Alteration of the Hypothalamus‐pituitary‐testis Axis in Oligozoospermic Men With Normal Gonadotropin Levels

Fujisawa, Masato; Kanzaki, Makoto; Hayashi, Akijumi; Tanaka, Hirokazu; Okada, Hiroshi; Arakawa, Soichi; Kamidono, Sadao

doi:10.1111/j.1442-2042.1995.tb00471.x

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Leydig and Sertoli cell functions are interrelated at several levels. Testosterone and estrogen exert negative feedback on both the hypothalamus and the pituitary, whilst inhibin selectively downregulates pituitary FSH [ 15 ]. There is a crosstalk between the thyroid function and HPG axis.…”

Section: Discussionmentioning

confidence: 99%

Study on the Interaction between Serum Thyrotropin and Semen Parameters in Men

et al. 2022

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The effect of thyroid function on semen parameters has been studied in pathological conditions in small studies. With this research work, we aimed to study thyroid hormone effects on semen parameters in 130 men who were evaluated for couple subfertility. Our study was cross-sectional. We noted semen volume, sperm concentration, total sperm count, testosterone levels and thyrotropin (TSH) levels. The analysis included ordinary least squares regression (OLS-R), quantile regression (QR) and segmented line regression (SR). Using OLS-R, a weak negative correlation was found between the logTSH levels and semen volume (r = −0.16, r2 = 0.03, p = 0.05). In Q-R, each incremental unit increase in logTSH decreased the mean semen volume between −0.78 ± 0.44 and −1.33 ± 0.34 mL (40–60th response quantile) and between −1.19 ± 0.71 and −0.61 ± 0.31 mL (70–90th response quantile) (p = 0.049). With SR, a biphasic relationship of sperm concentration with TSH was noted (positive turning to negative, peaking at TSH = 1.22 μIU/mL). Thus, a weak negative association between the TSH levels and semen volume was noted, showing a trough within the usual normal range for TSH. Moreover, a biphasic relationship between the sperm concentration and TSH was also noted, peaking at approximately mid-normal TSH levels. Based on our results, TSH explained slightly less than 3% of the variation in semen volume and 7% of the sperm concentration (thus, other factors, which were not studied here, have a more important effect on it).

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Section: Discussionmentioning

confidence: 99%

Study on the Interaction between Serum Thyrotropin and Semen Parameters in Men

et al. 2022

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“…21 Sperm motility and percent normal sperm morphology were lower in those with SCI than in healthy AB controls; basal levels of gonadotropins, LH, FSH, or both, were depressed in 28 subjects, of whom 9 had low levels of serum T; the exaggerated responses of gonadotropins to GnRH were only significant in those subjects with SCI who had basal levels of gonadotropins below the normal range when compared with normal controls. 21 Fujisawa et al 22 investigated the GnRH response to 52 men with SCI who had idiopathic oligozoospermia and normal basal levels of serum gonadotropins and T; of note, subjects who had lower sperm concentrations (o10 × 10 6 per ml) had significantly increased peak levels of gonadotropins than those with high sperm concentrations.…”

Section: Discussionmentioning

confidence: 99%