Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation

Eiras, Sonia; Narolska, N.A.; Loon, Ramon B. van; Boontje, Nicky M.; Zaremba, R.; Jiménez, Connie R.; Visser, Frans C.; Stooker, Wim; Velden, Jolanda van der; Stienen, G. J. M.

doi:10.1016/j.yjmcc.2006.06.072

Cited by 47 publications

(44 citation statements)

References 33 publications

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“…Slower force kinetics at maximal activation in the cAF myofibrils are consistent with previously described 8,9,20 cAF induced changes in the motor protein. Of the 2 MHC isoforms expressed in human cardiac muscle MHC-␣ is associated with higher actomyosin ATPase activity and faster cross-bridge kinetics than MHC-␤.…”

Section: Mhc Isoform Expressionsupporting

confidence: 91%

“…Similar effect of cAF on maximal active tension (33% reduction) was recently reported for permeabilized human atrial myocytes, 9 though in that study the difference between cAF and SR maximal tension was not significant. A 75% reduction in twitch tension has been reported in intact atrial trabeculae from cAF patients compared to SR patients.…”

Section: Alterations In Contractile Functionsupporting

confidence: 85%

“…pCa 50 of active tension was significantly increased, whereas the Hill coefficient (n H ) was decreased in cAF myofibrils compared to SR myofibrils. No significant change in Ca 2ϩ sensitivity of tension development has been previously reported for permeabilized human cAF preparations, 8,9 though a significant increase in the Ca 2ϩ sensitivity of ATP consumption under isometric conditions has been found in the same cAF preparations. 8 This latter observation seems consistent with the present results, although a discrepancy between the Ca 2ϩ sensitivity of force and isometric ATPase is difficult to explain.…”

Section: Interventions (High Extracellular [Ca 2ϩmentioning

confidence: 68%

“…The lower content in MHC-␣ in cAF myofibrils confirms the previously reported shift of MHC isoforms from MHC-␣ to MHC-␤ for cAF human atrial myocardium. 8,9,20 …”

Section: Mhc Isoform Expressionmentioning

confidence: 99%

“…Consistent with the present results, a significant reduction in k TR was previously reported in permeabilized human atrial myocytes from cAF patients. 9 Relaxation kinetics, determined by sudden Ca 2ϩ removal from myofibrils, predominantly reflects the apparent rate with which attached crossbridges leave force-generating states. 19 Relaxation rates were slower (25% to 35%) in the cAF myofibrils than in the SR myofibrils implying that both cross-bridge attachment and detachment rates contribute to the slower overall cross-bridge turnover in cAF myofibrils.…”

Section: Alterations In Contractile Functionmentioning

confidence: 99%

See 4 more Smart Citations

Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils

Belus

Piroddi

Ferrantini

et al. 2010

Circulation Research

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Section: Mhc Isoform Expressionsupporting

confidence: 91%

Section: Alterations In Contractile Functionsupporting

confidence: 85%

Section: Interventions (High Extracellular [Ca 2ϩmentioning

confidence: 68%

“…The lower content in MHC-␣ in cAF myofibrils confirms the previously reported shift of MHC isoforms from MHC-␣ to MHC-␤ for cAF human atrial myocardium. 8,9,20 …”

Section: Mhc Isoform Expressionmentioning

confidence: 99%

Section: Alterations In Contractile Functionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils

Belus

Piroddi

Ferrantini

et al. 2010

Circulation Research

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Cardiac Physiology of Aging: Extracellular Considerations

Horn

2015

Comprehensive Physiology

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Aging is a major risk factor for the development of cardiovascular disease, with the majority of affected patients being elderly. Progressive changes to myocardial structure and function occur with aging, often in concert with underlying pathologies. However, whether chronological aging results in a remodeled "aged substrate" has yet to be established. In addition to myocyte contractility, myocardial performance relies heavily on the cardiac extracellular matrix (ECM), the roles of which are as dynamic as they are significant; including providing structural integrity, assisting in force transmission throughout the cardiac cycle and acting as a signaling medium for communication between cells and the extracellular environment. In the healthy heart, ECM homeostasis must be maintained, and matrix deposition is in balance with degradation. Consequently, alterations to, or misregulation of the cardiac ECM has been shown to occur in both aging and in pathological remodeling with disease. Mounting evidence suggests that age-induced matrix remodeling may occur at the level of ECM control; including collagen synthesis, deposition, maturation, and degradation. Furthermore, experimental studies using aged animal models not only suggest that the aged heart may respond differently to insult than the young, but the identification of key players specific to remodeling with age may hold future therapeutic potential for the treatment of cardiac dysfunction in the elderly. This review will focus on the role of the cardiac interstitium in the physiology of the aging myocardium, with particular emphasis on the implications to age-related remodeling in disease.

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Ion Channels in the Heart

Bartos

Grandi

Ripplinger

2015

Comprehensive Physiology

156

182

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Optimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electrical properties of various components of the system, including the sinoatrial node, atria, atrioventricular node, His-Purkinje system, and ventricles. Here we review the major regionally-determined electrical properties of these cardiac regions and present the available data regarding the molecular and ionic bases of regional cardiac function and dysfunction. Understanding these differences is of fundamental importance for the investigation of arrhythmia mechanisms and pharmacotherapy.

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Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation

Cited by 47 publications

References 33 publications

Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils

Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils

Cardiac Physiology of Aging: Extracellular Considerations

Ion Channels in the Heart

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