Alterations in Blood Components

Carter, C.M.

doi:10.1016/b978-0-12-801238-3.64251-4

Cited by 12 publications

(11 citation statements)

References 366 publications

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“…This difference was probably due to a number of reasons. First, CRP has a long half-life (~19 hour) 39 and is relatively stable compared with blood cells, for example, the half-life of neutrophils is 7 hour, 40 and platelet turnover is increased in GDM. 41 Furthermore, CRP is measured by highly sensitive assays and increases nonspecifically in inflammatory settings.…”

Section: Discussionmentioning

confidence: 99%

Low-Grade Inflammation in Gestational Diabetes Mellitus and Its Correlation with Maternal Insulin Resistance and Fetal Growth Indices

Nguyen¹,

Minh²,

Dinh³

et al. 2023

IJGM

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Introduction Chronic low-grade inflammation (LGI) plays a role in the pathogenesis of gestational diabetes mellitus (GDM). LGI, on the one hand, promotes insulin resistance and at the same time, affects fetal development. The study aimed to use clinically feasible means to evaluate the association between maternal LGI and maternal insulin resistance and fetal growth indices by ultrasound in the third trimester. Methods A crossectional and descriptive study on 248 first-time diagnosed GDM in Vietnam. Results Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) indices were significantly higher in GDM than in normal glucose-tolerant pregnancies (p = 0.048 and 0.016, respectively). GDM with LGI witnessed significantly higher systolic blood pressure, BMI, HbA1c, and significantly lower quantitative Insulin Sensitivity Check Index (QUICKI) than those without LGI. After adjusting for maternal BMI, fasting plasma glucose (FPG), age, and parity, C-reactive protein (CRP) was positively correlated with HOMA2-IR (B=0.13, p<0.01) and Mathews index (B=0.29, p<0.01). Regarding fetal characteristics, LGI was associated with fetal growth indices in the third trimester of GDM. NLR was negatively correlated with estimated fetal weight (EFW) (B=−64.4, p<0.05) after adjusting for maternal BMI and FPG. After adjusting for maternal BMI, FPG, age, and parity, PLR was negatively correlated with biparietal diameter (B=−0.02, p<0.01) and abdominal circumference (AC) (B=−0.16, p<0.05), and EFW (B=−1.1, p<0.01), and head circumference (HC) (B=−0.06, p<0.01); CRP was negatively correlated with AC (B=−0.16, p<0.001), EFW (B=−85.3, p<0.001), and HC (B=−5.0, p<0.001). Conclusion In the third trimester, LGI was associated with maternal glucose and insulin resistance in GDM. Moreover, LGI was associated with fetal characteristics in ultrasonic images. There were negative correlations between LGI and fetal developmental characteristics.

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Section: Discussionmentioning

confidence: 99%

Low-Grade Inflammation in Gestational Diabetes Mellitus and Its Correlation with Maternal Insulin Resistance and Fetal Growth Indices

Nguyen¹,

Minh²,

Dinh³

et al. 2023

IJGM

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“…These changes in leukogram may relate to acute inflammatory condition in the body, which may induce the increase in blood lymphocyte number in rats along with increasing the monocytes, eosinophils, and basophils number (Stockham and Scott 2008; Weiss and Wardrop ‫)0102‬ , while the neutropenia in this condition arises from emigration neutrophils to tissues that exceed the bone marrow capacity to release neutrophils. Proinflammatory mediators and chemoattractants act on stimulate an increase in neutrophil margination besides firm adhesion to endothelial cells and tissue emigration, which cause the neutrophils circulating half-lives to be shorter and lowering the circulating neutrophils' pool (Carter 2018).…”

Section: Discussionmentioning

confidence: 99%

Assessment toxic effects of exposure to 3-indoleacetic acid via hemato-biochemical, hormonal, and histopathological screening in rats

Ismail

2022

Environ Sci Pollut Res

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The current study purposed to investigate the 3-indoleacetic acid (IAA) possible adverse impacts on hematological parameters, hepatorenal function, cardiac, and skeletal muscles as well as testes of rats and histopathological alterations of respective organs and to determine the extent of reversing any adverse impacts occurred in animals after IAA withdrawal. Rats were exposed orally to 500 mg/kg BW by gastric intubation once daily for 14 days, after which one-half was sacrificed and the remaining half left for a further 14 days without IAA exposure. The exposure of rats to IAA produced anemia, leukopenia, neutrophilia, lymphopenia, and a significant increase in activities of serum transaminase, gamma-glutamyl transferase, creatine kinase-myocardial band, creatine kinase-muscle type, and levels of serum creatinine, sodium, chloride, and potassium. Furthermore, serum levels of testosterone, gonadotropins, and leptin significantly declined. The changes in most of measured parameters continued after IAA withdrawal. Histopathological alterations in different tissues supported these changes. In conclusion, subacute exposure to IAA at a high concentration could exert hematotoxicity and toxic effects on many soft organs and its withdrawal led to incomplete recovery of animals. Thus, IAA should be used cautiously as extensive use of it at high concentrations can cause harmful effects on the environment, animals and human beings.

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“…Despite the fact that these play an important role in erythropoiesis and cell proliferation, there is also an exaggerated consumption of iron, folic acid and cobalamin, which shortens the half-life of the blood components producing leukopenia and plaquetopinia, indicative of bone marrow hypoplasia and associated its hypersplenism in hyperthyroid patients (Carter, 2018). In various biochemical tests, thyroid hormone has been shown to inhibit insulin receptors and increase beta-adrenergic receptors on the surface of leukocytes (Lee, 2020).…”

Section: Case Study Analysismentioning

confidence: 99%

“…In various biochemical tests, thyroid hormone has been shown to inhibit insulin receptors and increase beta-adrenergic receptors on the surface of leukocytes (Lee, 2020). The percentage of hematological sympathies in patients, cases of anemia can be observed usually 10-34%, leukopenia, neutropenia generally 15-30%, thrombocytopenia 2-5%, pancytopenia 23% (Carter, 2018).…”

Section: Case Study Analysismentioning

confidence: 99%

Normal anemia caused by endocrine disease

Muneizel

2022

ijhs

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Anemia is a common condition in patients with thyroid disorders. This paper focuses on demonstrating that changes in hemoglobin concentration, hematocrit, red blood cell count and erythrocyte indices influence the development of this pathology. The reduced half-life and decreased erythropoietin production of red blood cells and proliferation of blood cell precursors in the bone marrow made it possible to establish a relationship between the patient's symptoms and the prevailing laboratory findings between anemia and hypothyroidism.

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Alterations in Blood Components

Cited by 12 publications

References 366 publications

Low-Grade Inflammation in Gestational Diabetes Mellitus and Its Correlation with Maternal Insulin Resistance and Fetal Growth Indices

Low-Grade Inflammation in Gestational Diabetes Mellitus and Its Correlation with Maternal Insulin Resistance and Fetal Growth Indices

Assessment toxic effects of exposure to 3-indoleacetic acid via hemato-biochemical, hormonal, and histopathological screening in rats

Normal anemia caused by endocrine disease

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