Alterations in R–R variability associated with experimental motion sickness

Doweck, Ilana; Gordon, Carlos R.; Shlitner, Arie; Spitzer, Orna; Gonen, Adi; Binah, Ofer; Melamed, Yuval; Shupak, Avi

doi:10.1016/s0165-1838(97)00090-8

Cited by 47 publications

(29 citation statements)

References 12 publications

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“…The latter term has mainly been used to describe responses such as cold-sweating (Cheung et al, 2011; Hemingway, 1944; Nobel et al, 2012; Sclocco et al, 2015) and pallor (Cassano et al, 1989; Kolev et al, 1997) that often occur following exposure to emetic stimuli, which are mediated through the sympathetic nervous system (Hammam et al, 2012). However, other physiological changes may be associated with the pre-emetic stress response, including alterations in heart rate variability (Doweck et al, 1997; Kim et al, 2011; Kim et al, 2005) and a release of vasopressin from the posterior pituitary (Fisher et al, 1982; Robertson, 1976; Rowe et al, 1979; Sorensen et al, 1985). Along with these physiological responses are a number of perceptions with accompanying behavioral changes (Graybiel et al, 1968; Muth et al, 1996), including an awareness that stomach emptying is imminent, loss of appetite (Farmer et al, 2015; Heer et al, 2006; Hiura et al, 2012; Lackner, 2014; Sanger et al, 2013), anxiety and foreboding (Coelho et al, 2015; Fox et al, 1988; Lackner, 2014; Tarbell et al, 2014), as well as lethargy and disinterest in engaging in routine activities (Graybiel et al, 1976; Lackner, 2014; Lawson et al, 1998; Matsangas et al, 2014; Van Ombergen et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

What is nausea? A historical analysis of changing views

Balaban

Yates

2017

Autonomic Neuroscience

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The connotation of “nausea” has changed across several millennia. The medical term ‘nausea’ is derived from the classical Greek terms ναυτια and ναυσια, which designated the signs and symptoms of seasickness. In classical texts, nausea referred to a wide range of perceptions and actions, including lethargy and disengagement, headache (migraine), and anorexia, with an awareness that vomiting was imminent only when the condition was severe. However, some recent articles have limited the definition to the sensations that immediately precede emesis. Defining nausea is complicated by the fact that it has many triggers, and can build-up slowly or rapidly, such that the prodromal signs and symptoms can vary. In particular, disengagement responses referred to as the “sopite syndrome” are typically present only when emetic stimuli are moderately provocative, and do not quickly culminate in vomiting or disengagement from the triggering event. This review considers how the definition of “nausea” has evolved over time, and summarizes the physiological changes that occur prior to vomiting that may be indicative of nausea. Also described are differences in the perception of nausea, as well as the accompanying physiological responses, that occur with varying stimuli. This information is synthesized to provide an operational definition of nausea.

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Section: Introductionmentioning

confidence: 99%

What is nausea? A historical analysis of changing views

Balaban

Yates

2017

Autonomic Neuroscience

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“…However, it has not been determined whether the difference can be correlated with susceptibility to MS. It was reported in one study [7] that the development of MS is accompanied by an increase in sympathetic activity and a decrease in parasympathetic activity, and that adaptation to MS is accompanied by the recovery of autonomic nervous system balance. Although it is still a matter of controversy whether or not the changes that occur during the time course of MS are mediated by the sympathetic or parasympathetic systems, a sympathovagal index may be useful in predicting the severity of MS [8].…”

Section: Introductionmentioning

confidence: 99%

Motion sickness susceptibility associated with visually induced postural instability and cardiac autonomic responses in healthy subjects

Yokota

Aoki

Mizuta

et al. 2005

Acta Oto-Laryngologica

117

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In subjects with a low susceptibility to motion sickness as rated using a standardized questionnaire, there was no significant effect of visual stimulus on postural sway or HRV at any frequency of motion. Subjects with a high susceptibility to motion sickness showed significant postural instability induced by visual stimuli (p < 0.01). Visual stimuli presented at a frequency of 0.1 Hz significantly increased the low-frequency power (LF) of HRV, decreased the high-frequency power (HF) of HRV and increased the LF:HF ratio in these subjects (p < 0.05).

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“…Given the same motion stimulus, however, there are individual differences in the occurrence and severity of motion sickness symptoms. A number of studies indicate that the development of motion sickness may be mediated, in part, by increased sympathetic and decreased parasympathetic nervous system activity: The report of motion sickness, for example, has been associated with increases in skin conductance and plasma catecholamines (Hu, Grant, Stern, & Koch, 1991;Koch et al, 1990;Kohl, 1993) and decreases in heart period variability (Doweck et al, 1997;Hu et al, 1991;Uijtdehaage, Stern, & Koch, 1992, 1993. Furthermore, effective interventions for motion sickness inhibit sympathetic activation and enhance or maintain parasympathetic activity during motion exposure (Hasler et al, 1995;Kohl & Homick, 1983;Uijtdehaage et al, 1992Uijtdehaage et al, , 1993.…”

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confidence: 99%

Relationship between temporal changes in cardiac parasympathetic activity and motion sickness severity

Gianaros

Quigley²,

Muth

et al. 2003

Psychophysiology

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Chemotherapy-induced nausea has been associated with a time-related decrease in cardiac parasympathetic activity. We tested the hypothesis that a time-related decrease in cardiac parasympathetic activity would also be associated with nausea and other motion sickness symptoms during illusory self-motion (vection). Fifty-nine participants (aged 18-34 years: 25 male) were exposed to a rotating optokinetic drum to induce vection. Symptoms of motion sickness and an estimate of cardiac parasympathetic activity (respiratory sinus arrhythmia; RSA) were obtained at baseline and throughout a drum-rotation period. As expected, motion sickness symptoms increased and RSA decreased over time during drum rotation. Moreover, greater decreases in RSA over time correlated with greater motion sickness severity. These results suggest that a time-related decrease in cardiac parasympathetic activity may be an important correlate of nausea and motion sickness across different evocative contexts.

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Alterations in R–R variability associated with experimental motion sickness

Cited by 47 publications

References 12 publications

What is nausea? A historical analysis of changing views

What is nausea? A historical analysis of changing views

Motion sickness susceptibility associated with visually induced postural instability and cardiac autonomic responses in healthy subjects

Relationship between temporal changes in cardiac parasympathetic activity and motion sickness severity

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