Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4

Taub, Dennis D.; Mikovits, Judy A.; Nilsson, Gunnar; Schaffer, Eric; Key, Michael L.; Petrow‐Sadowski, Cari; Ruscetti, Francis W.

doi:10.1016/j.cellimm.2004.09.005

Cited by 19 publications

(21 citation statements)

References 56 publications

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“…Other authors reported, by determining the p24 antigen in the cell-free culture supernatants, that HIV-1 can replicate in HMC-1. Interestingly, SCF treatment did modestly increase viral p24 levels on day 56 on the HMC-1 [22]. These findings have laid the groundwork of a model for mast cells as long-lived sanctuary for persistent HIV infection.…”

mentioning

confidence: 83%

“…The CCR5-specific inhibitor significantly reduced the infection whereas blocking the CCR3 or CXCR4 molecules only slightly decreased virus entry or have no effect, respectively. In contrast, Taub et al [22] reported that CD4 + , CXCR4 + and CCR5 -human mast cell (HMC)-1 line was susceptible to X4-but not R5-tropic strain, while CD4 + , CXCR4 + and CCR5 + primary mast cells were productively infected by either X4-and R5-tropic viruses. Interestingly, surface expression of CD4 molecule for both investigated mast cell populations was very low.…”

mentioning

confidence: 98%

“…Transforming growth factor (TGF)-β1 and tumor necrosis factor (TNF), cytokines overexpressed in AIDS individuals, upregulate surface expression of CCR5 and CD4 on HMC-1 as well as CCR5 and CXCR4 on primary mast cells [22]. HMC-1 preincubated with TGF-β1 or TNF are more susceptible to X4-and R5-tropic viruses.…”

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confidence: 99%

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Are mast cells the Trojan horse in HIV-1 infection?

Witczak¹,

Brzezińska‐Błaszczyk²

2012

cejoi

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mentioning

confidence: 83%

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confidence: 98%

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Are mast cells the Trojan horse in HIV-1 infection?

Witczak¹,

Brzezińska‐Błaszczyk²

2012

cejoi

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“…Regarding their role in HIV infection, human mast cells can be infected in vitro and probably in vivo by certain HIV strains [59,60,61,62,63,64,65]. By contrast, there is no evidence that human basophils can be infected by HIV [73].…”

Section: Differential Role Of Human Basophils and Mast Cells In Hiv Imentioning

confidence: 99%

“…These results suggest that human mast cells may serve both as a viral reservoir and as a model of latency in HIV infection. Certain strains of HIV can infect also the human mast cell line HMC-1 through the interaction with CXCR4 [63]. In addition, mast cells cultured in vitro from circulating CD34 + pluripotent progenitors, but not mature mast cells, are susceptible to HIV infection [64].…”

Section: Can Human Basophils and Mast Cells Be Infected By Hiv?mentioning

confidence: 99%

Are Basophils and Mast Cells Masters in HIV Infection?

Marone

Varricchi²,

Loffredo³

et al. 2016

Int Arch Allergy Immunol

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The World Health Organization AIDS epidemic update estimates that more than 37 million people are living with HIV infection. Despite the unprecedented success of antiretroviral treatments, significant challenges remain in the fight against HIV. In particular, how uninfected cells capture HIV and transmit virions to target cells remains an unanswered question. Tissue mast cells and peripheral blood basophils can be exposed to virions or HIV products during infection. Several HIV proteins (i.e., envelope glycoproteins gp120 and gp41, Tat, and Nef) can interact with distinct surface receptors expressed by human basophils and mast cells and modulate their functional responses at different levels. Additionally, several groups have provided evidence that human mast cells can be infected in vitro, as well as in vivo, by certain strains of HIV. Recently, it has been demonstrated that basophils purified from healthy donors and intestinal mast cells can efficiently capture HIV on their cell surface and, cocultured with CD4⁺ T cells, they can transfer the virus to the cocultured cells leading to infection. Direct contact between human basophils or intestinal mast cells and CD4⁺ T cells can mediate viral trans-infection of T cells through the formation of viral synapses. Thus, basophils and mast cells can provide a cellular basis for capturing and then spreading viruses throughout the body. Collectively, these findings suggest that human basophils and mast cells play a complex and possibly distinct role in HIV infection, warranting further investigations.

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The Mast Cell in Innate and Adaptive Immunity

Shelburne

Abraham

2011

Mast Cell Biology

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Mast cells (MCs) were once considered only as effector cells in pathogenic IgE- and IgG-mediated responses such as allergy. However, developments over the last 15 years have suggested that MCs have evolved in vertebrates as beneficial effector cells that are involved in the very first inflammatory responses generated during infection. This pro-inflammatory environment has been demonstrated to be important for initiating innate responses in many different models of infection and more recently, in the development of adaptive immunity as well. Interestingly this latter finding has led to the discovery that small MC-activating compounds can behave as adjuvants in vaccine formulations. Thus, our continued understanding of the MC in the context of infectious disease is likely to not only expand our scope of the MC in the normal processes of immunity, but provide new therapeutic targets to combat disease.

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Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4

Cited by 19 publications

References 56 publications

Are mast cells the Trojan horse in HIV-1 infection?

Are mast cells the Trojan horse in HIV-1 infection?

Are Basophils and Mast Cells Masters in HIV Infection?

The Mast Cell in Innate and Adaptive Immunity

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