Alterations in neurotransmitter levels and transcription factor expression following intranasal buprenorphine administration

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

“…There have been no studies on the relation between P 2 X 4 or GABA A gene expression changes under the influence of BUP, which indicates the novelty of our research. Yet, regarding the effect of BUP on GABA A receptor expression following opioid addiction, it has been demonstrated that BUP enhances GABA expression while decreasing DA, implying that it can attenuate the neurotransmitter alterations seen in opioid dependence [ 47 ].…”