Alterations in body composition in acromegaly

Katznelson, Laurence

doi:10.1007/s11102-008-0104-8

Cited by 65 publications

(51 citation statements)

References 59 publications

(82 reference statements)

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“…The measure of collagen synthesis, expressed as a fraction of the total collagen pool size, is only completely comparable between groups with similar collagen pool sizes (35). However, as acromegalic patients presumably have substantially larger collagen tissues compared to both healthy controls and GHD patients (36,37), our data imply that despite a significantly larger collagen pool, the FSR tended to be higher in patients with acromegaly. This means a higher musculoskeletal collagen turnover rate in acromegalic patients when expressed in absolute terms.…”

Section: Collagen and Myofibrillar Proteinmentioning

confidence: 58%

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Doessing¹,

Holm²,

Heinemeier³

et al. 2010

European Journal of Endocrinology

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Objective: Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1. Design and methods: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined. Results and conclusions: Muscle collagen I and III mRNA expression was higher in ACRO patients versus GHD patients (P!0.05), whereas collagen protein FSR did not differ significantly between ACRO and GHD patients in muscle (PZ0.21) and tendon (PZ0.15). IGF1Ea and IGF1Ec mRNA expression in muscle was higher in ACRO patients versus GHD patients (P!0.01). Muscle IGF1Ea mRNA expression correlated positively with collagen I mRNA expression (P!0.01). Tendon collagen fibrillar area tended to be higher in GHD patients relative to ACRO patients (PZ0.07). Thus, we observed a higher expression for collagen and IGF1 mRNA in local musculotendinous tissue in ACRO patients relative to GHD patients. Moreover, there was a tendency towards a higher collagen protein FSR and a smaller collagen fibril diameter in ACRO patients relative to GHD patients. The results indicate a collagenstimulating role of local IGF1 in human connective tissue and add to the understanding of musculoskeletal pathology in patients with either high or low GH/IGF1 axis activity.

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Section: Collagen and Myofibrillar Proteinmentioning

confidence: 58%

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Doessing¹,

Holm²,

Heinemeier³

et al. 2010

European Journal of Endocrinology

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“…GH plays an important role in the regulation of body composition, promoting a lean phenotype by increasing lipolysis in WAT and enhancing protein synthesis in muscle (Møller & Jørgensen 2009). In humans, acromegaly leads to an increase in body water and lean body mass (Ikkos et al 1954, O'Sullivan et al 1994, Kamenický et al 2014, associated with a reduction in body fat (Freda et al 2008, Katznelson 2009. Similarly, giant bovine-GH transgenic mice (bGH) exhibit a lower body fat percentage, smaller WAT deposits and lower serum leptin levels (Berryman et al 2004, Benencia et al 2014.…”

Section: Discussionmentioning

confidence: 99%

Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice

Lecoq

Zizzari

Hage

et al. 2016

Journal of Endocrinology

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Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of Aip (Aip +/− ) also develop pituitary adenomas but differ from AIP-mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was to determine the endocrine phenotype of Aip +/− mice by assessing the somatic growth, ultradian pattern of GH secretion and IGF1 concentrations of longitudinally followed male mice at 3 and 12 months of age. As the early stages of pituitary tumorigenesis are controversial, we also studied the pituitary histology and somatotroph cell proliferation in these mice. Aip +/− mice did not develop gigantism but exhibited a leaner phenotype than wild-type mice. Analysis of GH pulsatility by deconvolution in 12-month-old Aip +/− mice showed a mild increase in total GH secretion, a conserved GH pulsatility pattern, but a normal IGF1 concentration. No pituitary adenomas were detected up to 12 months of age. An increased ex vivo response to GHRH of pituitary explants from 3-month-old Aip +/− mice, together with areas of enlarged acini identified on reticulin staining in the pituitary of some Aip +/− mice, was suggestive of somatotroph hyperplasia. Global heterozygous Aip deficiency in mice is accompanied by subtle increase in GH secretion, which does not result in gigantism. The absence of pituitary adenomas in 12-month-old Aip +/− mice in our experimental conditions demonstrates the important phenotypic variability of this congenic mouse model.

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“…The majority of authors describe an increase in lean mass and a decrease in fat mass of acromegalic patients [10][11][12][13]. However, data on bone mineral density (BMD) in these patients are still conflicting.…”

Section: Introductionmentioning

confidence: 99%