Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium

Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder

“…This finding corresponds with the result of some previous reports [11,14,17,27], but not all [13,28]. However, serum BDNF levels did not differ significantly between bipolar patients in a manic phase and a depressive phase, which is compatible with previous reports [13,28], and incompatible with the previous report [17].…”

“…Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder during manic or depressive episode compared to healthy controls [13,14,27]. In addition, Piccinni, et al found that the plasma BDNF levels were significantly decreased in the course of mixed episodes of bipolar disorder [29].…”

Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania

“…In agreement with our results, Jornada and colleagues [18] also demonstrated that ouabain decreased the levels of BDNF in the hippocampus and amygdala of rats. It is well described in the literature that BDNF have an import role in the physiopathology and pharmacological treatment of BD [10][11][12][13]. Taking into account that BDNF have an important role in the neurogenesis and cognition [48][49][50], we can suggest that the decrease of Na + K + ATPase by ouabain can induces some cognition alteration, with are widely observed in bipolar patients.…”

“…BDNF binds to the receptor tyrosine kinase B (TrKB), activating diverse intracellular cascades involved in cellular survival and growth [9]. Studies showing decreased peripheral BDNF levels during manic and depressive episodes suggest that this neurotrophin may be an important target for the understanding of BD pathophysiology [10][11][12][13]. Postmortem studies also have demonstrated that BDNF levels and TrkB, its receptor, decreased in brain from bipolar patients [14,15].…”

Bipolar bozuklukta allostaz ve allostatik yükü yeniden değerlendirmek

“…Recent studies reported decreased BDNF and increased glia-derived neurotrophic factor (GDNF) levels in both mania and depression (17), increased GDNF/BDNF ratio in mania (18), and increased GDNF levels during manic switch due to ECT (19) confirming the role of the disrupted supportive cellular network in BD. Altered antioxidant enzymes, lipid peroxidation and nitric oxide levels (20)(21)(22), as well as increased DNA damage (23)(24)(25)(26)(27) in BD and a probable coactivation of oxidative damage and repair mechanisms have been reported, particularly in a depressive state of BD (28).…”