Alterations in emotion generation and regulation neurocircuitry in depression and eating disorders: A comparative review of structural and functional neuroimaging studies

Donofry, Shannon D.; Roecklein, Kathryn A.; Wildes, Jennifer E.; Miller, Megan M.; Erickson, Kirk I.

doi:10.1016/j.neubiorev.2016.07.011

Cited by 43 publications

(32 citation statements)

References 149 publications

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“…Eating disorders have been shown to be associated with both the MetS [ 39 ] and mindfulness [ 40 ]. Individuals suffering from eating disorders have defects in emotion processing [ 41 ] and mindfulness which might contribute to regulating emotions [ 42 ]. In addition, eating disorders have been associated with cognitive rumination [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Mindfulness Is Associated with the Metabolic Syndrome among Individuals with a Depressive Symptomatology

et al. 2018

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The Metabolic Syndrome (MetS) is a major public health burden. Dispositional mindfulness has recently been associated with eating disorders, being overweight, and could therefore be associated with the MetS. We aimed to examine in a cross-sectional design the relationship between mindfulness, the MetS, and its risk factors in a large sample of the adult general population and the influence of depressive symptomatology on this association. Adults participating in the NutriNet-Santé study who had completed the Five Facets Mindfulness Questionnaire and attended a clinical and biological examination were available for inclusion. Multivariable logistic regression models adjusted for socio-demographic and lifestyle factors were performed. A total of 17,490 individuals were included. Among individuals with a depressive symptomatology, those with higher mindfulness were less likely to have a MetS (OR: 0.73, 95% CI: 0.57–0.93), a high waist circumference, a low HDL-cholesterol level and an elevated fasting blood glucose level (all p <0.05). In those without depressive symptomatology, individuals with higher mindfulness were less likely to have a high waist circumference (p <0.01). In conclusion, higher mindfulness was associated with lower odds of developing a MetS only among individuals with a depressive symptomatology.

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Section: Discussionmentioning

confidence: 99%

Mindfulness Is Associated with the Metabolic Syndrome among Individuals with a Depressive Symptomatology

et al. 2018

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“…Moreover, morphological results have shown the volume of the amygdala in obesity is larger than that in individuals with normal weight (33). Changes in amygdala function and morphology overlap to a large extent in depression and eating disorders, which illustrates the necessary role of the amygdala in managing emotional and eating behaviors (34). The hippocampus is involved in learning/memory processes and it plays a crucial role in regulating food intake.…”

Section: Original Articlementioning

confidence: 99%

Abnormal Regional Neural Activity and Reorganized Neural Network in Obesity: Evidence from Resting‐State fMRI

Zhang

et al. 2020

Obesity

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This study aimed to investigate regional neural activity and regulation of patterns in the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior. Methods: A total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI) data were acquired using 3.0-T MRI. Amplitude of low-frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Processing Assistant for resting-state fMRI and Resting-State fMRI Data Analysis Toolkit (REST). Results: The group with obesity showed increased amplitude of low-frequency values in left fusiform gyrus/amygdala, inferior temporal gyrus (ITG), hippocampus/parahippocampal gyrus, and bilateral caudate but decreased values in right superior temporal gyrus. The group with obesity showed increased FC between left caudate and right superior temporal gyrus, left fusiform gyrus/amygdala and left ITG, right caudate and left fusiform gyrus/amygdala, and right caudate and left hippocampus/parahippocampal gyrus. Dutch Eating Behavior Questionnaire-Emotional scores were positively correlated with FC between left hippocampus/parahippocampal gyrus and right caudate but negatively correlated with FC between left fusiform gyrus/amygdala and left ITG. Conclusions: The study indicated the reorganized neural network presented as a bilateral cross-regulation pattern across hemispheres between reward and various appetite-related functional processing, thus affecting emotional and external eating behavior. These results could provide further evidence for neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential in obesity.

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“…Given the magnitude of this public health issue, it is imperative to identify risk factors and underlying mechanisms to inform preventive and therapeutic interventions (Farb et al, 2014 ). One potential mechanism in the development and maintenance of depression is difficulties with emotion regulation (Donofry et al, 2016 ). Individuals prone to depression may use maladaptive emotion regulation strategies, where attempts to manage aversive experiences backfire and actually maintain or increase symptoms.…”

Section: Introductionmentioning

confidence: 99%

Emotion Regulation in Current and Remitted Depression: A Systematic Review and Meta-Analysis

et al. 2018

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Background: Major Depressive Disorder (MDD) is a highly prevalent, recurrent, and potentially chronic disorder. Identifying risk factors and underlying mechanisms to inform preventive and therapeutic interventions is therefore imperative. Emotion regulation is a proposed factor in the development and maintenance of MDD. The aim of the present review was to summarize and synthesize research on self-reported emotion regulation strategy use and emotion regulation abilities in adults diagnosed with current and remitted MDD.Methods: Seventy-two eligible studies were retrieved from databases through a systematic literature search. Group differences between individuals with current MDD, remitted MDD, and healthy controls were calculated using meta-analytic procedures. Meta-regression analyses investigated potential moderator effects on emotion regulation difficulties.Results: Results indicated that individuals with current MDD report higher maladaptive emotion regulation strategy use for avoidance (Hedges' g = 1.3), rumination (g = 2.1), and suppression (g = 1.1) compared to healthy controls. Also, they reported lower adaptive emotion regulation strategy use for acceptance (g = −1.0), problem solving (g = −1.0), and reappraisal (g = −0.7). Individuals with current MDD reported limited general emotion regulation abilities, indicated by higher alexithymia (g = 1.45), lower emotional awareness (g = −0.95), emotional clarity (g = −1.50) and emotional tolerance (g = −1.89). Similar results were found in individuals with remitted MDD for avoidance (g = 1.0), rumination (g = 1.1), suppression (g = 0.6), and general emotion regulation abilities. However, no difference was found between individuals with remitted MDD and healthy controls for adaptive emotion regulation strategies. Meta-regression analyses suggest that age of illness onset, comorbid anxiety and duration of remission influence emotion regulation.Conclusion: The present review and meta-analysis indicates that individuals with current and remitted MDD have difficulties with emotion regulation compared to individuals who have never been depressed. Although depressive symptoms improve, emotion regulation difficulties may continue, and could be a contributing factor to relapse. Our findings inform future research on emotion regulation and psychotherapeutic interventions.

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Alterations in emotion generation and regulation neurocircuitry in depression and eating disorders: A comparative review of structural and functional neuroimaging studies

Cited by 43 publications

References 149 publications

Mindfulness Is Associated with the Metabolic Syndrome among Individuals with a Depressive Symptomatology

Mindfulness Is Associated with the Metabolic Syndrome among Individuals with a Depressive Symptomatology

Abnormal Regional Neural Activity and Reorganized Neural Network in Obesity: Evidence from Resting‐State fMRI

Emotion Regulation in Current and Remitted Depression: A Systematic Review and Meta-Analysis

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