Alteration of urinary profiles of endogenous steroids and polyunsaturated fatty acids in thyroid cancer

Kim, Kyung Mee; Jung, Byung Hwa; Lho, Dong-Seok; Chung, Woung Youn; Paeng, Ki‐Jung; Chung, Bong Chul

doi:10.1016/j.canlet.2003.08.002

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…Fatty acids are examples of molecules that could be encountered in their free form or enzymatically cleaved by bacteria or host from larger lipid molecules. The presence of fatty acids has been documented in many tissues that represent infection sites for K. pneumoniae (Farrell, Mischler, Engle, Brown, & Lau, ; Kim et al., ; Patil & Magar, ). To examine the effects of fatty acids on growth, a physiologically relevant concentration of fatty acid (300 μmol/L) was supplemented and chosen for all experiments.…”

Section: Resultsmentioning

confidence: 99%

Exogenous fatty acids alter phospholipid composition, membrane permeability, capacity for biofilm formation, and antimicrobial peptide susceptibility in Klebsiella pneumoniae

et al. 2018

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Klebsiella pneumoniae represents a major threat to human health due to a combination of its nosocomial emergence and a propensity for acquiring antibiotic resistance. Dissemination of the bacteria from its native intestinal location creates severe, complicated infections that are particularly problematic in healthcare settings. Thus, there is an urgency for identifying novel treatment regimens as the incidence of highly antibiotic-resistant bacteria rises. Recent findings have highlighted the ability of some Gram-negative bacteria to utilize exogenous fatty acids in ways that modify membrane phospholipids and influence virulence phenotypes, such as biofilm formation and antibiotic resistance. This study explores the ability of K. pneumoniae to assimilate and respond to exogenous fatty acids. The combination of thin-layer chromatography liquid chromatography-mass spectrometry confirmed adoption of numerous exogenous polyunsaturated fatty acids (PUFAs) into the phospholipid species of K. pneumoniae. Membrane permeability was variably affected as determined by two dye uptake assays. Furthermore, the availability of many PUFAs lowered the MICs to the antimicrobial peptides polymyxin B and colistin. Biofilm formation was significantly affected depending upon the supplemented fatty acid.

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Section: Resultsmentioning

confidence: 99%

Exogenous fatty acids alter phospholipid composition, membrane permeability, capacity for biofilm formation, and antimicrobial peptide susceptibility in Klebsiella pneumoniae

et al. 2018

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“…38 Moreover, two case-control studies found significantly lower urinary or serum levels of PUFA in TC cases than in controls. 39,40 In EPIC, the main food sources of PUFA intake are vegetable oils, nuts and seeds and fish. 41 Vegetable oils and especially nuts and seeds are rich in polyphenols that are well known for having several anticarcinogenic effects and have been inversely associated with TC risk in a large cohort study.…”

Section: Discussionmentioning

confidence: 99%

Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study

et al. 2015

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Incidence rates of differentiated thyroid carcinoma (TC) have increased in many countries. Adiposity and dietary risk factors may play a role, but little is known on the influence of energy intake and macronutrient composition. The aim of this study was to investigate the associations between TC and the intake of energy, macronutrients, glycemic index (GI) and glycemic load in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,274 middle‐age participants (70.2% women) from ten European countries. Dietary data were collected using country‐specific validated dietary questionnaires. Total carbohydrates, proteins, fats, saturated, monounsaturated and polyunsaturated fats (PUFA), starch, sugar, and fiber were computed as g/1,000 kcal. Multivariable Cox regression was used to calculate multivariable adjusted hazard ratios (HR) and 95% confidence interval (CI) by intake quartile (Q). After a mean follow‐up time of 11 years, differentiated TC was diagnosed in 556 participants (90% women). Overall, we found significant associations only with total energy (HRQ4vs.Q1, 1.29; 95% CI, 1.00–1.68) and PUFA intakes (HRQ4vs.Q1, 0.74; 95% CI, 0.57–0.95). However, the associations with starch and sugar intake and GI were significantly heterogeneous across body mass index (BMI) groups, i.e., positive associations with starch and GI were found in participants with a BMI ≥ 25 and with sugar intake in those with BMI < 25. Moreover, inverse associations with starch and GI were observed in subjects with BMI < 25. In conclusion, our results suggest that high total energy and low PUFA intakes may increase the risk of differentiated TC. Positive associations with starch intake and GI in participants with BMI ≥ 25 suggest that those persons may have a greater insulin response to high starch intake and GI than lean people.

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“…The derivatives have been used to determine, for example, androgens in human hair (Choi & Chung, ) with detection limits in the range of 0.12–8.45ng/g by GC/MS using selected ion monitoring of the molecular ions, and to measure testosterone and pregnenolone 3β‐hydroxypregn‐5‐en‐20‐one ( 238 ) in human nails (Choi et al, ). The relatively large retention increment attending derivatization, combined with good volatility has been used to advantage for moving peaks to clear regions of the chromatogram as illustrated by a recent isotope dilution assay for androgens in urine (Kim et al, ; Lee et al, ) and testosterone ( 228 ) and 5α‐dihydroxytestosterone in rat liver (Lee et al, ).…”

Section: Other Silyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy ethers. More complex compounds such as glycerides, sphingolipids, carbohydrates, organic phosphates, phosphonates, steroids, vitamin D, cannabinoids, and prostaglandins are discussed next. The second section describes intermolecular reactions of siliconium ions such as the TMS cation and the third section discusses other alkylsilyl derivatives. Among these latter compounds are di‐ and trialkyl‐silyl derivatives, various substituted‐alkyldimethylsilyl derivatives such as the tert‐butyldimethylsilyl ethers, cyclic silyl derivatives, alkoxysilyl derivatives, and 3‐pyridylmethyldimethylsilyl esters used for double bond location in fatty acid spectra. © 2019 Wiley Periodicals, Inc. Mass Spec Rev 0000:1–107, 2019

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Alteration of urinary profiles of endogenous steroids and polyunsaturated fatty acids in thyroid cancer

Cited by 15 publications

References 20 publications

Exogenous fatty acids alter phospholipid composition, membrane permeability, capacity for biofilm formation, and antimicrobial peptide susceptibility in Klebsiella pneumoniae

Exogenous fatty acids alter phospholipid composition, membrane permeability, capacity for biofilm formation, and antimicrobial peptide susceptibility in Klebsiella pneumoniae

Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

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