Alterations in blood lipids and side effects induced by depo-provera in Nigerian women

Fajumi, James O.

doi:10.1016/0010-7824(83)90087-2

Cited by 18 publications

(5 citation statements)

References 14 publications

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“…This finding is in agreement with the previous studies [6, 13, 14]. Unlike our study, the studies by Grönroos and Lehtonen [3] and Fajumi [15] showed a decrease in TC levels, whereas those by Faddah et al [6] and Garza-Flores et al [5] did not show any changes in TC levels in DMPA users. Neither HDL-C nor TG levels were affected in DMPA users.…”

supporting

confidence: 93%

Effects of Long-term Use of Depo-medroxyprogesterone Acetate on Lipid Metabolism in Nepalese Women

et al. 2011

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Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women who had been using DMPA for more than 2 yr and age- and weight-matched control subjects who were not using hormonal contraceptives. Fasting blood samples were collected from the subjects for the estimation of total cholesterol (TC) and triglyceride (TG) levels, and the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were estimated using the Friedewald's equation. TC and LDL-C levels in DMPA users were significantly higher than those in non-users. Our study concluded that DMPA use induces lipid metabolism changes that can increase the risk of cardiovascular diseases.

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supporting

confidence: 93%

Effects of Long-term Use of Depo-medroxyprogesterone Acetate on Lipid Metabolism in Nepalese Women

et al. 2011

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“…1,2 Both weight gain and weight loss may occur with hormonal contraceptives. Weight gain, weight loss, or no change in weight may occur with oral contraceptives, [3][4][5] injectable contraceptives, [6][7][8][9][10][11][12] and progestogen contraceptive implants. [13][14][15] Clients using the Norplant subdermal implants in Zaria have previously been reported to gain a mean of 0.3kg after one year of use, and 1.1kg after five years, or lose a mean of 0.2kg after three years.…”

Section: Introductionmentioning

confidence: 99%

“…16 Clients who gain 5% or more of their baseline weight after three months of contraceptive use are more likely to gain even more weight after one year of use. 6 Weight gain occurs more in association with use of injectable hormonal contraceptives as compared to oral contraceptives. 5 Although weight changes are usually classified as minor side effects, excessive weight gain may increase the risk of cardiovascular and metabolic side effects of hormonal contraceptives.…”

Section: Introductionmentioning

confidence: 99%

Weight Changes in Clients on Hormonal Contraceptives in Zaria, Nigeria

Sule¹,

Shittu²

2005

African Journal of Reproductive Health

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Misconceptions exist in Nigeria about the effects of hormonal contraceptives on weight, which may have negative effects on contraceptive use. Data from case notes of clients attending the reproductive health centre at the Ahmadu Bello University Teaching Hospital, Zaria, between 1993 and 1995, were analysed to determine the effects of hormonal contraceptives on body weight, comparing them to clients using intrauterine contraceptive devices. Weight changes were not significantly different in clients using hormonal contraceptives and those using intrauterine contraceptive devices. This information will be beneficial in contraceptive counselling for clients in this environment and provide a baseline for further research. RÉSUMÉIl existe des idées erronnées au Nigéria concernant les effets des contraceptifs hormonaux sur le poids, chose qui pourrait avoir des effets négatifs sur l'usage des contraceptifs. Les données recueillies des dossiers des clientes qui fréquentaient le centre de santé de la reproduction au Centre Hospitalier Universitaire Ahmadu Bello à Zaria, entre 1993 et 1995, ont été analysées pour déterminer les effets des contraceptifs hormonaux sur le poids corporel, en les comparant aux clientes qui utilisent les dispositifs inter-utérins comme méthodes contraceptives. Il n'y avait pas des différences importantes en ce qui concerne les modifications de poids chez les clientes qui utilisent les contraceptifs hormonaux et ceux qui utilisent les dispositifs intra-utérins. La consultation contraceptive profitera de ce renseignement pour les clients de ce milieu et fournira une ligne de base en vue d'une recherche plus approfondie. (Rev Afr Santé Reprod 2005; 9[2]: 92-100)

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“…Two others reported a beneficial effect 5,6. Findings from all these studies are limited because they are cross-sectional in design3,6-8 or have very small sample sizes 1,4,5,9-12. Only three large trials have been published which followed women for an extended period and they do not agree in their findings 13-15.…”

mentioning

confidence: 99%

Effect of Injectable and Oral Contraceptives on Serum Lipids

Berenson¹,

Rahman²,

Wilkinson

2009

Obstetrics &Amp; Gynecology

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Objective-To estimate the effects of using depot medroxyprogesterone acetate (DMPA) or oral contraceptives (OC) containing 20 micrograms ethinyl estradiol and 0.15 mg desogestrel on serum lipid levels.Methods-Serum lipids were measured at baseline and every 6 months thereafter for 3 years on 703 white, black, and Hispanic women using DMPA, OC, or nonhormonal (NH) birth control. DMPA discontinuers were followed for up to 2 additional years.Participants completed questionnaires containing demographic and behavioral measures every 6 months and underwent 24 hour dietary recalls annually. Mixed model regression analyses and general estimating equations procedures were used to estimate changes over time in lipids by method, along with their predictors.Results-OC users experienced significantly greater increases in levels of triglycerides (TG), total cholesterol (TC), very low density lipoprotein cholesterol (VLDL-C), and high density lipoprotein cholesterol (HDL-C) than NH users (P<.001). However, no difference was noted in the LDL-C to HDL-C ratio between OC and NH users. Among DMPA users, HDL-C levels initially decreased for 6 months, but then returned to baseline. The LDL-C to HDL-C ratio rose during the first 6 months of DMPA use, but then dropped back to baseline over the next 24 months. After DMPA was discontinued, women who used OC increased their TG, TC, VLDL-C, and HDL-C levels significantly more than those who chose NH (P< .05).Conclusion-Use of very low dose OC containing desogestrel can elevate lipid levels. DMPA users were at increased risk of developing an abnormally low HDL-C level as well as an abnormally high LDL level and an increase in the LDL to HDL cholesterol ratio, although these effects appeared to be temporary.Although a number of investigations have been conducted on the relationship between depot medroxyprogesterone acetate (DMPA) and lipid levels, results are not consistent between studies. For example, some have demonstrated that DMPA does not effect serum lipids while others have shown an adverse relationship. [1][2][3][4] Two others reported a beneficial effect. 5,6 Findings from all these studies are limited because they are cross-sectional in design 3,[6][7][8] or have very small sample sizes. 1,4,5,[9][10][11][12] Only three large trials have been published which NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript followed women for an extended period and they do not agree in their findings. [13][14][15] Furthermore, none of these three studies took into account the effect of diet on lipid levels.Moreover, data are limited on the effects of oral contraceptives (OC) containing only 20 micrograms ethinyl estradiol (EE) and 0.15 mg desogestrel on the lipid profile. This third generation progestin has been used in newer birth control pills because it is less androgenic and thus should have less effect on carbohydrate metabolism and lipid levels. It is not certain, however, whether this actually occurs with use of OC containing only 20 micrograms ethinyl estr...

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Alterations in blood lipids and side effects induced by depo-provera in Nigerian women

Cited by 18 publications

References 14 publications

Effects of Long-term Use of Depo-medroxyprogesterone Acetate on Lipid Metabolism in Nepalese Women

Effects of Long-term Use of Depo-medroxyprogesterone Acetate on Lipid Metabolism in Nepalese Women

Weight Changes in Clients on Hormonal Contraceptives in Zaria, Nigeria

Effect of Injectable and Oral Contraceptives on Serum Lipids

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