Alterations in antioxidant enzyme activities and oxidative damage in alcoholic rat tissues: Protective role of Thespesia populnea

Pandanaboina, Sahitya Chetan; Kondeti, Shanmugam Ramudu; Rajbanshi, Sangeetha L. A.; Kunala, Pavan; Pandanaboina, Saritha; Pandanaboina, Murali Mohan; Rajendra, Wudayagiri

doi:10.1016/j.foodchem.2011.10.046

Cited by 19 publications

(17 citation statements)

References 37 publications

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“…Xu (2000) who found that pumpkin polysaccharide could increase the SOD and GSH-Px activity and reduce the MDA content in tumor mice serum (Xu, 2000). Pandanaboina et al (2012) who observed a significant increase in lipid peroxidation during alcohol consumption, as reported by earlier studies (Das and Vasudevan, 2006). The alcohol intoxication increases lipid peroxide production (LPO) in various tissues, and is indicative of tissue oxidative stress.…”

Section: Resultssupporting

confidence: 80%

Ameliorative effect of pumpkin oil (Cucurbita pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats

Seif

2014

Beni-Suef University Journal of Basic and Applied Sciences

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Oxidative stress a b s t r a c tObjective: The aim of the present study was to evaluate the protective role of pumpkin oil on experimental alcohol e induced hepatotoxicity. Materials and methods: Rats are divided into three groups of 10 animals each. Group one (G1) was the control group is orally given distilled water for 4 weeks. Group two (G2) is given absolute ethyl alcohol (10%) in drinking water for 4 weeks. Group three (G3) alcohole administered rats were pretreated with pumpkin oil (50 mg/kg body weight) three times per week for three weeks and alcohol (10%) three times per week (at the first two weeks of the experiment). Results: Alcohol caused a marked rise in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (gGT) activities. Concerning oxidative stress and antioxidant defense system, the depleted hepatic glutathione content, glutathione-S-transferase and catalase activities of alcoholadministered rats were potentially increased above normal levels as a result of pretreatment with pumpkin oil. However, while elevated lipid peroxidation was noticed in alcohol treated rats, pretreatment with pumpkin oil produced a detectable decrease in lipid peroxidation level. Conclusion: The natural plant components found in pumpkin could improve the liver against alcohol-induced liver toxicity and oxidative stress. However, further clinical studies are required to assess the safety and benefits of pumpkin oil in human beings.

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Section: Resultssupporting

confidence: 80%

Ameliorative effect of pumpkin oil (Cucurbita pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats

Seif

2014

Beni-Suef University Journal of Basic and Applied Sciences

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“…The current results were in agreement with those of Pandanaboina et al [59], who observed a significant increase in lipid peroxidation during alcohol consumption, as reported by earlier studies [65]. The alcohol intoxication increases LPO production in various tissues, and is indicative of tissue oxidative stress.…”

Section: Discussionsupporting

confidence: 94%

“…Pandanaboina et al [59] found that alcohol treatment resulted in the depletion of superoxide dismutase, CAT, glutathione peroxidase, glutathione reductase, and GST activities, reduced the GSH content, increased the level of malondialdehyde, and decreased the levels of protein carbonyls, causing malfunction of hepatic and renal tissues.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of parsley oil (Petroselinum crispum) against alcohol-induced hepatotoxicity and oxidative stress

Seif¹

2014

Medical Research Journal

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“…Catalase is also an antioxidant enzyme that precipitates the decomposition of hydrogen peroxide into water and oxygen [17,37]. And GSH-Px is the general name for an enzyme family with peroxidase activity whose main biological role is to protect the cell protein and membrane from oxidation and reduces variable hydroperoxides [44]. Therefore, only when the concentration of GPx and CAT is in equal level with SOD, the antioxidant system can clear the ROS effectively.…”

Section: Effect Of Antioxidative Peptides On H 2 O 2 -Induced Cells Vmentioning

confidence: 99%

Protective effects against H2O2-induced oxidative damage in lung fibroblast cell by peptide isolated from plasma albumin hydrolysate

Wang

Zhang

et al. 2015

Eur Food Res Technol

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Alterations in antioxidant enzyme activities and oxidative damage in alcoholic rat tissues: Protective role of Thespesia populnea

Cited by 19 publications

References 37 publications

Ameliorative effect of pumpkin oil (Cucurbita pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats

Ameliorative effect of pumpkin oil (Cucurbita pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats

Ameliorative effect of parsley oil (Petroselinum crispum) against alcohol-induced hepatotoxicity and oxidative stress

Protective effects against H2O2-induced oxidative damage in lung fibroblast cell by peptide isolated from plasma albumin hydrolysate

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