Alterations in hepatic metabolism of sulfur amino acids in non-obese type-2 diabetic Goto-Kakizaki rats

Jung, Young Suk; Yun, Kang Uk; Ryu, Chang Seon; Oh, Jung Min; Kwak, Hui Chan; Lee, Ji-Yoon; Park, Song-Kyu; Kim, Bong Hee; Oh, Soo Jin; Kim, Sang Kyum

doi:10.1016/j.cbi.2013.04.014

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…Plasma total homocysteine concentration increased by 1.6-fold in obese mice fed a high-fat diet for 12 weeks [7], but was 40% lower in db/ db mice, obese type 2 diabetic animals with a G-to-T point mutation of the leptin receptor [6]. In contrast, plasma homocysteine levels were similar between control rats and non-obese type diabetic Goto-Kakizaki rats [8]. Interestingly, db/db mice exhibited decreases in hepatic and plasma sulfur amino acids and their metabolites, including methionine, homocysteine, cysteine, Sadenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and hypotaurine.…”

Section: Introductioncontrasting

confidence: 65%

“…In our previous study, non-obese type 2 diabetic Goto-Kakizaki rats exhibited the increased hepatic methionine, cysteine, GSH, hypotaurine and taurine levels and the decreased hepatic SAM levels [8]. Homocysteine levels in liver and plasma were comparable between normal and Goto-Kakizaki rats.…”

Section: Discussionmentioning

confidence: 94%

“…An HPLC method was used to determine the hepatic SAM and SAH concentration [8]. The supernatant obtained after 10% PCA treatment was applied to an HPLC system (Shimadzu, SCL-10A) equipped with an ultraviolet detector (Shimadzu, SPD-10Avp, 254 nm) and a TSK-GEL ODS-80TM column (4.6 mm Â 250 mm, 5 mm; Tosoh Co., Tokyo, Japan).…”

Section: Determination Of Sulfur Amino Acids and Their Metabolites Inmentioning

confidence: 99%

“…Our previous studies showed that changes in plasma homocysteine level in obese or diabetic conditions were dependent on the type of experimental animal model used [6][7][8]. Plasma total homocysteine concentration increased by 1.6-fold in obese mice fed a high-fat diet for 12 weeks [7], but was 40% lower in db/ db mice, obese type 2 diabetic animals with a G-to-T point mutation of the leptin receptor [6].…”

Section: Introductionmentioning

confidence: 97%

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Sulfur amino acid metabolism in Zucker diabetic fatty rats

Kwak

Kim

et al. 2015

Biochemical Pharmacology

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Section: Introductioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 94%

Section: Determination Of Sulfur Amino Acids and Their Metabolites Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Sulfur amino acid metabolism in Zucker diabetic fatty rats

Kwak

Kim

et al. 2015

Biochemical Pharmacology

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“…S-adenosylmethionine (SAMe) is an over-the-counter (OTC) dietary supplement and is sought for its ability to increase levels of the antioxidant glutathione [ 11 ]. SAMe is decreased in the livers of non-obese type 2 diabetic Goto-Kakizaki rats [ 12 ], db/db mice [ 13 ], and mice fed a high-fat diet [ 14 ]. Inclusion of SAMe into a diet attenuated sucrose-facilitated meal-induced insulin sensitization, an indicator of diabetic development, possibly due to its ability to increase glutathione in the liver [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Obesity Prevents S-Adenosylmethionine-Mediated Improvements in Age-Related Peripheral and Hippocampal Outcomes

Velden

Osborne

2021

Nutrients

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Background: Age predisposes individuals to a myriad of disorders involving inflammation; this includes stress-related neuropsychiatric disorders such as depression and anxiety, and neurodegenerative diseases. Obesity can further exacerbate these effects in the brain. We investigated whether an inexpensive dietary supplement, s-adenosylmethionine (SAMe), could improve age- and/or obesity-related inflammatory and affective measures in the hippocampus. Methods: Mice were placed on their diets at six weeks of age and then aged to 14 months, receiving SAMe (0.1 g/kg of food) for the final six weeks of the experiment. Prior to tissue collection, mice were tested for anxiety-like behaviors in the open field test and for metabolic outcomes related to type 2 diabetes. Results: SAMe treatment significantly improved outcomes in aged control mice, where fasting glucose decreased, liver glutathione levels increased, and hippocampal microglia morphology improved. SAMe increased transforming growth factor β-1 mRNA in both control mice, potentially accounting for improved microglial outcomes. Obese mice demonstrated increased anxiety-like behavior, where SAMe improved some, but not all, open field measures. Conclusions: In summary, SAMe boosted antioxidant levels, improved diabetic measures, and hippocampal inflammatory and behavioral outcomes in aged mice. The effects of SAMe in obese mice were more subdued, but it could still provide some positive outcomes for obese individuals dealing with anxiety and having difficulty changing their behaviors to improve health outcomes.

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Difference in the metabolome of colostrum from healthy mothers and mothers with type 2 diabetic mellitus

Han

Sun

et al. 2021

Eur Food Res Technol

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Alterations in hepatic metabolism of sulfur amino acids in non-obese type-2 diabetic Goto-Kakizaki rats

Cited by 8 publications

References 42 publications

Sulfur amino acid metabolism in Zucker diabetic fatty rats

Sulfur amino acid metabolism in Zucker diabetic fatty rats

Obesity Prevents S-Adenosylmethionine-Mediated Improvements in Age-Related Peripheral and Hippocampal Outcomes

Difference in the metabolome of colostrum from healthy mothers and mothers with type 2 diabetic mellitus

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