Alterations in Low-Level Perceptual Networks Related to Clinical Severity in PTSD after an Earthquake: A Resting-State fMRI Study

Shang, Jing; Lui, Su; Meng, Yajing; Zhu, Hongru; Qiu, Changjian; Gong, Qiyong; Liao, Wei; Zhang, Wei

doi:10.1371/journal.pone.0096834

Cited by 78 publications

(79 citation statements)

References 65 publications

(78 reference statements)

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“…The SMN has been found related to motor skill learning in animal and human motor control studies ; motor skill learning is accompanied by changes in the connectivity between the SMN and other brain networks associated with the motor function . Consistent with previous studies, Shang et al found a changed spontaneous FC in the SMN using independent component analysis. Whalley et al also suggested that flashbacks in PTSD are correlated with activation in the motor areas, which suggests that flashbacks are a form of memory facilitating action on the environment (e.g., fight‐or‐flight response).…”

Section: Discussionsupporting

confidence: 64%

“…Whalley et al also suggested that flashbacks in PTSD are correlated with activation in the motor areas, which suggests that flashbacks are a form of memory facilitating action on the environment (e.g., fight‐or‐flight response). The increased FC of the motor cortex has also been suggested to represent a brain correlate of preparation for reacting with a physical threat , which is compatible with the psychobiological foundation underlying PTSD . However, LIM regions including the orbitofrontal cortex (OFC) and temporal pole have been widely reported in studies of PTSD and are involved in the reappraisal of emotional processing.…”

Section: Discussionmentioning

confidence: 96%

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Multivariate classification of earthquake survivors with post‐traumatic stress disorder based on large‐scale brain networks

Zhu

Yuan

Qiu

et al. 2020

Acta Psychiatr Scand

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Objective The identification of post‐traumatic stress disorder (PTSD) among natural disaster survivors is remarkably challenging, and there are no reliable objective signatures that can be used to assist clinical diagnosis and optimize treatment. The current study aimed to establish a neurobiological signature of PTSD from the connectivity of large‐scale brain networks and clarify the brain network mechanisms of PTSD. Methods We examined fifty‐seven unmedicated survivors with chronic PTSD and 59 matched trauma‐exposed healthy controls (TEHCs) using resting‐state functional magnetic resonance imaging (rs‐fMRI). We extracted the node‐to‐network connectivity and obtained a feature vector with a dimensionality of 864 (108 nodes × 8 networks) to represent each subject’s functional connectivity (FC) profile. Multivariate pattern analysis with a relevance vector machine was then used to distinguish PTSD patients from TEHCs. Results We achieved a promising diagnostic accuracy of 89.2% in distinguishing PTSD patients from TEHCs. The most heavily weighted connections for PTSD classification were among the default mode network (DMN), visual network (VIS), somatomotor network, limbic network, and dorsal attention network (DAN). The strength of the anticorrelation of FC between the ventral medial prefrontal cortex (vMPFC) in DMN and the VIS and DAN was associated with the severity of PTSD. Conclusions This study achieved relatively high accuracy in classifying PTSD patients vs. TEHCs at the individual level. This performance demonstrates that rs‐fMRI‐derived multivariate classification based on large‐scale brain networks can provide potential signatures both to facilitate clinical diagnosis and to clarify the underlying brain network mechanisms of PTSD caused by natural disasters.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 96%

Multivariate classification of earthquake survivors with post‐traumatic stress disorder based on large‐scale brain networks

Zhu

Yuan

Qiu

et al. 2020

Acta Psychiatr Scand

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“…Not significant in the analysis without the studies of (Zhong and co‐workers) and (Shang and co‐workers), which used ReHo and ICA, respectively. Instead, the culmen of the cerebellum became significant (MNI xyz coordinates = 30, −54, −18, cluster volume = 152 mm 3 ).…”

Section: Resultsmentioning

confidence: 92%

Aberrant Resting-State Brain Activity in Posttraumatic Stress Disorder: A Meta-Analysis and Systematic Review

et al. 2016

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Combined, these altered resting-state connectivity and activity patterns could represent neurobiological correlates of increased salience processing and hypervigilance (SN), at the cost of awareness of internal thoughts and autobiographical memory (DMN) in PTSD. However, several discrepancies between findings of the meta-analysis and systematic review were observed, stressing the need for future studies on resting-state abnormalities in PTSD patients.

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“…Remarkably, calligraphy therapy was also effective in reducing hyperarousal symptoms among child survivors in Wenchuan earthquake (Z. Zhu et al, 2014). …”

Section: Chinese Medicinementioning

confidence: 99%

Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake

Hong

Efferth

2016

Trauma, Violence, & Abuse

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Post-traumatic stress disorder (PTSD) widely occurs among victims or witness of disasters. With flashbacks, hyperarousal, and avoidance being the typical symptoms, PTSD became a focus of psychological research. The earthquake in Wenchuan, China, on May 12, 2008, was without precedent in magnitude and aftermath and caused huge damage, which drew scientists' attention to mental health of the survivors. We conducted a systematic overview by collecting published articles from the PubMed database and classifying them into five points: epidemiology, neuropathology, biochemistry, genetics and epigenetics, and treatment. The large body of research during the past 6 years showed that adolescents and adults were among the most studied populations with high prevalence rates for PTSD. Genomic and transcriptomic studies focusing on gene × environment studies as well as epigenetics are still rare, although a few available data showed great potential to better understand the pathophysiology of PTSD as multifactorial disease. Phytotherapy with Chinese herbs and acupuncture are rarely reported as of yet, although the first published data indicated promising therapy effects. Future studies should focus on the following points: (1) The affected populations under observation should be better defined concerning individual risk factor, time of observation, spatial movement, and individual disease courses of patients. (2) The role of social support for prevalence rates of PTSD should be observed in more detail. (3) Efficacy and safety of Chinese medicine should be studied to find potential interventions and effective treatments of PTSD.

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Alterations in Low-Level Perceptual Networks Related to Clinical Severity in PTSD after an Earthquake: A Resting-State fMRI Study

Cited by 78 publications

References 65 publications

Multivariate classification of earthquake survivors with post‐traumatic stress disorder based on large‐scale brain networks

Multivariate classification of earthquake survivors with post‐traumatic stress disorder based on large‐scale brain networks

Aberrant Resting-State Brain Activity in Posttraumatic Stress Disorder: A Meta-Analysis and Systematic Review

Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake

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