Alterations in complement and coagulation pathways of human placentae subjected to in vitro fertilization and embryo transfer in the first trimester

Zhao, Liang; Sun, Lifang; Zheng, Xiuli; Liu, Jingfang; Zheng, Rong; Yang, Rui; Wang, Ying

doi:10.1097/md.0000000000017031

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…All complement components along with the plasminogen precursor, the factor XIIa inhibitor precursor, the P-selectin precursor, the alpha-1-antiproteinase precursor, prothrombin, alpha-2-antiplasmin, and the coagulation factor V involved in the cascade were downregulated in CPL-treated samples. Previous studies have indicated that overactivation of this system has associated factors in many pregnancy complications as the cascade deposits several split products on the cell membrane, ultimately creating a cytotoxic cell lysis complex, inflammation, and tissue injury including free circulating anaphylatoxins such as C3a and C5a [52]. This might suggest that CPL not only treated NEB but also reduced the associated reproductive complications.…”

Section: Discussionmentioning

confidence: 99%

Integrated Metabolomics and Proteomics Dynamics of Serum Samples Reveals Dietary Zeolite Clinoptilolite Supplementation Restores Energy Balance in High Yielding Dairy Cows

et al. 2021

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Dairy cows can suffer from a negative energy balance (NEB) during their transition from the dry period to early lactation, which can increase the risk of postpartum diseases such as clinical ketosis, mastitis, and fatty liver. Zeolite clinoptilolite (CPL), due to its ion-exchange property, has often been used to treat NEB in animals. However, limited information is available on the dynamics of global metabolomics and proteomic profiles in serum that could provide a better understanding of the associated altered biological pathways in response to CPL. Thus, in the present study, a total 64 serum samples were collected from 8 control and 8 CPL-treated cows at different time points in the prepartum and postpartum stages. Labelled proteomics and untargeted metabolomics resulted in identification of 64 and 21 differentially expressed proteins and metabolites, respectively, which appear to play key roles in restoring energy balance (EB) after CPL supplementation. Joint pathway and interaction analysis revealed cross-talks among valproic acid, leucic acid, glycerol, fibronectin, and kinninogen-1, which could be responsible for restoring NEB. By using a global proteomics and metabolomics strategy, the present study concluded that CPL supplementation could lower NEB in just a few weeks, and explained the possible underlying pathways employed by CPL.

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Section: Discussionmentioning

confidence: 99%

Integrated Metabolomics and Proteomics Dynamics of Serum Samples Reveals Dietary Zeolite Clinoptilolite Supplementation Restores Energy Balance in High Yielding Dairy Cows

et al. 2021

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“…In pregnancies resulting from in vitro fertilization and embryo transfer, the incidence of adverse pregnancy outcomes tends to be greater. Zhao et al ( 77 ) hypothesized that this may be due to changes in complement and/or coagulation pathways. Placentas were obtained in the first trimester following in vitro fertilization and embryo transfer and processed for microarray analysis.…”

Section: Complement From Implantation Through Placental Developmentmentioning

confidence: 99%

Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond

et al. 2020

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The complement cascade was identified over 100 years ago, yet investigation of its role in pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal interface prevent inappropriate complement activation to protect the fetus. However, this versatile proteolytic cascade also favorably influences numerous stages of pregnancy, including implantation, fetal development, and labor. Inappropriate complement activation in pregnancy can have adverse lifelong sequelae for both mother and child. This review summarizes the current understanding of complement activation during all stages of pregnancy. In addition, consequences of complement dysregulation during adverse pregnancy outcomes from miscarriage, preeclampsia, and pre-term birth are examined. Finally, future research directions into complement activation during pregnancy are considered.

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“…A soluble form of GCD59 shed from cell membranes can be measured with a highly sensitive and specific enzymelinked immunosorbent assay (ELISA) test (2). Zhao et al (10) found that downregulation of CD59 predisposed the placenta to increased complement activation and complementmediated damage as compared to normal pregnancy.…”

mentioning

confidence: 99%

The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

Bogdanet

Luque-Fernandez

Toth-Castillo

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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OBJECTIVE The aim of this study was to assess the association between early pregnancy maternal levels of plasma glycated CD59 (pGCD59) and neonatal hypoglycaemia (NH). MATERIALS and METHODS This is an observational study of pregnant women with a pre-pregnancy body mass index (BMI) ≥ 29 kg/m2 screened for eligibility to participate in the Vitamin D and Lifestyle Intervention for Gestational Diabetes (DALI) trial. This analysis included 399 pregnancies. Levels of pGCD59, were measured in fasting maternal samples taken at the time of a 75 g, 2-hour oral glucose tolerance test (OGTT) performed in early pregnancy (<20 weeks). NH, the study outcome, was defined as a heel-prick capillary glucose level of less than 2.6 mmol/L within 48 h of delivery. RESULTS We identified 30 infants with NH. Maternal levels of pGCD59 in early pregnancy, were positively associated with the prevalence of NH (ANOVA one-way, p-value <0.001). The odds of NH were higher in infants from mothers in the Tertile 3 of pGCD59 levels as compared to those from mothers in Tertile 1 (OR: 2.41, 95% CI: 1.03–5.63). However, this was attenuated when adjusted for maternal BMI (OR: 2.28 (95% CI: 0.96–5.43). The cross-validated area under the curve (AUC) was 0.64 (95% CI: 0.54–0.74), and adjusted for maternal BMI, age, and ethnicity, the AUC was 0.70 (95% CI: 0.56–0.78). CONCLUSION Although pGCD59 levels in early pregnancy in women with BMI ≥29 kg/m2 are associated with NH, our results indicate that this biomarker by itself is only a fair predictor of NH.

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Alterations in complement and coagulation pathways of human placentae subjected to in vitro fertilization and embryo transfer in the first trimester

Cited by 6 publications

References 49 publications

Integrated Metabolomics and Proteomics Dynamics of Serum Samples Reveals Dietary Zeolite Clinoptilolite Supplementation Restores Energy Balance in High Yielding Dairy Cows

Integrated Metabolomics and Proteomics Dynamics of Serum Samples Reveals Dietary Zeolite Clinoptilolite Supplementation Restores Energy Balance in High Yielding Dairy Cows

Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond

The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study

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