Alterations in portal vein blood pH, hepatic functions, and hepatic histology in a porcine carbon dioxide pneumoperitoneum model

Yoshida, Makoto; Ikeda, Satoshi; Sumitani, Daisuke; Takakura, Yuji; Yoshimitsu, Masanori; Shimomura, Manabu; Noma, Midori; Tokunaga, Masahito; Okajima, Masazumi; Ohdan, Hideki

doi:10.1007/s00464-009-0831-6

Cited by 11 publications

(20 citation statements)

References 27 publications

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“…On the other hand, one of the most significant hemodynamic effects is the reduction of the splachnic perfusion. Alterations in the portal vein and hepatic vein flows have been as well described due to the pressure increase (10, 11). Different authors conclude that these alterations in the hepatic flow result in an increase of the hepatic enzymes (12, 13).…”

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confidence: 99%

Effects of pneumoperitoneum and body position on the morphology of abdominal vascular structures analyzed in MRI

Moyano-Cuevas

Sánchez‐Margallo

Maestre-Antequera

et al. 2012

Magnetic Resonance Imaging

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Purpose: To analyze the complications of laparoscopy in different vascular structures using magnetic resonance imaging (MRI). MRI has become a key tool in laparoscopic surgery. During these procedures, pneumoperitoneum creation and placing the patient in the surgical position provoke different changes in the splachnic circulation. Materials and Methods:Ten pigs were included in the study. MRI studies of the abdominal area were carried out in four different situations of abdominal pressure and body position.Results: Changes in the area of the lumen of the portal vein and the abdominal aorta were analyzed in all situations. A significant reduction in the area of the abdominal aorta was observed after the pneumoperitoneum in supine and anti-Trendelemburg position. The lumen of the portal vein was significantly reduced in all analyzed situations except when placing the patient in anti-Trendelemburg without pneumoperitoneum, in which case the area was increased. Conclusion:The creation of pneumoperitoneum provokes morphological changes in the lumen of different abdominal vessels as a consequence of the increase of pressure. Furthermore, the combination of pneumoperitoneum together with the anti-Trendelemburg position results in a more significant reduction of the lumen of the portal vein and the abdominal aorta.

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mentioning

confidence: 99%

Effects of pneumoperitoneum and body position on the morphology of abdominal vascular structures analyzed in MRI

Moyano-Cuevas

Sánchez‐Margallo

Maestre-Antequera

et al. 2012

Magnetic Resonance Imaging

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“…In addition, pneumoperitoneum increase from 10 to 15 mm Hg can decrease liver flow by 39%, causing liver ischemia injury, and deflation after surgery resulting in blood reperfusion results in liver ischemia reperfusion injury [ 32 , 33 ]. Several studies showed that CO 2 pneumoperitoneum affects liver enzyme function and causes tissue injury [ 34 , 35 ]. Our results showed a similar result.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats

Chen

Jiang

et al. 2017

Oncotarget

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The aim of the current study was to identify the protective effect of hydrogen gas against liver injury during CO2 pneumoperitoneum. Rats were randomly divided into three groups: control group (C group), pneumoperitoneum group (P15 group) and hydrogen group (H2 group). Rats in the C group were subjected to anesthesia for 90 min. Rats in the P15 group received an abdominal insufflation of CO2 for 90 min at an intra-abdominal pressure of 15 mmHg. Rats in the H2 group received a hypodermic injection of hydrogen gas (0.2 mL/kg) and after 10 min they received an abdominal insufflation of CO2 for 90 min at an intra-abdominal pressure of 15 mmHg. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured to evaluate liver function. Malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) content were measured to evaluate oxidative stress. Nuclear factor E2-related factor 2 (Nrf2) and Nrf2 downstream target genes, apoptosis-related genes and inflammatory cytokine mRNA and protein expression were detected. Liver injury was detected under the microscope. Our results revealed that liver function, antioxidants content, inflammation and liver injury were improved after hydrogen preconditioning in H2 group compared with P15 group. Overall, our results revealed that subcutaneous hydrogen injection could exert a protective effect against liver injury during CO2 pneumoperitoneum through reducing oxidative stress, cell apoptosis and inflammatory cytokines release.

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“…Several studies have described the effects of CO 2 pneumoperitoneum on intra-abdominal blood flow and reported diminished blood flow in the portal vein and the hepatic artery [26,27]. On the other hand, recent report suggests that prolonged pneumoperitoneum for about 6 hours does not hamper liver function or cause liver damage after extended laparoscopic procedures [28].…”

Section: Discussionmentioning

confidence: 99%

Saline-filled laparoscopic surgery: A basic study on partial hepatectomy in a rabbit model

Shimada

Kawaguchi

Ishikawa

et al. 2014

Minimally Invasive Therapy & Allied Technologies

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Alterations in portal vein blood pH, hepatic functions, and hepatic histology in a porcine carbon dioxide pneumoperitoneum model

Cited by 11 publications

References 27 publications

Effects of pneumoperitoneum and body position on the morphology of abdominal vascular structures analyzed in MRI

Effects of pneumoperitoneum and body position on the morphology of abdominal vascular structures analyzed in MRI

Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats

Saline-filled laparoscopic surgery: A basic study on partial hepatectomy in a rabbit model

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