Alterations in circulating adiponectin levels occur rapidly after parturition

Abstract

Objective: To determine the levels of adiponectin and its subforms before and immediately after delivery to estimate the effect of cessating advanced pregnancy on circulating adiponectin levels. Design and methods: In a cohort of 37 women with uncomplicated singleton pregnancies and 6 women with twin pregnancies, serum adiponectin was measured before caesarean section (CS) in the fasting state, and 24 and 48 h after CS. Results: Serum adiponectin levels declined within 24 h of delivery from median 8.34 mg/l (range 5.57-20.47) to 6.81 mg/l (4.16-17.39) after 24 h and 6.84 mg/l (3.83-17.42) after 48 h. This corresponded to a relative decrease to 83G6 and 81G7% of pregnant values after 24 and 48 h respectively (P!0.001, ANOVA). In twin pregnancies, maternal adiponectin levels displayed a decrease that was the same as that displayed by them after birth (P!0.001). High-molecular weight adiponectin constituted 50G8% (range 34-68%) of total adiponectin. Absolute changes in adiponectin levels after delivery were most pronounced in this subfraction. The percentage medium-molecular weight adiponectin decreased slightly, but significantly (from 37G6 to 35G5%, P!0.001), and a similar statistically significant rise was observed in the low-molecular weight fraction (from 13G2 to 15G3%; P!0.001) within 48 h of delivery. Conclusions: Decreases in adiponectin levels occur shortly after delivery, and adiponectin subforms initiate the changes towards the non-pregnant state.

Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations

“…HM adiponectin was higher in mothers who delivered infants small for gestational age, as reported in previous studies [36] and in mothers of twins. Although the latter group was of low sample size in our cohort, the literature reports higher circulating adiponectin during twin pregnancies [40]. Elevated concentrations of circulating adiponectin are attributed to the larger placenta carried by mothers of twins [41] but are known to reduce significantly shortly after birth [40].…”

“…Although the latter group was of low sample size in our cohort, the literature reports higher circulating adiponectin during twin pregnancies [40]. Elevated concentrations of circulating adiponectin are attributed to the larger placenta carried by mothers of twins [41] but are known to reduce significantly shortly after birth [40]. Therefore, it is not clear how higher concentrations of adiponectin would remain in HM of mothers who gave birth to twins three months prior to HM sample collection.…”

Lower levels of human milk adiponectin predict offspring weight for age: a study in a lean population of Filipinos

“…; Fuglsang et al . ). In vitro evidence suggests a functional role for prolactin in suppressing adiponectin during lactation (Asai‐Sato et al .…”

The effect of antenatal factors and postnatal growth on serum adiponectin levels in children

“…Adiponectin may play a role in fetal linear growth by stimulating osteoblastic activity 18 and adipogenesis in animal models 19 . However, adiponectin does not seem to affect postnatal growth and, indeed, its concentration decreases during late fetal life, 20 immediately after delivery 21 and during infancy, 9 , 21 especially the high molecular weight sub-fraction 21 . The decline during infancy was attributed to increased weight (and possibly adiposity) and not to changes in insulin sensitivity 7 , which is compatible with our data.…”