Alterations in prostaglandin catabolism in rats chronically dosed with ethanol

Pennington, Sam N.; Smith, Carlton; Strider, John B.

doi:10.1016/0006-2944(79)90079-6

Cited by 20 publications

(2 citation statements)

References 8 publications

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“…Similar changes in PGDH are observed in fetuses delivered by drinking mothers [10,11]. While attempting to determine a dose/response relationship between ethanol and changes in PGDH activity, we had ob served that such changes were related more closely to peak blood ethanol values than to total ethanol dose.…”

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confidence: 87%

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Fetal 15-Hydroxyprostaglandin Dehydrogenase Is Altered by Maternal Ethanol Exposure

Pennington¹,

Rumbley²,

Woody³

1981

Neonatology

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Several studies have suggested that ethanol consumption may alter prostaglandin metabolism and that this alteration may represent the molecular mechanism underlying certain of the pathophysiological consequences of chronic alcoholism. Our laboratory is investigating the hypothesis that ethanol induced changes in prostaglandin metabolism may be volved in the etiology of the condition termed fetal alcohol syndrome. In this study, pregnant rats (Holtzman) were exposed for 2 h each day throughout gestation to ethanol by vapor inhalation. Ethanol exposure resulted in retarded fetal growth and changes in the prostaglandin dehydrogenase activity in homogenates from placental amnion and maternal and fetal kidney.

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confidence: 87%

“…Direct and indirect interactions between ethanol and PG function and metabolism have shown to oc cur in brain [4], lung and kidney [11). stom ach [7], uterus [6], blood vessels [2], and platelets [8] of several animal species.…”

mentioning

confidence: 99%

Fetal 15-Hydroxyprostaglandin Dehydrogenase Is Altered by Maternal Ethanol Exposure

Pennington¹,

Rumbley²,

Woody³

1981

Neonatology

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Craniofacial alterations in adult rats prenatally exposed to ethanol

Edwards

Dow-Edwards

1991

Teratology

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The rat was studied to determine whether gestational exposure to moderate amounts of ethanol produces permanent craniofacial malformations. Pregnant Long-Evans rats were fed a liquid diet containing 35% ethanol-derived calories or an isocaloric liquid diet between gestation days 6 and 20. Various dimensions of skulls and mandibles from adult male offspring were measured. All measurements taken in the parasagittal and coronal planes were significantly smaller in the ethanol-exposed rats than in the offspring of pair-fed controls. None of the vertical measurements was significantly altered. This report demonstrates that gestational exposure to ethanol in rats, at doses which produce lasting behavioral effects, also produces a specific constellation of craniofacial dysmorphisms without concomitant decreases in body weight.

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Alkohol und Niere

Keller¹,

Ritz²

Alkohol Und Alkoholfolgekrankheiten

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Alterations in prostaglandin catabolism in rats chronically dosed with ethanol

Cited by 20 publications

References 8 publications

Fetal 15-Hydroxyprostaglandin Dehydrogenase Is Altered by Maternal Ethanol Exposure

Fetal 15-Hydroxyprostaglandin Dehydrogenase Is Altered by Maternal Ethanol Exposure

Craniofacial alterations in adult rats prenatally exposed to ethanol

Alkohol und Niere

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