Alterations in myocardial stiffness in elite athletes assessed by a new Doppler index

King, Gerard; Murphy, Ross T.; Almuntaser, Ibraham; Bennett, Kathleen; Ho, Emily; Brown, Angie

doi:10.1136/hrt.2008.142083

Cited by 30 publications

(25 citation statements)

References 20 publications

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“…Although, the number of studied cases are too small too draw a statistically significant conclusion, this difference in cardiac stiffness might be a confirmation on age dependency of left ventricular function, 53 particularly corroborating that the heart gets stiffer and less compliant with age. 20,29,39 Additionally, we found that the slope of the viscous damping functions follow similar patterns for each individual age group (Fig. 8).…”

Section: Effect Of Agingsupporting

confidence: 52%

Modeling Radial Viscoelastic Behavior of Left Ventricle Based on MRI Tissue Phase Mapping

et al. 2010

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The viscoelastic behavior of myocardial tissue is a measure that has recently found to be a deterministic factor in quality of contraction. Parameters imposing the viscoelastic behavior of the heart are influenced in part by sarcomere function and myocardial composition. Despite the overall agreement on significance of cardiac viscoelasticity, a practical model that can measure and characterize the viscoelastic behavior of the myocardial segments does not yet exist. Pressure-Volume (P-V) curves are currently the only measure for stiffness/compliance of the left ventricle. However, obtaining P-V curves requires invasive cardiac catheterization, and only provides qualitative information on how pressure and volume change with respect to each other. For accurate assessment of myocardial mechanical behavior, it is required to obtain quantitative measures for viscoelasticity. In this work, we have devised a model that yields myocardial elastic and viscous damping coefficient functions through the cardiac cycle. The required inputs for this model are kinematic information with respect to changes in LV short axes that were obtained by Magnetic Resonance Imaging (MRI) using a tissue phase mapping (TPM) pulse sequence. We evaluated viscoelastic coefficients of LV myocardium in two different age groups of 20-40 and greater than 60. We found that the magnitude of stiffness coefficients is noticeably greater in the older subjects. Additionally, we found that slope of viscous damping functions follow similar patterns for each individual age group. This method may shed light on dynamics of contraction through MRI in conditions where composition of myocardium is changed such as in aging, adverse remodeling, and cardiomyopathies.

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Section: Effect Of Agingsupporting

confidence: 52%

Modeling Radial Viscoelastic Behavior of Left Ventricle Based on MRI Tissue Phase Mapping

et al. 2010

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“…Stroke volume was calculated by using the aortic valve pulsed wave Doppler method whereby the velocity time integral of aortic annular flow was obtained by tracing the pulsed Doppler profile and multiplied by the area of the aortic annulus as previously described (30). Pre-load recruitable stroke work index, peak power index, single beat estimated end-systolic elastance, arterial elastance (31-33), chamber stiffness (34), pressure volume ratio (35), and longitudinal reserve indexes (36) were calculated:…”

Section: -Dimensional and Tissue Doppler Echocardiographymentioning

confidence: 99%

The Pathophysiology of Heart Failure With Normal Ejection Fraction

Tan

Wenzelburger

Lee

et al. 2009

Journal of the American College of Cardiology

436

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“…The mean values of Ea velocities were used to calculate the E/Ea ratio. Myocardial diastolic stiffness index was calculated using the equation of (Stiffness index = [(E/Ea)/LVIDd]) [14].…”

Section: Methodsmentioning

confidence: 99%

The Use of Left Ventricular Myocardial Stiffness Index as a Predictor of Myocardial Performance in Patients with Systemic Hypertension

Hussein¹,

Al-Mashhadani²,

Essa³

2014

IJMPCERO

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Our aim was to investigate the changes in the myocardium stiffness index for patients suffering from systemic hypertension, and to assess their left ventricular performance. We studied 263 hypertensive patients and 166 healthy subjects as a control group. By using conventional Doppler echocardiography, the following parameters were measured-Left ventricular end diastolic diameter, left ventricular end systolic diameter, transmitral early velocity, isovolumic relaxation time, and isovolumic contraction time. Tissue Doppler imaging (TDI) was used in the measurements of the early mitral annular velocity (Ea) and the diastolic stiffness was obtained by calculating the ratio E\Ea\LVIDd. Index myocardial performance (IMP) was calculated according to following equation (IVCT + IVRT)/ET for both the control group and hypertensive group. Results reveal that the differences in the average value of transmitral early filling velocity (E) between patients and control groups for age range (20 -49) and (50 -80) were (−1.91%) and (−3.69%) respectively with p value >0.05 for both groups, and the changes in LVIDd between patients and control groups were 0.42% and 1.29% for age ranges (20 -49) and (50 -80) respectively with p value >0.05 for both age groups. A significant difference in IMP between patients and controls has also been observed and the changes were 29.54% and 30.43% for age range (20 -49) and (50 -80) respectively with p value <0.05 for both groups. The mean values for E/Ea ratio and for the measured LV stiffness index were significantly higher in hypertensive patients compared with control group (p value < 0.05) for both age groups. In conclusion, LV myocardial diastolic stiffness index and IMP are increased in hypertensive patients.M. F. Hussein et al.

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Alterations in myocardial stiffness in elite athletes assessed by a new Doppler index

Abstract: Intense training reduces myocardial stiffness despite the development of LVH.

Cited by 30 publications

References 20 publications

Modeling Radial Viscoelastic Behavior of Left Ventricle Based on MRI Tissue Phase Mapping

Modeling Radial Viscoelastic Behavior of Left Ventricle Based on MRI Tissue Phase Mapping

The Pathophysiology of Heart Failure With Normal Ejection Fraction

The Use of Left Ventricular Myocardial Stiffness Index as a Predictor of Myocardial Performance in Patients with Systemic Hypertension

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