Alteration of the N6-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome
Lingxiao Zou,
Waixing Li,
Dabao Xu
et al.
Abstract:Objective
To explore the N6-methyladenosine (m6A) methylation abnormality of mRNAs and its potential roles in the mouse model of polycystic ovary syndrome (PCOS).
Methods
The mouse model of PCOS were induced by injecting dehydroepiandrosterone (DHEA), and confirmed by observing the morphological structures of ovarian follicles. Subsequently, m6A-tagged mRNAs were identified via m6A epitranscriptomic microarray and its potential functional pathways … Show more
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