Alterations in brain hexokinase activity associated with streptozoticin-induced diabetes mellitus in the rat

Krukoff, Teresa L.; Patel, Kaushik P.

doi:10.1016/0006-8993(90)91593-6

Cited by 19 publications

(7 citation statements)

References 17 publications

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“…Evidence indicates that the PVN of the hypothalamus is involved in the blunted renal sympathoinhibition in response to acute volume expansion in the diabetic rat. We also demonstrated significant increases in the neural activity in the PVN of rats with diabetes (17). These data suggest that the neurons in the PVN are activated, and this may contribute to the autonomic dysfunction observed during diabetes.…”

supporting

confidence: 59%

Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes

Zheng

Liu

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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The study was conducted to investigate the role for dopamine in the centrally mediated sympathoexcitatory response in rats with Type 2 diabetes (T2D). T2D was induced by a combination of high-fat diet (HFD) and low-dose streptozotocin (STZ). HFD/STZ treatment for 12-14 wk resulted in significant increase in the number of FosB-positive cells in the paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM). In anesthetized rats, administration of exogenous dopamine (dopamine hydrochloride, 20 mM) in the PVN, but not in the RVLM, elicited decreases in renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) in control rats and but not in the T2D rats. Blocking the endogenous dopamine with dopamine D1/D5 receptor antagonist SCH39166 (2 mM) in the PVN and RVLM, resulted in increases in RSNA, MAP, and heart rate (HR) in both control and T2D rats. These responses were significantly attenuated in T2D rats compared with control rats (PVN - ΔRSNA: 21 ± 10 vs. 44 ± 2%; ΔMAP: 7 ± 3 vs. 19 ± 6 mmHg, ΔHR: 17 ± 5 vs. 32 ± 4 bpm, P < 0.05). There were no significant increases in response to dopamine D2/D3 receptor antagonist raclopride application in the PVN and RVLM of both control and T2D rats. Furthermore, there were decreased dopamine D1 receptor and D2 receptor expressions in the PVN of T2D rats. Taken together, these data suggest that reduced endogenous dopaminergic tone within the PVN may contribute to the sympathoexcitation in T2D.

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supporting

confidence: 59%

Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes

Zheng

Liu

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Pretreatment with capsaicin, a neurotoxin that causes selective degeneration of sensory Aδ and C fibers, abolished binding in the Amb, but didn't effect on the binding in the Pa5, NTS, and the spinal trigeminal nucleus suggesting the localization of B 2 receptors on post-synaptic afferent processes in the latter structures and on sensory terminals in the Amb (Couture and Lindsey 2000). Evidence suggests that the NTS could be involved in cardiovascular alterations in streptozotocininduced diabetic rats (Krukoff and Patel 1990) and in body weight and food intake in rats (Menani et al 1996). The Amb, where cardiac and visceral preganglionic vagal neurons originate (Massari et al 1995;Panneton et al 1996), has reciprocal connections with the caudal ventrolateral medulla (McKitrick and Calaresu 1997), and can selectively regulate the cardiac rate (Gatti et al 1996).…”

Section: Vagal Solitary Complexmentioning

confidence: 86%

Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive, and diabetic donors

Buck

Ongali²,

Thibault³

et al. 2002

Can. J. Physiol. Pharmacol.

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Kinins have been elected to the status of central neuromediators. Their effects are mediated through the activation of two G-protein-coupled receptors, denoted B, and B2. Functional and binding studies suggested that B1 and B2 receptors are upregulated in the medulla and spinal cord of hypertensive and diabetic rats. The aim of this study was to localize and quantify kinin receptors in post-mortem human medulla obtained from normotensive, hypertensive, and diabetic subjects, using in vitro receptor autoradiography with the radioligands [125I]HPP-HOE140 (B2 receptor) and [125I]HPP[des-Arg10]-HOE140 (B1 receptor). Data showed specific binding sites for B2 receptor (0.4-1.5 fmol/mg tissue) in 11 medullary nuclei from 4 control specimens (paratrigeminal > ambiguus > cuneate, gelatinous layer of the caudal spinal trigeminal nucleus > caudal and interpolar spinal trigeminal, external cuneate, solitary tract > hypoglossal > gracile > inferior olivary nuclei). Increased density of B2 receptor binding sites was observed in seven medullary nuclei of four hypertensive specimens (paratrigeminal > external cuneate > interpolar and caudal spinal trigeminal, gracile, inferior olivary > hypoglossal nuclei). B2 receptor binding sites were seemingly increased in the same medullary nuclei of two diabetic specimens. Specific binding sites for B1 receptor (1.05 and 1.36 fmol/mg tissue) were seen only in the inferior olivary nucleus in two out of the ten studied specimens. The present results support a putative role for kinins in the regulation of autonomic, nociceptive, and motor functions at the level of the human medulla. Evidence is also provided that B2 receptors are upregulated in medullary cardiovascular centers of subjects afflicted of cardiovascular diseases.

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“…Evidence indicates that the paraventricular nucleus (PVN) of the hypothalamus is involved in the blunted renal sympathoinhibition in response to acute volume expansion in the STZ-induced diabetic rat. We also have revealed significant increases in the neural activity in the PVN of rats with STZ-induced diabetes (18). This suggests that the neurons in the PVN are activated, and this may contribute to the autonomic dysfunction during type 1 diabetes.…”

mentioning

confidence: 94%

Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion

Patel¹,

Mayhan²,

Bidasee

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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Studies have shown that the superoxide mechanism is involved in angiotensin II (ANG II) signaling in the central nervous system. We hypothesized that ANG II activates sympathetic outflow by stimulation of superoxide anion in the paraventricular nucleus (PVN) of streptozotocin (STZ)-induced diabetic rats. In α-chloralose- and urethane-anesthetized rats, microinjection of ANG II into the PVN (50, 100, and 200 pmol) produced dose-dependent increases in renal sympathetic nerve activity (RSNA), arterial pressure (AP), and heart rate (HR) in control and STZ-induced diabetic rats. There was a potentiation of the increase in RSNA (35.0 ± 5.0 vs. 23.0 ± 4.3%, P < 0.05), AP, and HR due to ANG II type I (AT(1)) receptor activation in diabetic rats compared with control rats. Blocking endogenous AT(1) receptors within the PVN with AT(1) receptor antagonist losartan produced significantly greater decreases in RSNA, AP, and HR in diabetic rats compared with control rats. Concomitantly, there were significant increases in mRNA and protein expression of AT(1) receptor with increased superoxide levels and expression of NAD(P)H oxidase subunits p22(phox), p47(phox), and p67(phox) in the PVN of rats with diabetes. Pretreatment with losartan (10 mg·kg(-1)·day(-1) in drinking water for 3 wk) significantly reduced protein expression of NAD(P)H oxidase subunits (p22(phox) and p47(phox)) in the PVN of diabetic rats. Pretreatment with adenoviral vector-mediated overexpression of human cytoplasmic superoxide dismutase (AdCuZnSOD) within the PVN attenuated the increased central responses to ANG II in diabetes (RSNA: 20.4 ± 0.7 vs. 27.7 ± 2.1%, n = 6, P < 0.05). These data support the concept that superoxide anion contributes to an enhanced ANG II-mediated signaling in the PVN involved with the exaggerated sympathoexcitation in diabetes.

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Alterations in brain hexokinase activity associated with streptozoticin-induced diabetes mellitus in the rat

Cited by 19 publications

References 17 publications

Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes

Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes

Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive, and diabetic donors

Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion

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