Alterations in Biologic Oxidation in Thyrotoxicosis

Williams, Robert H.

doi:10.1001/archinte.1943.00210090054005

Cited by 21 publications

(9 citation statements)

References 43 publications

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“…Impairment of myocardial energy production due to altered enzyme function may have been a factor involved in the failure of an adequate cardiac output response to exercise (31)(32)(33)(34)(35). The action of thyroxin on myocardial function may well be mediated by sensitization of the myocardium to sympathetic nerve stimulation and to sympathomimetic amines (36)(37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

A Correlation of Clinical and Hemodynamic Studies in Patients With Hyperthyroidism With and Without Congestive Heart Failure *

Graettinger¹,

Muenster²,

Selverstone³

et al. 1959

J. Clin. Invest.

127

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Section: Discussionmentioning

confidence: 99%

A Correlation of Clinical and Hemodynamic Studies in Patients With Hyperthyroidism With and Without Congestive Heart Failure *

Graettinger¹,

Muenster²,

Selverstone³

et al. 1959

J. Clin. Invest.

127

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“…The blood and liver vitamin contents were subnormal, and the excretion was higher than normal (Williams et al, 1943). Tissue cocarboxylase content was low in hyperthyroid rats; it rose after thiamine was injected, but then fell more rapidly than in euthyroid animals, suggesting rapid destruction (Peters & Rossiter, 1939).…”

Section: Vitamin Metabolismmentioning

confidence: 89%

Biochemistry of hyperthyroidism and hypothyroidism

Hoch

1968

Postgraduate Medical Journal

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SummaryThe thyroid hormones act directly on mitochondria, and thereby control the transformation of the energy derived from oxidations into a form utilizable by the cell. Through their direct actions on mitochondria, the hormones also control indirectly the rate of protein synthesis and thereby the amount of oxidative apparatus in the cell. A rationale for the effects of thyroid hormone excess or deficiency is based upon studies of the mechanism of thyroid hormone action. In hypothyroidism, slow fuel consumption leads to a low output of utilizable energy. In hyperthyroidism, rapid fuel consumption leads to a high energy output, but as efficiency decreases, the utilizable energy produced decreases. Many of the chemical and physical features of these diseases can be reduced to changes in available energy.

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“…Intravenous injection of galactose or glucose in the presence of a raised level of thyroid hormones in the body does not give a constant picture. Some workers [22] describe a normal type of blood sugar curve whereas others [ 648] observed a delayed type of curve characteristic of diabetes. It is difficult to reconcile these facts with the more rapid utilization of glucos~ by the tissues mentioned above.…”

Section: Metabolismmentioning

confidence: 99%

Physiological Effects of the Thyroid Hormones

et al. 1975

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The thyroid gland has a powerful influence over the activities of the whole body. If the function of the gland is for any reason lost, serious disturbances of chemical and morphological structure arise and are manifested as physical and mental disorders. The diversity of the action of thyroid hormones on physiological functions, on the metabolic rate, and on the activity of various enzyme systems both in the body as a whole and in tissue preparations has been known for a long time. Our knowledge of the role of thyroid hormones is based on experiments in which a particular thyroid hormone has been given to healthy and athyrotic animals and on extensive clinical observations on patients with hyperthyroid and hypothyroid states.The effect of thyroid hormones in vivo is expressed as reactions of whole organs and of individual physiological functions and morphological structures. The internal secretions of the thyroid gland modify growth and metamorphosis, the utilization of oxygen by the body as a whole or by tissue preparations in vitro, various aspects of metabolism, and the activity of particular enzyme systems.The extreme diversity of the effects observed after injection of thyroid hormone may reflect the primary action of this agent on a single link fundamental to the mechanism of biochemical processes in the cell or on a single morphological structure responsible for the proper integration of processes at the cell level. These problems will be examined fully later. Here I shall merely state that when the action of a thyroid hormone is discussed, the term is used not only with respect to the thyroxine and triiodothyronine produced in the thyroid gland, but also to several of their derivatives and analogs. However, we know that all compounds with the biological activity 125 Y. K. Turakulov et al., Thyroid Hormones

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Alterations in Biologic Oxidation in Thyrotoxicosis

Cited by 21 publications

References 43 publications

A Correlation of Clinical and Hemodynamic Studies in Patients With Hyperthyroidism With and Without Congestive Heart Failure *

A Correlation of Clinical and Hemodynamic Studies in Patients With Hyperthyroidism With and Without Congestive Heart Failure *

Biochemistry of hyperthyroidism and hypothyroidism

Physiological Effects of the Thyroid Hormones

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