Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala

Chiba, Shuichi; Okawara, Toru; Kawakami, Kotaro; Ohta, Ryo; Kawaguchi, Maiko

doi:10.1016/j.physbeh.2021.113670

Cited by 2 publications

(4 citation statements)

References 39 publications

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“…However, a classical study showed that hippocampal lesions were followed by a rapid and stable SIP acquisition [ 127 ]. Regarding increased amygdala, similar data was found in HD animals [ 101 ] and in the high-avoidance Hatano rats [ 128 ] that showed increased BLA volume.…”

Section: Discussionsupporting

confidence: 81%

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats

Martín-González,

Prados-Pardo,

Sawiak

et al. 2023

Behav Brain Funct

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Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior on a schedule-induced polydipsia (SIP) task. Regional brain morphology was assessed using ex-vivo high-resolution magnetic resonance imaging (MRI). Voxel-based morphometry of segmented MRI images revealed larger white matter volumes in anterior commissure and corpus callosum of HD rats compared with LD rats. HD rats also showed significantly larger regional volumes of dorsolateral orbitofrontal cortex, striatum, amygdala, hippocampus, midbrain, sub-thalamic nucleus, and cerebellum. By contrast, the medial prefrontal cortex was significantly smaller in HD rats compared with LD rats with no significant group differences in whole brain, ventricular, or cerebrospinal fluid volumes. These findings show that limbic cortico-basal ganglia structures implicated in impulse control disorders are distinct in rats that are vulnerable to develop compulsive behavior. Such abnormalities may be relevant to the etiology of compulsive disorders in humans.

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Section: Discussionsupporting

confidence: 81%

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats

Martín-González,

Prados-Pardo,

Sawiak

et al. 2023

Behav Brain Funct

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“…Currently, multiple protocols utilizing active avoidance are employed to investigate questions related to emotional reactivity [7,8], fear learning and fear extinction [9,10], stress reactivity [3,6,10,11], and depression-like behavior [12][13][14]. The amygdala is recognized as a major control center for acquiring and exhibiting avoidance behaviors [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…The hippocampus seems to have an influence on avoidance behavior, yet its involvement in learned active avoidance is still a mystery [9,19]. Active avoidance behavior has been shown to involve similar neural circuits in both animals and humans [1][2][3][4]9], and this test is used to validate animal models of neuropsychiatric disorders [1,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…It is surprising how few scientists have documented USVs during learning sessions in rats and used aversive ultrasonic calls as a sign of a negative emotional state. Recently, Shuichi Chiba et al (2022) analyzed 22 kHz ultrasonic calls as a measure of emotional reactivity in contextual fear conditioning in rats [7]. We recently demonstrated that adult males of the NEW substrain more often produced aversive USVs than females [29].…”

Section: Introductionmentioning

confidence: 99%

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The Difference between Male and Female Rats in Terms of Freezing and Aversive Ultrasonic Vocalization in an Active Avoidance Test

Alexandrov,

Pupikina,

Adaeva

et al. 2023

Physiologia

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We examined sex differences in behavioral responses to fear-related learning through ultrasonic vocalization. Adult male and female rats of two inbred rat strains (WAG/Rij rats with genetic predisposition absence epilepsy, n = 25; and the minor substrain NEW with non-epileptic phenotype, n = 32) were examined in the two-way active avoidance task (50 trials). Three behavioral responses were defined: successful learning, unsuccessful learning, and freezing (motionless behavior). We found that males were more likely to experience freezing (40%) than females (3.7%). Females performed significantly better than males: 93% of females showed “successful learning”, while only 43.2% of males did. Long-lasting 22 kHz ultrasonic calls, so-called aversive ultrasonic vocalizations aUSVs, were recorded in 26% of females (only successful learners) and in 50% of males. The density of aUSVs in females was lower than in males. WAG/Rij males performed much poorer than the NEW males. In general, males, in contrast to females, showed significantly poorer avoidance learning, more frequently experienced freezing, and produced more aversive USVs. Males thus experienced a negative emotional state, rather than exhibiting poor cognitive abilities. Perhaps, WAG/Rij rats and a minor NEW substrain showed an increased emotionally in fear-related tasks, because they are prone to emotional disorders or emotional exhaustion. Sex differences in freezing and in aUSVs might result from the poorly understood neuromodulatory effects of the cholinergic system.

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Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala

Cited by 2 publications

References 39 publications

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats

The Difference between Male and Female Rats in Terms of Freezing and Aversive Ultrasonic Vocalization in an Active Avoidance Test

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