Alterations in episodic memory in patients with systemic lupus erythematosus☆

Coín-Mejías, M. Angeles; Peralta-Ramírez, María Isabel; Santiago‐Ramajo, Sandra; Morente-Soto, Gustavo; Ortego-Centeno, Norbérto; Rubio, José-Luis Callejas; Jiménez-Alonso, J; Gómez-Ríos, Manuel; Pérez-Garcı́a, Miguel

doi:10.1016/j.acn.2007.11.001

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Memory impairment is also commonly reported in SLE. 43,44 but in our study, recall of both verbal and non-verbal information was only impaired in few patients. Some authors have explained that the general deficiency in memory may be the result of attention problems rather than memory problems per se.…”

Section: Discussioncontrasting

confidence: 73%

Do subjective cognitive complaints correlate with cognitive impairment in systemic lupus erythematosus? A Danish outpatient study

Vogel

Bhattacharya

Larsen

et al. 2011

Lupus

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This study examined the prevalence of cognitive impairment and its association with depressive symptoms and self-reported cognitive complaints in Danish outpatients with systemic lupus erythematosus (SLE). Fifty-seven consecutive female SLE-outpatients were examined with a comprehensive neuropsychological test-battery, a 20-item self-administered Perceived Deficits Questionnaire (PDQ) and a self-rated depression scale (Major Depression Inventory). Twenty-two patients (38.5%) were classified as cognitively impaired, mostly with deficits in executive functions and attention. Among cognitively impaired patients only 18.2% had significantly higher PDQ scores than the normal range. PDQ scores were highly correlated to depressive symptoms (r = 0.67, p < 0.001). Only two neuropsychological tests were significantly correlated with subjective cognitive complaints. When these variables and self-rated depression score were entered into a regression model both depression score and Symbol Digit Modalities Test performances were significantly associated with the PDQ score. In conclusion, cognitive impairments were common in this group of (mild) SLE outpatients, but the level of significant subjective cognitive complaints was low even among patients with cognitive impairment. Affective status may influence subjective experience of cognitive functions even more than cognitive functioning itself, and absence of subjective cognitive complaints did not exclude the presence of cognitive impairments.

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Section: Discussioncontrasting

confidence: 73%

Do subjective cognitive complaints correlate with cognitive impairment in systemic lupus erythematosus? A Danish outpatient study

Vogel

Bhattacharya

Larsen

et al. 2011

Lupus

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“…The ability to study cognitive function in non–English speakers is limited. In a recent study, a word memory test for SLE patients was successfully adapted to Spanish (106).…”

Section: Cognitive Assessment Of Patients With Slementioning

confidence: 99%

Mammary serine protease inhibitor inhibits epithelial growth factor‐induced epithelial‐mesenchymal transition of esophageal carcinoma cells

Zhang¹,

Zhou²,

Lei³

et al. 2008

Cancer

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BACKGROUND:By using proteomic technology, the authors previously observed the substantial down‐regulation of mammary serine protease inhibitor (maspin) in esophageal squamous cell carcinoma and metastases. In the current study, they examined the effects of maspin re‐expression in a maspin‐null esophageal cancer cell line EC109 and also investigated the underlying mechanism.METHODS:A cell line with stable maspin expression was established. An epithelial growth factor (EGF)‐induced epithelial‐mesenchymal transition (EMT) model was used to mimic some aspects of the metastatic process in vitro. The effects of maspin reintroduction on EGF‐induced EMT and cell growth characteristics were evaluated. Comparative proteomic analysis of transfected cells versus parental cells was then performed to explore the potential mechanism.RESULTS:The introduction of maspin into EC109 cells was able to inhibit EGF‐induced EMT and altered cell growth characteristics, including the serum dependence, proliferative response to EGF stimulation, and colony formation ability in soft agar, indicating a conversion from a malignant phenotype to a benign phenotype. Proteomic analysis revealed a significant down‐regulation of a group of glycolytic enzymes in maspin‐transfected cells. In addition, maspin‐transfected cells expressed much lower levels of hypoxia‐inducible factor 1α than parental cells or empty vector transfected cells.CONCLUSIONS:Maspin exhibited a metastasis‐suppressive effect, which may be a consequence of the reversal of the malignant phenotype of EC109 cells. The switch of cellular metabolic phenotype to low glycolysis by the gain of maspin function may play a key role in the process. This finding provides additional evidence of the tumor metastasis‐suppressive activity of maspin and may indicate a new direction for future studies of the mechanism of maspin. Cancer 2009. © 2008 American Cancer Society.

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“…Difficulties with the acquisition and maintenance of newly acquired information is a common subjective complaint amongst patients with SLE, and objective deficits in the acquisition and recall of new verbal information 18,30–32 as well as of visual memory 18,30,31 is well supported.…”

Section: Introductionmentioning

confidence: 99%

Cognitive functioning in systemic lupus erythematosus: a meta-analysis

Leslie

Crowe

2018

Lupus

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Cognitive deficits are common in patients with systemic lupus erythematosus (SLE) regardless of overt neuropsychiatric involvement; however, a clear neuropsychological profile of SLE has not emerged. This study undertook a literature search of the PubMed, Scopus and Ovid (PsychINFO) databases for studies investigating cognitive alterations in SLE, using standardized neuropsychological (NP) measures. The data were analysed using meta-analytical procedures. The results support the observation that relative to healthy controls, SLE (regardless of overt neuropsychiatric involvement) is associated with statistically significant, small effect-sized deficits in visual attention, cognitive fluency, immediate visual memory and visual reasoning. Moreover, the results support a gradient of cognitive disturbance in SLE with significantly greater cognitive impairment in NPSLE patients relative to non-NPSLE patients. Medium-sized deficits were observed in NPSLE patients relative to healthy controls across the domains of: complex attention, delayed verbal memory, language and verbal reasoning (with small or non-significant differences observed in non-NPSLE patients relative to healthy controls). These results are relevant to the understanding, assessment and rehabilitation of patients living with SLE, with or without overt neuropsychiatric involvement.

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Alterations in episodic memory in patients with systemic lupus erythematosus☆

Cited by 3 publications

References 36 publications

Do subjective cognitive complaints correlate with cognitive impairment in systemic lupus erythematosus? A Danish outpatient study

Do subjective cognitive complaints correlate with cognitive impairment in systemic lupus erythematosus? A Danish outpatient study

Mammary serine protease inhibitor inhibits epithelial growth factor‐induced epithelial‐mesenchymal transition of esophageal carcinoma cells

Cognitive functioning in systemic lupus erythematosus: a meta-analysis

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