmentioning

confidence: 99%

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The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Lee

Doo

Choi

et al. 2017

J Neurogastroenterol Motil

163

147

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Background/AimsIrritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. MethodsWe searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; subgroup analyses were conducted according to IBS-subtypes. ResultsIn total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62-0.90; P < 0.001; I 2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67-1.01; P < 0.001; I 2 = 85.6%, respectively). Both analyses' funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes. ConclusionsThe present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBSsubtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.

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Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Depression and Anxiety In Irritable Bowel Syndrome-subtypementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Lee

Doo

Choi

et al. 2017

J Neurogastroenterol Motil

163

147

View full text Add to dashboard Cite

show abstract

“…The latter seemed to be associated with duodenal immune activation, with increased numbers of IELs and mast cells being observed, and significant increases in tryptase release. Interestingly, in one study, alterations in 5-HT metabolism in 154 IBS patients did not seem to correlate with GI symptoms, or mood [84]. However, the technical issues of avoiding contamination from platelet release of 5-HT in these studies remain a concern.…”

Section: Evidence For the Role Of Abnormalities In 5-ht Metabolismmentioning

confidence: 99%

Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview

Holtmann

Shah

Morrison

2017

Dig Dis

120

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Background and Summary: Traditionally, functional gastrointestinal disorders (FGID), including functional dyspepsia or irritable bowel syndrome (IBS), are defined by more or less specific symptoms and the absence of structural or biochemical abnormalities that cause these symptoms. This concept is now considered to be outdated; if appropriate tests are applied, structural or biochemical abnormalities that explain or cause the symptoms may be found in many patients. Another feature of FGID are the highly prevalent psychiatric comorbidities, such as depression and anxiety. It is implied that mood disorders “cause” gastrointestinal symptoms. In fact, epidemiological data now provide strong evidence that in subsets of cases, gastrointestinal (GI) symptoms arise first and mood disorders occur later, while in other patients the reverse appears to happen. Possible mechanisms for gut-brain dysfunction have been identified, with systemic minimal inflammation as a causal factor in at least some subjects. Other mechanisms that play a role in FGID include chronic infections, intestinal microbiota, low-grade mucosal inflammation including the increase of eosinophils, systemic immune activation, altered intestinal permeability, in diarrhea predominant IBS altered bile salt metabolism, abnormalities in the serotonin metabolism and genetic factors. All these factors might be modulated by environmental factors such as diet. Key Messages: While a number of factors can be linked to specific symptoms (e.g., pain or diarrhea), it is evident that the symptom-based categorization of patients will not allow targeted treatments that specifically address the underlying pathophysiology.

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Rhubarb anthraquinone glycosides protect against cerebral ischemia‐reperfusion injury in rats by regulating brain–gut neurotransmitters

Guo

et al. 2021

Biomedical Chromatography

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Rhubarb anthraquinone glycosides (RAGs) have been proven to have significant therapeutic effects on ischemic stroke, and this effect may be related to the microbiome–gut–brain axis. In this study, an HPLC‐FLD method was established to measure brain–gut neurotransmitters of rats with cerebral ischemia‐reperfusion injury (CIRI), to explore whether the mechanism of RAGs against CIRI is related to the microbiome–gut–brain axis. A Shimadzu ODS‐3 C18 column was used for chromatographic separation, and 5‐hydroxytryptamine (5‐HT), 5‐hydroxy indole acetic acid (5‐HIAA), glutamic acid (Glu), aspartic acid (Asp), and γ‐aminobutyric acid (GABA) were determined simultaneously. The results showed that there is an excellent linear relationship (R2≥ 0.9990) and a high separation degree in the HPLC‐FLD method. Whereas the contents of Asp and Glu in the brain and colon increased (p < 0.05), the contents of 5‐HT, 5‐HIAA, and GABA in the brain and colon decreased (p < 0.05) after CIRI. RAGs could effectively reduce the contents of Asp and Glu (p < 0.05), and increase the contents of 5‐HT, 5‐HIAA, and GABA in the brain and colon (p < 0.05). Combined with the previous experimental results, we can speculate that RAGs can regulate intestinal flora disorder caused by CIRI, and then regulate the imbalance between the release and decomposition of neurotransmitters caused by intestinal flora disorder.

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Alterations in serotonin metabolism in the irritable bowel syndrome

Abstract: SUMMARY BackgroundAlterations in serotonin (5-HT) metabolism have been postulated to play a role in the pathogenesis of irritable bowel syndrome (IBS). However, previous reports regarding 5-HT metabolism in IBS are contradicting.

Cited by 60 publications

References 69 publications

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview

Rhubarb anthraquinone glycosides protect against cerebral ischemia‐reperfusion injury in rats by regulating brain–gut neurotransmitters

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