Alterations in neurobehaviors and inflammation in hippocampus of rats induced by oral administration of microcystin-LR

Li, Xiaobo; Zhang, Xin; Ju, Jingjuan; Li, Yunhui; Yin, Lihong; Pu, Yuepu

doi:10.1007/s11356-014-3151-x

Cited by 32 publications

(22 citation statements)

References 38 publications

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“…Prolonged MC‐LR exposure increases the levels of total lipids, polar lipids, and neutral lipids in rat plasma . In our previous study, serum cholinesterase, an early marker of liver steatosis, increased even at low MC‐LR exposure levels in male rats . Therefore, we speculated that the rat body weight exhibited an increasing tendency after prolonged MC‐LR exposure.…”

Section: Discussionmentioning

confidence: 87%

Maternal repeated oral exposure to microcystin‐LR affects neurobehaviors in developing rats

Zhang²,

Ju³

et al. 2014

Enviro Toxic and Chemistry

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Microcystins are toxic peptides secreted by certain water blooms of toxic cyanobacteria. The most widely studied microcystin is microcystin-LR (MC-LR), which exhibits hepatotoxicity and neurotoxicity. However, limited information is available regarding the effects on offspring following maternal exposure. The present study was conducted to observe the effects of progestational exposure to MC-LR on postnatal development in rats. Female Sprague-Dawley rats (28 d old) were randomly divided into a control group and 3 treatment groups (1.0 µg MC-LR/kg body wt, 5.0 µg MC-LR/kg body wt, and 20.0 µg MC-LR/kg body wt), with 7 rats per group. The MC-LR was administered through gavage once every 48 h for 8 wk. Pure water was used as control. Each female rat was mated with an unexposed adult male rat. Motor development, behavioral development, and learning ability of pups were detected using surface righting reflex, negative geotaxis, and cliff avoidance tests on postnatal day 7. Open-field and Morris water maze tests were performed on postnatal day 28 and day 60. The levels of lipid peroxidation products and antioxidant indices in the rat hippocampus were also detected. Pups from the MC-LR-treated groups had significantly lower scores than controls in the cliff avoidance test (p < 0.05). Cognitive impairment, malondialdehyde level, and total superoxide dismutase activity significantly increased in MC-LR-exposed pups compared with controls (p < 0.05). Therefore, the present study reveals that maternal exposure to MC-LR has adverse effects on neurodevelopment in rat offspring.

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Section: Discussionmentioning

confidence: 87%

Maternal repeated oral exposure to microcystin‐LR affects neurobehaviors in developing rats

Zhang²,

Ju³

et al. 2014

Enviro Toxic and Chemistry

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“…Of note for risk analysis are those studies that examine effects from repeat oral dose exposures. In a recent study, Li et al [168] exposed rats orally to MCLR (0.2, 1.0, and 5.0 µg/kg·b.w.) by intragastric gavage for 8 weeks every two days and measured liver serum enzymes and effects on neurobehavior, or learning using the Morris water maze test.…”

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water

et al. 2017

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Cyanobacteria are ubiquitous phototrophic bacteria that inhabit diverse environments across the planet. Seasonally, they dominate many eutrophic lakes impacted by excess nitrogen (N) and phosphorus (P) forming dense accumulations of biomass known as cyanobacterial harmful algal blooms or cyanoHABs. Their dominance in eutrophic lakes is attributed to a variety of unique adaptations including N and P concentrating mechanisms, N 2 fixation, colony formation that inhibits predation, vertical movement via gas vesicles, and the production of toxic or otherwise bioactive molecules. While some of these molecules have been explored for their medicinal benefits, others are potent toxins harmful to humans, animals, and other wildlife known as cyanotoxins. In humans these cyanotoxins affect various tissues, including the liver, central and peripheral nervous system, kidneys, and reproductive organs among others. They induce acute effects at low doses in the parts-per-billion range and some are tumor promoters linked to chronic diseases such as liver and colorectal cancer. The occurrence of cyanoHABs and cyanotoxins in lakes presents challenges for maintaining safe recreational aquatic environments and the production of potable drinking water. CyanoHABs are a growing problem in the North American (Laurentian) Great Lakes basin. This review summarizes information on the occurrence of cyanoHABs in the Great Lakes, toxicological effects of cyanotoxins, and appropriate numerical limits on cyanotoxins in finished drinking water.

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“…Of note for risk analysis are those studies that examine effects from repeat oral dose exposures. In a recent study, Li et al [156] exposed rats orally to MCLR (0. Malondialdehyde contents and superoxide dismutase activity were significantly higher in the highest exposure groups.…”

Section: Effects On Other Tissues From Oral Exposure To Mcsmentioning

confidence: 99%

Cyanobacterial Toxins of the Laurentian Great Lakes, their Toxicological Effects, and Numerical Limits in Drinking Water

Miller

Beversdorf

Weirich

et al. 2017

Preprint

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Cyanobacteria are ubiquitous phototrophic bacteria that inhabit diverse environments across the planet. They dominate many eutrophic lakes impacted by excess nitrogen (N) and phosphorus (P) forming dense accumulations of biomass known as cyanobacterial harmful algal blooms or cyanoHABs. Their dominance in eutrophic lakes is attributed to a variety of unique adaptations including N and P concentrating mechanisms, N fixation, colony formation that inhibits predation, vertical movement via gas vesicles, and the production of toxic or otherwise bioactive molecules. While some of these molecules have been explored for their medicinal benefits, others are potent toxins harmful to humans, animals, and other wildlife known as cyanotoxins. In humans these cyanotoxins affect various tissues, including the liver, central and peripheral nervous system, kidneys, and reproductive organs among others. They induce acute effects at low doses in the parts-per-billion range and some are tumor promoters linked to chronic diseases such as liver and colorectal cancer. The occurrence of cyanoHABs and cyanotoxins in lakes presents challenges for maintaining safe recreational aquatic environments and the production of potable drinking water. CyanoHABs are a growing problem in the North American (Laurentian) Great Lakes basin. This review summarizes information on the occurrence of cyanoHABs in the Great Lakes, toxicological effects of cyanotoxins, and appropriate numerical limits on cyanotoxins in finished drinking water.

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Alterations in neurobehaviors and inflammation in hippocampus of rats induced by oral administration of microcystin-LR

Cited by 32 publications

References 38 publications

Maternal repeated oral exposure to microcystin‐LR affects neurobehaviors in developing rats

Maternal repeated oral exposure to microcystin‐LR affects neurobehaviors in developing rats

Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water

Cyanobacterial Toxins of the Laurentian Great Lakes, their Toxicological Effects, and Numerical Limits in Drinking Water

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