Alterations in cardiac autonomic function, lipid profile, and arterial stiffness in type 1 diabetic children

Shin, Ki Ok; Woo, Ji Eun; Yeo, Nam Hwoeh; Ok, Duckpil; Kang, Sunghwun

doi:10.1055/s-0036-1586362

Cited by 3 publications

(3 citation statements)

References 26 publications

(34 reference statements)

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“…Low ANS activity may also be associated with symptoms of coronary heart disease and related-risk factors in type 1 DM 8 ) . In our previous study 9 ) , ANS activity levels were significantly decreased in type 1 diabetic children in comparison with children without diabetes.…”

Section: Introductionmentioning

confidence: 67%

Exercise Training Improves Cardiac Autonomic Nervous System Activity in Type 1 Diabetic Children

et al. 2014

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[Purpose] We investigated the effect exercise training has on cardiac autonomic nervous system (ANS) and cardiovascular risk profiles in children with type 1 diabetes mellitus (DM). [Subjects] Fifteen type 1 DM children (all boys; 13.0±1.0 years of age) were enrolled in the study. [Methods] The subjects received exercise training three times a week in a 12-week program. Each child was asked to walk on a treadmill to achieve an exercise intensity of VO2max 60%. ANS activity was measured by power spectral analysis of the electrocardiogram (ECG). Blood samples were obtained for serum lipid profiles. To evaluate Doppler-shifted Fourier pulsatility index (PI) analysis, a 5-MHz continuous wave Doppler (VASCULAB D10) set was used to measure forward blood flow velocity (FLOW) in the radial artery. [Results] Total and low-frequency (LF) power of heart rate variability increased significantly after exercise intervention. Total cholesterol (TC) levels were significant lower after exercise intervention. Total and high-frequency (HF) power were significantly correlated with higher TC levels, but diastolic blood pressure and HF was significantly correlated with lower TC levels. [Conclusion] Regular exercise intervention should be prescribed for children with type 1 DM.

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Section: Introductionmentioning

confidence: 67%

Exercise Training Improves Cardiac Autonomic Nervous System Activity in Type 1 Diabetic Children

et al. 2014

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“…In non-diabetic children, glucose intolerance assessed during an oral glucose tolerance test (OGTT) predicts adult premature death (Franks et al 2010 ). The metabolic effects of elevated blood glucose (GLU) concentration ([GLU]) following an OGTT have implications for the arterial and autonomic systems, as evidenced by decreased autonomic modulation and increased vascular stiffness in diabetic adolescents (Shin et al 2010 ), which may contribute to chronic BRS dysfunction in youth with diabetes (Honzikova and Zavodna 2016 ). However, a lowered BRS caused by a rise in [GLU] is not only observed in diseased populations.…”

Section: Introductionmentioning

confidence: 99%

“…Although growth and maturation are associated with an augmented BRS due to maturation of the autonomic component (Lenard et al 2004 ), the influence of a glucose load on the BRS and its associated mechanisms is unknown in youth. As glucose intolerance is associated with poor vascular and autonomic functions in diabetic youth (Shin et al 2010 ), it is plausible that elevated [GLU] may reduce BRS in healthy adolescents. A better understanding of the BRS physiology under different challenges, such as during an OGTT, can help inform strategies to target cardiovascular disease risk reduction in paediatric groups.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise intensity on vascular and autonomic components of the baroreflex following glucose ingestion in adolescents

et al. 2019

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PurposeTo investigate the effects of an oral glucose tolerance test (OGTT) on baroreflex sensitivity (BRS) in a sample of healthy adolescents, and how acute exercise bouts of different intensities alter the effects of the OGTT on BRS.MethodsThirteen male adolescents (14.0 ± 0.5 years) completed three conditions on separate days in a counterbalanced order: (1) high-intensity interval exercise (HIIE); (2) moderate-intensity interval exercise (MIIE); and (3) resting control (CON). At ~ 90 min following the conditions, participants performed an OGTT. Supine heart rate and blood pressure were monitored continuously at baseline, 60 min following the conditions, and 60 min following the OGTT. A cross-spectral method (LFgain) was used to determine BRS gain. Arterial compliance (AC) was assessed as the BRS vascular component. LFgain divided by AC (LFgain/AC) was used as the autonomic component.ResultsAlthough non-significant, LFgain moderately decreased post-OGTT when no exercise was performed (pre-OGTT = 24.4 ± 8.2 ms mmHg− 1; post-OGTT = 19.9 ± 5.6 ms mmHg− 1; ES = 0.64, P > 0.05). This was attributed to the decrease in LFgain/AC (pre-OGTT = 1.19 ± 0.5 ms µm− 1; post-OGTT = 0.92 ± 0.24 ms µm− 1; ES = 0.69, P > 0.05). Compared to CON (Δ = − 4.4 ± 8.7 ms mmHg− 1), there were no differences for the pre–post-OGTT delta changes in LF/gain for HIIE (Δ = − 3.5 ± 8.2 ms mmHg− 1) and MIIE (Δ = 1.3 ± 9.9 ms mmHg− 1) had no effects on BRS following the OGTT (all ES < 0.5). Similarly, compared to CON (Δ = − 0.23 ± 0.40 ms µm− 1) there were no differences for the pre–post-OGTT delta changes in LF/gain for HIIE (Δ = − 0.22 ± 0.49 ms µm− 1) and MIIE (Δ = 0.13 ± 0.36 ms µm− 1).ConclusionA moderate non-significant decrease in BRS was observed in adolescents following a glucose challenge with no apparent effects of exercise.

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A High intensity Interval training (running and swimming) and resistance training intervention on heart rate variability and the selected biochemical factors in boys with type 1 diabetes

Saki,

Nazem,

Fariba

et al. 2023

Diabetes Research and Clinical Practice

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Alterations in cardiac autonomic function, lipid profile, and arterial stiffness in type 1 diabetic children

Cited by 3 publications

References 26 publications

Exercise Training Improves Cardiac Autonomic Nervous System Activity in Type 1 Diabetic Children

Exercise Training Improves Cardiac Autonomic Nervous System Activity in Type 1 Diabetic Children

Effects of exercise intensity on vascular and autonomic components of the baroreflex following glucose ingestion in adolescents

A High intensity Interval training (running and swimming) and resistance training intervention on heart rate variability and the selected biochemical factors in boys with type 1 diabetes

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