Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly

Markus, H.S.; Ring, Howard; Kouris, Kypros; Costa, D. C.

doi:10.1097/00006231-199308000-00002

Cited by 27 publications

(12 citation statements)

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“…For example, this is the case in early dementia, where small asymmetries may be present at the initial examination [22]. In accordance with literature data [23,24], a consistent rightward asymmetry was found in normal healthy brains.…”

Section: Discussionsupporting

confidence: 89%

Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras

et al. 2001

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A stereotactic, normal perfusion database is imperative for optimal clinical brain single-photon emission tomography (SPET). However, interdepartmental use of normal data necessitates accurate transferability of these data sets. The aim of this study was to investigate transfer of three normal perfusion databases obtained in the same large population of healthy volunteers who underwent sequential scanning using multihead gamma cameras with different resolution. Eighty-nine healthy adults (46 females, 43 males; aged 20-81 years) were thoroughly screened by history, biochemistry, physical and full neurological examination, neuropsychological testing and magnetic resonance imaging. After injection of 925 MBq technetium-99m labelled ethyl cysteinate dimer (ECD) under standard conditions, 101 scans were acquired from all subjects (12 repeat studies) on a triple-head Toshiba GCA-9300A (measured average FWHM 8.1 mm). Ninety-one sequential scans were performed on a dual-head Elscint Helix camera (FWHM 9.6 mm) and 22 subjects also underwent imaging on a triple-head Prism 3000 (FWHM 9.6 mm). Images were transferred to the same processing platform and reconstructed by filtered back-projection with the same Butterworth filter (order 8, cut-off 0.9 cycles/cm) and uniform Sorensen attenuation correction (mu = 0.09). After automated rigid intrasubject registration, all subjects were automatically reoriented to a stereotactic template by a nine-parameter affine transformation. The databases were analysed using 35 predefined volumes of interest (VOIs) with normalisation on total VOI counts. For comparison, the high-resolution data were smoothed with a 3D Gaussian kernel to achieve more similar spatial resolution. Hoffman phantom measurements were conducted on all cameras. Partial volume effects after smoothing varied between -6.5% and 10%, depending on VOI size. Between-camera reproducibility was 2.5% and 2.7% for the Toshiba camera versus the Helix and the Prism database, respectively. The highest reduction in between-camera variability was achieved by resolution adjustment in combination with linear washout correction and a Hoffman phantom-based correction. In conclusion, transfer of normal perfusion data between multihead gamma cameras can be accurately achieved, thereby enabling widespread interdepartmental use, which is likely to have a positive impact on the diagnostic capabilities of clinical brain perfusion SPET.

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Section: Discussionsupporting

confidence: 89%

Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras

et al. 2001

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“…Catafau et al (1996) showed a mixed left-right pattern of asymmetry in a cohort of control subjects of similar age to our ECD group, and a stronger rightward pattern in a much older cohort, suggesting that SPECT laterality becomes progressively rightward with increasing subject age. Other prior reports of rightward laterality with HMPAO or ECD SPECT tracers used subjects significantly older than (Baird et al, 1999;Lobaugh et al, 2000), or spanning a larger age range (Van Laere et al, 2001;Markus et al, 1993;Grova et al, 2003) than our cohort. Krausz et al (1998) showed a mixed pattern of laterality in a group of subjects spanning a wide range of ages.…”

Section: Discussionmentioning

confidence: 74%

“…Prior studies investigating lateral asymmetry in SPECT images of normal brain have used visual comparison (Aubert-Broche et al, 2005), manually placed or drawn region of interest (ROI) measurements (Markus et al, 1993;Catafau et al, 1996;Baird et al, 1999;Grova et al, 2003;Aubert-Broche et al, 2005), template-based ROI measurements (Krausz et al, 1998;Van Laere et al, 2001) or a two-compartment model (Risberg et al, 1975) to assess asymmetry. Prior studies have not, however, provided a comprehensive picture of the patterns of SPECT asymmetry.…”

Section: Introductionmentioning

confidence: 99%

Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Brinkmann

Jones

Stead

et al. 2011

J Cereb Blood Flow Metab

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Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.

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“…Age-related decline in cerebral blood flow and metabolism is commonly reported (e.g., Devous et al, 1986;Tanaka et al, 2000;Van Laere et al, 2001b;Waldemar et al, 1991), and several studies documented increases in left-right asymmetries with increasing age (Markus et al, 1993;Van Laere et al, 2001b;Waldemar et al, 1991;Yamaguchi et al, 1986). However, other studies found patterns of asymmetry to be age-invariant (Hagstadius and Risberg, 1989;Krausz et al, 1998).…”

Section: Discussionmentioning

confidence: 96%

Asymmetric regional cerebral blood flow in sedated baboons measured by positron emission tomography (PET)

Kaufman

Phillips‐Conroy

Black

et al. 2003

American J Phys Anthropol

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The analysis of structural brain asymmetry has been a focal point in anthropological theories of human brain evolution and the development of lateralized behaviors. While physiological brain asymmetries have been documented for humans and animals presenting with pathological conditions or under certain activation tasks, published studies on baseline asymmetries in healthy individuals have produced conflicting results. We tested for the presence of cerebral blood flow asymmetries in 7 healthy, sedated baboons using positron emission tomography, a method of in vivo autoradiography. Five of the 7 baboons exhibited hemispheric asymmetries in which left-sided flow was significantly greater than right-sided flow. Furthermore, the degree of asymmetry in 8 of 24 brain regions was found to be significantly correlated with age; older individuals exhibited a higher degree of asymmetry than younger individuals. Cerebral blood flow itself was uncorrelated with age, and differences between males and females were not significant.

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Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly

Cited by 27 publications

References 0 publications

Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras

Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras

Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Asymmetric regional cerebral blood flow in sedated baboons measured by positron emission tomography (PET)

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