Alterations in Apical Dendrite Bundling in the Somatosensory Cortex of 5-HT3A Receptor Knockout Mice

Smit-Rigter, Laura A.; Wadman, Wytse J.; Hooft, Johannes A. van

doi:10.3389/fnana.2011.00064

Cited by 12 publications

(10 citation statements)

References 28 publications

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“…Further, in line with the potential role of the 5-HT 3 receptor outlined earlier in this review, these animals display some alterations in neocortical development as hypercomplexity of apical dendrites of cortical layer II/III pyramidal neurons (Chameau et al, 2009) and increased apical dendrite bundling (Smit-Rigter et al, 2011). Disruptions of neocortical development, especially in the balance between excitatory and inhibitory circuits, might at least partially underlie autism neurobiology (Polleux and Lauder, 2004; Levitt, 2005).…”

Section: Putative Implications For Neurodevelopmental Disorderssupporting

confidence: 72%

“…The increased dendritic complexity of cortical layer II/III pyramidal neurons in 5-HT 3 receptor knock-out mice has been associated with altered cortical spatial organization and connectivity with larger dendritic bundles in layer III tangential sections, whereas spine density was not affected (Smit-Rigter et al, 2011). On a functional level, the increase in dendritic complexity of cortical layer II/III pyramidal neurons in 5-HT 3 receptor knock-out mice results in a different firing pattern of these cells (van der Velden et al, 2012), suggesting that 5-HT 3 receptor activity during maturation of neurons is not only important for the wiring of the local microcircuitry, but also consequently for the processing of information within the circuit.…”

Section: Expression Of 5-ht3 Receptors On Cerebellar Granule and Cortmentioning

confidence: 99%

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The serotonin 5-HT3 receptor: a novel neurodevelopmental target

Engel¹,

Smidt²,

Hooft³

2013

Front. Cell. Neurosci.

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Serotonin (5-hydroxytryptamine, 5-HT), next to being an important neurotransmitter, recently gained attention as a key-regulator of pre- and postnatal development in the mammalian central nervous system (CNS). Several receptors for 5-HT are expressed in the developing brain including a ligand-gated ion channel, the 5-HT3 receptor. Over the past years, evidence has been accumulating that 5-HT3 receptors are involved in the regulation of neurodevelopment by serotonin. Here, we review the spatial and temporal expression patterns of 5-HT3 receptors in the pre- and early postnatal rodent brain and its functional implications. First, 5-HT3 receptors are expressed on GABAergic interneurons in neocortex and limbic structures derived from the caudal ganglionic eminence. Mature inhibitory GABAergic interneurons fine-tune neuronal excitability and thus are crucial for the physiological function of the brain. Second, 5-HT3 receptors are expressed on specific glutamatergic neurons, Cajal–Retzius cells in the cortex and granule cells in the cerebellum, where they regulate morphology, positioning, and connectivity of the local microcircuitry. Taken together, the 5-HT3 receptor emerges as a potential key-regulator of network formation and function in the CNS, which could have a major impact on our understanding of neurodevelopmental disorders in which 5-HT plays a role.

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Section: Putative Implications For Neurodevelopmental Disorderssupporting

confidence: 72%

Section: Expression Of 5-ht3 Receptors On Cerebellar Granule and Cortmentioning

confidence: 99%

The serotonin 5-HT3 receptor: a novel neurodevelopmental target

Engel¹,

Smidt²,

Hooft³

2013

Front. Cell. Neurosci.

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“…A similar 5-HT sensitivity has been reported for layer 2/3 pyramidal neurons in the SSC, where increased 5-HT signaling from E8 to E18 decreases apical dendritic arborization (Chameau et al, 2009;Smit-Rigter et al, 2012). This latter effect is mediated by 5-HT 3A receptors present on reelin secreting Cajal-Retzius cells (Smit-Rigter et al, 2012), which upon activation stimulate the release of reelin, which in turn limits cortical neuron apical dendritic elaboration (Chameau et al, 2009;Smit-Rigter et al, 2011). As Cajal-Retzius cells are still present and active in the first two postnatal weeks, a similar mechanism involving hyperactivation of the 5-HT 3A receptors can be postulated for the cytoarchitectural changes observed following postnatal FLX treatment.…”

Section: Mechanistic Insight On the Postnatal Establishment Of Perturmentioning

confidence: 57%

Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Suri

Teixeira

Cagliostro

et al. 2014

Neuropsychopharmacol

141

125

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Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system development, such sensitive periods shape the formation of neurocircuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint as well as the environmental context. While allowing for adaptation, such sensitive periods are also vulnerability windows during which external and internal factors can confer risk to disorders by derailing otherwise resilient developmental programs. Here we review developmental periods that are sensitive to monoamine signaling and impact adult behaviors of relevance to psychiatry. Specifically, we review (1) a serotonin-sensitive period that impacts sensory system development, (2) a serotonin-sensitive period that impacts cognition, anxiety-and depressionrelated behaviors, and (3) a dopamine-and serotonin-sensitive period affecting aggression, impulsivity and behavioral response to psychostimulants. We discuss preclinical data to provide mechanistic insight, as well as epidemiological and clinical data to point out translational relevance. The field of translational developmental neuroscience has progressed exponentially providing solid conceptual advances and unprecedented mechanistic insight. With such knowledge at hand and important methodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental origins of neuropsychiatric disorders, and thus understanding pathophysiology. Such knowledge of sensitive periods that determine the developmental trajectory of complex behaviors is a necessary step towards improving prevention and treatment approaches for neuropsychiatric disorders.

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“…Furthermore, the effects of SSRIs on developing dendrites were abolished when administered in the 5-HT 3A :KO mice or after pharmacological blockade of the 5-HT 3A receptor [173,195]. Moreover, the fine tuning of 5-HT 3A signalling has been shown to be responsible for the anxiety-like behaviours that are induced by prenatal fluoxetine treatment in wild type mice [196].…”

Section: Serotonin and Dendritic Maturation Of Cortical Neuronsmentioning

confidence: 99%

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Vitalis¹,

Verney²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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The mammalian cerebral cortex is critical for sensory and motor integrations and, for higher-order cognitive functions. The construction of mammalian cortical circuits involves the coordinated interplay between cellular processes such as proliferation, migration and differentiation of neural and glial cell subtypes followed by accurate connectivity evolving in complexity in primates. Alteration in cortical development may induce the emergence of various pathological traits and behaviours. Among the large array of factors that regulate the assembly of cortical circuits, serotonin (5-HT) plays important role as a developmental signal that impacts on a broad diversity of cellular processes. 5-HT plays distinct roles during specific sensitive periods and is produced from various sources depending on the perinatal stage. Its roles are mediated by more than fourteen 5-HT receptors that are all G-protein coupled receptors except the ionotropic 5-HT type 3A receptor (5-HT 3A ) mediating rapid neuronal activation. Importantly, 5-HT metabolism and signalling are influenced by numerous epigenetic and genetic factors, including nutrition and gut microbiota, perinatal stress, infection and inflammation. In this review, we will recapitulate some evidences showing that dysregulation of 5-HT homeostasis and 5-HT 3A signalling impairs distinct steps of cortical circuit formation leading to the predisposition of the onset of various psychiatric diseases.

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Alterations in Apical Dendrite Bundling in the Somatosensory Cortex of 5-HT3A Receptor Knockout Mice

Cited by 12 publications

References 28 publications

The serotonin 5-HT3 receptor: a novel neurodevelopmental target

The serotonin 5-HT3 receptor: a novel neurodevelopmental target

Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

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