Alterations in levels of 8-Oxo-2'-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression

Ceylan, Deniz; Yılmaz, Selda; Tuna, Gamze; Kant, Melis; Er, Ayşe; Ildız, Ayşegül; Verim, Burcu; Akış, Merve; Akan, Pınar; İşlekel, Hüray; Veldić, Marin; Frye, Mark A.; Özerdem, Ayşegül

doi:10.1016/j.psyneuen.2020.104600

Cited by 26 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies report an association between oxidative stress and distress-related psychiatric diseases, such as depression, anxiety and PTSD [144][145][146][147][148][149][150][151][152][153][154][155][156]. One meta-analysis demonstrated that oxidative stress, as measured by 8-OHdG and F2-isoprostanes, is increased in depression [144].…”

Section: Oxidative Stressmentioning

confidence: 99%

See 1 more Smart Citation

Telomere Shortening and Psychiatric Disorders: A Systematic Review

Pousa

Souza

Melo

et al. 2021

Cells

View full text Add to dashboard Cite

Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact on our physiology and aging than it was previously thought. A systematic search of the literature using MeSH descriptors of psychological distress (“Traumatic Stress Disorder” or “Anxiety Disorder” or “depression”) and telomere length (“cellular senescence”, “oxidative stress” and “telomere”) was conducted on PubMed, Cochrane Library and ScienceDirect databases. A total of 56 studies (113,699 patients) measured the TL from individuals diagnosed with anxiety, depression and posttraumatic disorders and compared them with those from healthy subjects. Overall, TL negatively associates with distress-related mental disorders. The possible underlying molecular mechanisms that underly psychiatric diseases to telomere shortening include oxidative stress, inflammation and mitochondrial dysfunction linking. It is still unclear whether psychological distress is either a cause or a consequence of telomere shortening.

show abstract

Section: Oxidative Stressmentioning

confidence: 99%

“…Such alterations are reversed upon resolution of the depressive state [144,145]. PTSD patients have different concentrations of blood antioxidant enzymes as compared to healthy controls [146].…”

Section: Oxidative Stressmentioning

confidence: 99%

Telomere Shortening and Psychiatric Disorders: A Systematic Review

Pousa

Souza

Melo

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…In patients with depression, increased concentrations of oxidative damage markers were detected, including 8-oxoguanine, a product of guanine oxidation, as well as malondialdehyde, a compound formed in the process of lipid peroxidation [95]. Induced by oxidative stress, the Ogg1 gene is expressed in the brain and can be a cellular marker for oxidative DNA damage [96,97]. The current study revealed a significant decrease in the mRNA level of Ogg1 in the prefrontal cortex of mice receiving istradefylline or DPCPX with Zn 2+ in comparison to the control group, which may indicate potential benefits in terms of antioxidant capacity.…”

Section: Gene Expression Analysismentioning

confidence: 99%

The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies

Szopa

Bogatko

Herbet

et al. 2021

IJMS

View full text Add to dashboard Cite

The purpose of the study was to investigate whether the co-administration of Mg2+ and Zn2+ with selective A1 and A2A receptor antagonists might be an interesting antidepressant strategy. Forced swim, tail suspension, and spontaneous locomotor motility tests in mice were performed. Further, biochemical and molecular studies were conducted. The obtained results indicate the interaction of DPCPX and istradefylline with Mg2+ and Zn2+ manifested in an antidepressant-like effect. The reduction of the BDNF serum level after co-administration of DPCPX and istradefylline with Mg2+ and Zn2+ was noted. Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression. Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone. It seems plausible that a combination of selective A1 as well as an A2A receptor antagonist and magnesium or zinc may be a new antidepressant therapeutic strategy.

show abstract

“…OGG1 expression in the blood has been investigated in various human studies with various pathologies. Down-regulation has been observed in patients with unipolar and bipolar disorder [29,30], Alzheimer's' disease [31] and primary open-angle glaucoma [32] compared to in controls. Moreover, our study revealed that OGG1 expression was lower in the smokers than in the non-smokers, only in the controls (Table S3).…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of Redox Status in Urinary Bladder Cancer Patients

Reszka

Lesicka

Wieczorek

et al. 2020

Cancers

View full text Add to dashboard Cite

The alteration of redox homeostasis constitutes an important etiological feature of common human malignancies. We investigated DNA damage, selenium (Se) levels and the expression of cytoprotective genes involved in (1) the KEAP1/NRF2/ARE pathway, (2) selenoprotein synthesis, and (3) DNA methylation and histone deacetylation as putative key players in redox status dysregulation in the blood of urinary bladder cancer (UBC) patients. The study involved 122 patients and 115 control individuals. The majority of patients presented Ta and T1 stages. UBC recurrence occurred within 0.13 to 29.02 months. DNA damage and oxidative DNA damage were significantly higher in the patients compared to the controls, while plasma Se levels were significantly reduced in the cases compared to the controls. Of the 25 investigated genes, elevated expression in the peripheral blood leukocytes in patients was observed for NRF2, GCLC, MMP9 and SEP15, while down-regulation was found for KEAP1, GSR, HMOX1, NQO1, OGG1, SEPW1, DNMT1, DNMT3A and SIRT1. After Bonferroni correction, an association was found with KEAP1, OGG1, SEPW1 and DNMT1. Early recurrence was associated with the down-regulation of PRDX1 and SRXN1 at the time of diagnosis. Peripheral redox status is significantly dysregulated in the blood of UBC patients. DNA strand breaks and PRDX1 and SRXN1 expression may provide significant predictors of UBC recurrence.

show abstract

Alterations in levels of 8-Oxo-2'-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression

Cited by 26 publications

References 45 publications

Telomere Shortening and Psychiatric Disorders: A Systematic Review

Telomere Shortening and Psychiatric Disorders: A Systematic Review

The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies

Dysregulation of Redox Status in Urinary Bladder Cancer Patients

Contact Info

Product

Resources

About