Alterations in maternal and fetal prostaglandin dehydrogenase as a result of maternal ethanol consumption

Pennington, Sam N.; Smith, Carlton; Strider, John B.

doi:10.1016/0161-4630(80)90093-2

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…The response of PGDH of maternal kid ney, fetal kidney and amnion to ethanol dos ing via vapor inhalation was similar to those reported for other dosing methods [10]. Preg nancy markedly lowered PGDH activity rela tive to nonpregnant controls and this de crease was enhanced by ethanol exposure.…”

Section: Resultssupporting

confidence: 61%

“…We had previously reported that ethanol consumption by the mother lowered amnion PGDH activity from the placenta isolated on day 21 of the pregnancy [10]. As shown in figure 4 the effect of ethanol vapor inhalation by the mother on PGDH activity appears to be biphasic with respect to the amnion PGDH.…”

Section: Resultsmentioning

confidence: 79%

“…Similar changes in PGDH are observed in fetuses delivered by drinking mothers [10,11]. While attempting to determine a dose/response relationship between ethanol and changes in PGDH activity, we had ob served that such changes were related more closely to peak blood ethanol values than to total ethanol dose.…”

mentioning

confidence: 89%

“…Radioactive spots were identified by comparison with known standards run on the same plate and were scraped and quantitated by liquid scin tillation counting (Beckman Model LS-233). This pro cedure gave good recoveries and worked well for all homogenates [10]. The purity of the commercial re labeled PGs was checked by chromatography.…”

Section: /I Wa R O F Pgdhmentioning

confidence: 99%

“…Numerous papers have described re tardation of fetal growth and development in humans and animal models when the mother consumes ethanol during the pregnancy [5], Similarly, P(Js and PG metabolism have been suggested to influence fetal growth and development [9], Maternal ethanol consump tion during pregnancy has been shown to alter fetal PG metabolism [10] and thus might be implicated in the molecular mecha nism for the development of the fetal alcohol syndrome.…”

mentioning

confidence: 99%

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Fetal 15-Hydroxyprostaglandin Dehydrogenase Is Altered by Maternal Ethanol Exposure

Pennington¹,

Rumbley²,

Woody³

1981

Neonatology

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Several studies have suggested that ethanol consumption may alter prostaglandin metabolism and that this alteration may represent the molecular mechanism underlying certain of the pathophysiological consequences of chronic alcoholism. Our laboratory is investigating the hypothesis that ethanol induced changes in prostaglandin metabolism may be volved in the etiology of the condition termed fetal alcohol syndrome. In this study, pregnant rats (Holtzman) were exposed for 2 h each day throughout gestation to ethanol by vapor inhalation. Ethanol exposure resulted in retarded fetal growth and changes in the prostaglandin dehydrogenase activity in homogenates from placental amnion and maternal and fetal kidney.

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Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 79%

mentioning

confidence: 89%

Section: /I Wa R O F Pgdhmentioning

confidence: 99%

mentioning

confidence: 99%

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