Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia

Abstract

The present study was intended to appraise the oxidant and antioxidant status in preeclampsia women. Seventy-seven preeclampsia women with severe variety having average B.P. of 170/140 mmHg with proteinuria; 47 preeclampsia women with mild variety having average B.P. of 138/100 mmHg were compared to 56 healthy pregnant women and 15 non-pregnant women for oxidant and antioxidant status. Lipid peroxidation was assessed by measuring malondialdehyde (MDA), and antioxidant status was assessed by measuring antioxidant enzymes N.B.; superoxide dismutase (SOD), glutathione peroxidase, catalase and vitamins viz; A, E, C and reduced glutathione (GSH). Lipid peroxidation was significantly higher in severe preeclampsia women. Antioxidant status was also compromised as is evident from decreased GSH levels and increased SOD activities not only in severe preeclampsia but also in normal pregnancy and mild preeclampsia women compared to non-pregnant women. Decreased antioxidant enzyme activity viz catalase and glutathione peroxidase was observed in pregnancy as compared to non-pregnant women. The levels of vitamin E which act as an antioxidant were significantly elevated in preeclampsia compared to that of normal pregnancy. These findings conclude that initially the oxidative stress due to pregnancy-induced hypertension is critically combated by the intricate defensive mechanism of natural antioxidant system of the body. It appears that this imbalance between oxidant and antioxidant is the effect of disease and not the causative factor.

Effect of Serum Trace Elements, Macro-minerals and Antioxidants in Acne Vulgaris Patients: A Case-Control Study

“…33 Moreover, antioxidants also prevent lipid peroxidation by free radical inactivation. 34 Our study showed a significantly lower level of vitamin A (p = 0.02) in acne patients in comparison with controls, but the difference between vitamin E was not significant. According to an earlier study, retinoids (a chemical form of vitamin A) was used to treat acne vulgaris which suggests that vitamin A deficiency can be a causative factor of this disease which we found in our study as well.…”

Evaluation of Oxidative Stress and Antioxidant Defence in Subjects of Preeclampsia

“…Their elevation may be an adaptive response to counter the effect of increased oxidative stress. Reduced glutathione was found to be decreased in preeclamptic females in studies at Turkey and study by Kaur G et al [10] in India. The latter study also showed significant elevation in Vitamin E levels as compared to normal pregnancy.…”

Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

“…15 The present study found that catalase was significantly lower in the PE group than in the HP and NP groups, an observation compatible with the results of previous investigations. 29,30 Antioxidant nutrient levels can be manipulated simply by dietary or pharmacological supplements. 9 The importance of vitamin E and β-carotene in preventing free radical damage is well known and their levels have been reported to be significantly decreased in pre-eclampsia.…”