Alteration of the oral microbiota may be a responsible factor, along with estrogen deficiency, by the development of larger periapical lesions

Lucisano, Marília Pacifico; Pereira, Ana Patrícia de Sousa; Romualdo, Priscilla Coutinho; Feres, Magda; Queiroz, Alexandra Mussolino de; Nelson‐Filho, Paulo; Silva, Léa Assed Bezerra da

doi:10.1007/s00784-020-03688-5

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…The high serum levels of FSH and LH can affect OLP pathogenesis because of estrogen and progesterone modulation ( Lavaee et al, 2021 ). In the absence of estrogen, the dynamics of oral microbiota is changed ( Lucisano et al, 2021 ). Hormone levels were not included in our study, which certainly needs to be verified in the future studies.…”

Section: Discussionmentioning

confidence: 99%

Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient

et al. 2022

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The pathogenesis of oral lichen planus (OLP) remains unclear, and microbial dysbiosis has been proposed to play a role in the pathogenesis of OLP. Oral mucosal swabs from 77 OLP patients and 76 healthy subjects were collected. The bacterial community among the OLP lesion, the adjacent normal mucosal, and the oral mucosal surface in healthy people were analyzed by 16S sequencing. The factor of gender and age that may affect the flora distribution of OLP patients were explored. Results indicate no significant difference in microbiota between OLP and the adjacent group. Compared with the healthy group, Neisseria, Haemophilus, Fusobacterium, Porphyromonas, Rothia, Actinomyces, and Capnocytophaga significantly increased in the OLP group. Actinomyces increased in male OLP patients, and the other six bacteria increased in female OLP patients. In female OLP patients, Lautropia and Dialister were positively correlated with age. While in male OLP patients, Moraxella, Porphyromonas, and Fusobacterium were positively correlated with age. Functional enrichment analysis suggested that abnormal energy metabolism related to ATP synthases, abnormal transport and metabolism of glycans, amino acids, and vitamins, and disorders of the local immune microenvironment might exist in OLP lesion.

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Section: Discussionmentioning

confidence: 99%

Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient

et al. 2022

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“…Previous studies have investigated the relationships between female hormones (estradiol and progesterone) and bacterial amounts. For example, ovariectomy in mice showed that oral bacterial amounts increased as a result of estradiol deficiency (Lucisano et al, 2021), although this report did not focus on Prevotella species. In addition, Prevotella species have been found to change their characteristics according to estradiol levels (Könönen et al, 2022), of which Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens increased biofilm formation in the presence of estradiol (Fteita et al, 2015;Fteita et al, 2017).…”

Section: Discussionmentioning

confidence: 92%

Oral microbiome changes associated with the menstrual cycle in healthy young adult females

Yamazaki

Ogura

Minami

et al. 2023

Front. Cell. Infect. Microbiol.

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The relationship between the menstrual cycle and the oral microbiome has not been clarified. The purpose of this study was to assess potential changes in the oral microbiome of healthy young adults using 16S rRNA-based sequencing. Eleven females (aged 23–36 years) with stable menstrual cycles and without any oral problems were recruited. Saliva samples were collected before brushing every morning during the menstrual period. Based on basal body temperatures, menstrual cycles were divided into four phases, namely the menstrual, follicular, early luteal, and late luteal phases. Our results showed that the follicular phase had a significantly higher abundance ratio of the Streptococcus genus than the early and late luteal phases, whereas the abundance ratios of the Prevotella 7 and Prevotella 6 genera were significantly lower in the follicular phase than those in the early and late luteal phases and that in the early luteal phase, respectively. Alpha diversity by the Simpson index was significantly lower in the follicular phase than that in the early luteal phase, and beta diversity showed significant differences among the four phases. Using the relative abundance data and copy numbers of the 16S rRNA genes in the samples, the bacterial amounts in the four phases were compared, and we observed that the follicular phase had significantly lower amounts of the Prevotella 7 and Prevotella 6 genera than the menstrual and early luteal phase, respectively. These results indicate reciprocal changes with the Streptococcus genus and Prevotella genera, particularly in the follicular phase. In the present study, we showed that the oral microbiome profiles are affected by the menstrual cycles of healthy young adult females.

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“…The expression of estrogen receptors, speci cally β receptors, in both mucosal and serous acinar and ductal cells of minor salivary, parotid and submandibular glands has been described, suggesting that estrogens can directly regulate salivary gland function [30]. A recently published study demonstrated that low estrogen levels in uenced the microbial composition of the oral cavity in rats, increasing the amount of bacteria in the saliva and, therefore, contributing to the progression of periapical lesions [31]. Similarly, to the action of tamoxifen on mammary gland tissue (inhibition of estrogen receptors), this drug seems to exert the same effect on the salivary glands, inhibiting estrogen receptors and affecting the secretion and composition of saliva.…”

Section: Discussionmentioning

confidence: 99%

Association between tamoxifen and tooth loss in women with breast cancer

Sensever

Jardim

Ferrazzo

et al. 2022

Support Care Cancer

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Investigate the effect of tamoxifen on the occurrence of tooth loss (TL) in breast cancer (BC) survivors. MethodsA cross-sectional study was conducted with 140 BC survivors using tamoxifen therapy.Sociodemographic, medical and dental data were evaluated. TL was determined using the M component of the Decayed, Missing and Filled Teeth (DMFT) index. Logistic regression models were run to determine associations between the independent variables and outcome (TL). ResultsMean TL was 12.96 (SD 8.88). Only three participants had lost no teeth and 10.7% were completely edentulous. Participants who used tamoxifen for more than 1 year had a higher mean missing teeth (13.99 vs. 10.45; P = 0.030). After the adjustments, the occurrence of more than 12 missing teeth was 2.75-fold higher among women who used tamoxifen for more than 1 year (95% CI: 1.06-7.12). Moreover, age over 65 years, referral for treatment by the public healthcare system, less use of dental services, xerostomia and a lower occurrence of dental caries remained associated with the loss of more than 12 teeth. ConclusionLonger use of tamoxifen was associated with greater tooth loss in breast cancer survivors. Clinical relevance:Based on estimates of the increase in cases of breast cancer, the prolonged use of tamoxifen for the treatment of this disease can exert an impact on oral health through the occurrence of tooth loss. These ndings can contribute to the planning and implementation of oral health care and prevention strategies for such patients.

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Alteration of the oral microbiota may be a responsible factor, along with estrogen deficiency, by the development of larger periapical lesions

Cited by 10 publications

References 47 publications

Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient

Microbiome landscape of lesions and adjacent normal mucosal areas in oral lichen planus patient

Oral microbiome changes associated with the menstrual cycle in healthy young adult females

Association between tamoxifen and tooth loss in women with breast cancer

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