Alterations in circadian rhythms following alcohol use: A systematic review

Meyrel, Manon; Rolland, Benjamin; Geoffroy, Pierre A.

doi:10.1016/j.pnpbp.2019.109831

Cited by 39 publications

(31 citation statements)

References 89 publications

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“…Eveningness individuals have a tendency to consume more psychoactive drugs, smoke, and drink more alcohol than morningness individuals [50,51]. Many studies have provided evidence that abnormalities in circadian rhythms may be associated to susceptibility to addiction [52,53]. For example, recent cross-sectional studies of inpatient clinics have shown that addiction disorders are more likely to be evening type than other patients [54].…”

Section: Discussionmentioning

confidence: 99%

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

et al. 2020

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Objective: Smartphones make our lives more convenient. To investigate the relationships between sleep-related habits, inattention, and smartphone addiction tendency (SAT), we determined how chronotype (morningness-eveningness) mediates these factors in Korean college students. Methods: Self-rated questionnaires including the Morningness-Eveningness Questionnaire, Smartphone Addiction Scale-Short Version, Adult Attention Deficit and Hyperactivity Disorder Scale, and Hospital Anxiety and Depression Scale were administered to 1,060 Korean college student smartphone users. This study investigated associations between sleep-related habits, social jetlag, inattention, anxiety, depression and SAT. A path analysis was conducted to evaluate the relationships, considering chronotype. Results: More social jetlag and smartphone use before bedtime had both direct and indirect relationships with SAT via eveningness in the path analysis model. Participants with shorter exposure to sunlight and more anxiety symptoms had a direct relationship with SAT. Individuals with a depressed mood, shorter sleep duration, and more inattentive features had no significant direct relationship with SAT but they had a significant indirect relationship with SAT via eveningness. Conclusion: The findings support the idea that chronotype plays a significant mediating role as a predictor of smartphone addiction. Managing modifiable variables and social jetlag as well as other clinical variables may help prevent and treat smartphone addiction in clinical practice.

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Section: Discussionmentioning

confidence: 99%

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

et al. 2020

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“…Resynchronization of circadian cortisol and CBT rhythms occurs approximately one month after leaving alcohol. Disruption of circadian melatonin rhythms may persist for 3–12 weeks [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Dual Diagnoses among Drug-Dependent Patients with Sleep Disorders

Roncero

García-Ullán

Bullón

et al. 2020

JCM

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Background: Sleep disorders are often associated with drug use. Nearly 70% of patients admitted for detoxification report sleep problems. Dual disorder (DD) is the comorbidity between mental disorders in general and disorders related to psychoactive substance use. The association between substance use and sleep disorders (SD) appears to be bidirectional. Our objective is to analyze the association between sleep disturbance history and drug use pattern (alcohol, cannabis, opioids, and cocaine). Methods: Analysis of data in the first interview at the Addictions Unit of the Department of Psychiatry at the University of Salamanca Health Care Complex between October 2017 and January 2020. The sample consists of 398 patients. We studied the association between different variables: origin of patients (Inpatient Dual Diagnosis Detoxification Unit (IDDDU) vs. Outpatient Drug Clinic (ODC), presence of affective disorder, psychotic disorder, type of drug used, and treatment. Results: Of patients with DD, 62% had more delayed sleep induction, sleep fragmentation, early awakening, and nightmares. Outpatients had more difficulty falling asleep because, in many cases, they had not previously sought any medical assistance. On the other hand, 67% of the patients with insomnia presented depression. Conclusions: There is evidence of a harmful association between DD and SD.

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“…Finally, given the role of BK channels in regulating neuronal excitability in the suprachiasmatic nucleus (the primary circadian pacemaker in mammals) [37, 38] and the desynchronization of biological rhythms observed in AUD [39, 40], we sought to determine whether the action of ethanol on BK channels could be responsible for a disruption of circadian rhythmicity in CIE-exposed mice. Under a standard light-dark cycle, the ambulation of CIE-exposed mice was significantly reduced up to withdrawal day 8 (vapor × time interaction: F 13,156 =10.3, p<0.0001, see Fig.…”

Section: Resultsmentioning

confidence: 99%

“…It is possible that this methodology is not sensitive enough or that concomitant 2BC experience is critical to detect sleep alteration. AUD have also been associated with a dysregulation of the circadian rhythm [40]. While CIE strongly reduced locomotor activity across both light and dark phases up to 8 days into withdrawal, it did not significantly affect free-running circadian period and amplitude.…”

Section: Discussionmentioning

confidence: 99%

Ethanol’s interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice

Okhuarobo

Kreifeldt

Bhattacharyya

et al. 2020

Preprint

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Large conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol. Whether the action of ethanol at BK channels influences the motivation to drink alcohol remains to be determined. In the present study, we sought to investigate the behavioral relevance of this interaction by introducing in the mouse genome a point mutation (BK α K361N) known to render BK channels insensitive to ethanol while preserving their physiological function. We demonstrate that preventing ethanol′s interaction with BK channels at this site hinders the escalation of voluntary alcohol intake induced by repeated cycles of alcohol intoxication and withdrawal. In contrast, the mutation does not alter ethanol′s acute behavioral effects, nor the metabolic and activity changes induced by chronic exposure to alcohol. Our findings point at BK channel ethanol-sensing capacity as a vulnerability mechanism in the transition from moderate alcohol consumption to pathological patterns of alcohol abuse.

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Alterations in circadian rhythms following alcohol use: A systematic review

Cited by 39 publications

References 89 publications

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

The Relevance of Dual Diagnoses among Drug-Dependent Patients with Sleep Disorders

Ethanol’s interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice

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