Alterations in mice dopamine receptor characteristics after early exposure to phenobarbital

Iser-Strenger, Carmela; Yanai, Joseph

doi:10.1016/0165-3806(86)90130-6

Cited by 7 publications

References 39 publications

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Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice

et al. 1989

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Pregnant C57BL/6J and CBA mice were administered 60 mg/kg phenobarbital intraperitoneally from days 10 to 16 of gestation. On day 18 of pregnancy half of the control and drug-treated mice were killed and the embryonic brains removed for cell cultures. The remaining mice were allowed to have their litter. After cross-fostering the mice were used for behavioural studies. Pups born to drug-treated CBA mice had birth-weights similar to controls, but their weights had fallen behind controls by day 18 after birth. They were slower at attaining mature responses in tests for sensory motor development and became progressively more hyperactive (three times more active at day 18) compared to controls. Drug-exposed C57 pups also had birth weights similar to controls. After cross-fostering, 19% of control and 31% of drug-exposed pups died, but the remaining drug-exposed pups showed no deficits in weight gain. In contrast to drug-treated CBA pups, drug-exposed C57 pups were slightly quicker in attaining mature responses in some tests. There was no difference in activity between them and their controls. In neurochemical analyses, uptake of neurotransmitters by cerebral cultures from CBA showed that uptake of GABA was increased by 5%, choline by 95%, dopamine 120%, serotonin 165% and noradrenaline by 160% in cultures from drug exposed embryos compared to controls. In cerebral cultures from C57, GABA uptake was reduced by 18%, choline 33%, dopamine 35% and noradrenaline by 25%. Only serotonin uptake was increased by 182% compared to controls. Differences between C57 and CBA were also apparent in the uptake of neurotransmitters by neuronal cultures from the mesencephalon.(ABSTRACT TRUNCATED AT 250 WORDS)

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Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice

et al. 1989

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Alterations in hippocampal cholinergic receptors and hippocampal behaviors after early exposure to nicotine

Yanai¹,

Pick²,

Rogel-Fuchs³

et al. 1992

Brain Research Bulletin

100

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Normal zinc and iron concentrations in mice after early exposure to phenobarbital

Pick¹,

Statter

Shachar

et al. 1987

Intl J of Devlp Neuroscience

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Zinc and iron levels were studied in mice with early (pre/neonatal) exposure to phenobarbital, as the levels of these trace metals are known to be correlated with specific behaviors shown in our previous and present experiment to be affected by early phenobarbital administration. Mice were exposed to phenobarbital prenatally or neonatally. At adulthood they showed marked reduction from control in all parameters of eight-arm maze performance (P less than 0.001). Since zinc is known to be correlated with this behavior, it was subsequently studied in barbiturate exposed animals. The differences between barbiturate exposed and control offspring for zinc levels in plasma, brain and hippocampus did not reach statistical significance. Our previous studies have shown that the number of dopamine receptors and the resulting apomorphine-induced climbing behavior is altered after early exposure to phenobarbital. The effect of iron level on dopamine receptors is now well established. Subsequently, a group of mice were tested for iron levels in their brain and liver. No significant differences were found. It is suggested that deficits in the hippocampal behaviors, mainly eight-arm maze, after early exposure to phenobarbital are not related to changes in zinc levels. Similarly, early phenobarbital-induced alternation in dopamine receptors and the resulting dopaminergic behaviors are not related to changes in iron levels.

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Alterations in mice dopamine receptor characteristics after early exposure to phenobarbital

Cited by 7 publications

References 39 publications

Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice

Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice

Alterations in hippocampal cholinergic receptors and hippocampal behaviors after early exposure to nicotine

Normal zinc and iron concentrations in mice after early exposure to phenobarbital

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