Alterations in lipid metabolism induced by recombinant bovine tumor necrosis factor-alpha administration to dairy heifers

Kushibiki, Shiro; Hodate, Koichi; Shingu, H.; Hayashi, Takio; Touno, Eiko; Shinoda, Mitsuru; Yokomizo, Yuichi

doi:10.2527/2002.8082151x

Cited by 34 publications

(37 citation statements)

References 27 publications

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“…4A), but the increase was significantly greater throughout the experiment in fattyliver cows. Recent investigations show that administration of TNF-α to experimental animals is associated with decreased appetite and cachexia (von Haehling et al 2002) and increased release of NEFA from adipose tissue into plasma (Kushibiki et al 2002). The BCS of our fatty-liver cows declined immediately after parturition, and their DMI was numerically lower than that of controls during the experiment.…”

Section: Discussionmentioning

confidence: 99%

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Ametaj¹,

Bradford²,

Bobe³

et al. 2005

Can. J. Anim. Sci.

156

126

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. 2005. Strong relationships between mediators of the acute phase response and fatty liver in dairy cows. Can. J. Anim. Sci. 85: [165][166][167][168][169][170][171][172][173][174][175]. The objective of this study was to investigate the relationship between activation of acute phase response and fatty liver in transition dairy cows. Fatty liver was induced in dairy cows by feeding 8 kg of cracked corn 1 mo before the expected day of parturition. Liver and blood samples were obtained at days -4, 3, 8, 12, 14, 22, 27, and 36 postpartum. Cows that developed fatty liver (n = 4) reached peak total lipids in the liver at day 12 postpartum with 11.4% (wet wt.) compared with 6.6% in control cows (n = 4). Cows with fatty liver had greater plasma tumor necrosis factor-alpha (TNF-α), nonesterified fatty acids (NEFA), and lower lactate concentrations than did control cows at day -4. During highest concentrations of total lipids in the liver, for at least one time-point, fatty-liver cows had greater concentrations of plasma serum amyloid A (SAA), haptoglobin, and NEFA and lower concentrations of calcitonin gene-related peptide (CGRP), prostaglandin E 2 (PGE 2 ), cortisol, and TNF-α than did control cows. Concentrations of total lipids in the liver at 12 d postpartum were correlated (a) positively with plasma TNF-α, SAA, and NEFA and negatively with plasma CGRP before calving, (b) positively with plasma SAA, haptoglobin, and NEFA and negatively with plasma PGE 2 , CGRP, total cholesterol, and glucose at days 3, 8, and 12 postpartum, and (c) negatively with concentrations of plasma glucose, lactate, and total bilirubin after day 12 postpartum. In conclusion, this study indicates that the acute phase response occurs in cows with fatty liver as well as strong relationships between mediators of immune response and fatty liver. Mots clés: Réponse phase aiguë, foie gras, vaches laitièresFatty liver is a common metabolic disorder that affects almost half of all dairy cows immediately after parturition.Despite much progress in understanding metabolic events during the development of fatty liver, the precise mechanisms of the pathology remain unclear. The conventional view is that fatty liver is characterized by excess liver triacylglycerols (TAG) arising from a negative energy balance after parturition (Bauchart et al. 1998). The negative energy balance evokes a major mobilization of non-esterified fatty acids (NEFA) from adipose tissue and increased uptake of

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Section: Discussionmentioning

confidence: 99%

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Ametaj¹,

Bradford²,

Bobe³

et al. 2005

Can. J. Anim. Sci.

156

126

View full text Add to dashboard Cite

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“…Moreover, both investigated APPs correlated positively with non-esterified fatty acids. Recent investigations show that administration of TNFα to experimental animals is associated with decreased appetite and cachexia, and increased release of NEFA from adipose tissue into plasma (Kushibiki et al 2002). Therefore, a higher concentration of NEFA in serum could be related to activation of the immune system.…”

Section: Kinetic Variables Ofmentioning

confidence: 99%

Acute Phase Proteins and their Relation to Energy Metabolites in Dairy Cows during the Pre- and Postpartal Period

et al. 2009

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The objective of this study was to evaluate the concentrations of selected acute phase proteins -haptoglobin (Hp) and serum amyloid A (SAA), and selected variables of energy metabolism in blood serum of dairy cows during different stages of the pre-and postpartal period. The analyses were performed in dairy cows of the Slovak spotted breed and its crossbreeds (n = 57). The cows were divided into 9 groups according to the evaluated part of reproduction cycle -from 4 weeks before parturition to 10 weeks after parturition. Significant differences were found in mean Hp and SAA concentrations during the monitored period (P < 0.05 and P < 0.001, respectively). Cows during the early postparturient period had significantly higher Hp and SAA concentrations compared to cows in later postparturient period (P < 0.05). Significant differences throughout the period under study was found also in means of total cholesterol (P < 0.01), triglycerides (P < 0.001), and non-esterified fatty acids (P < 0.001). Concentrations of Hp during this period were positively correlated with SAA (R = 0.919; P < 0.001). Moreover, significant correlations were found between Hp and non-esterified fatty acids, Hp and β-hydroxybutyrate, as well as between SAA and non-esterified fatty acids. Our results indicate that the acute phase response occurs in cows around parturition, and suggest that there are relationships between mediators of immune response and several indices of energy metabolism. Our results also suggest that in cows with higher concentrations of non-esterified fatty acids, indicating a certain degree of lipid mobilisation, higher values of acute phase proteins may be found. Haptoglobin, serum amyloid A, energy balance, cows, periparturient period

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“…Our study showed highly positive correlation between the concentrations of Hp and SAA, as well as between both measured acute phase proteins and the concentrations of NEFA in dairy cows after calving. Kushibiki et al (2002) stated that administration of tumor necrosis factor to dairy cattle, promotes the production of acute phase proteins and is associated with decreased appetite and cachexia, and increased release of NEFA from adipose tissue into the plasma. Therefore, higher concentrations of nonesterified fatty acids in serum could be related to the activation of the immune system.…”

Section: Relationships Between Acute Phase Proteins and Altered Energmentioning

confidence: 99%

Acute Phase Proteins in Dairy Cows and Sows During the Periparturient Period

Kováč¹,

Tóthová²,

Nagy³

et al. 2011

Acute Phase Proteins as Early Non-Specific Biomarkers of Human and Veterinary Diseases

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Alterations in lipid metabolism induced by recombinant bovine tumor necrosis factor-alpha administration to dairy heifers

Cited by 34 publications

References 27 publications

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Acute Phase Proteins and their Relation to Energy Metabolites in Dairy Cows during the Pre- and Postpartal Period

Acute Phase Proteins in Dairy Cows and Sows During the Periparturient Period

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